Sensitivity and Robustness for Bioanalysis
The proof is in the results
Sensitivity comparison of an Infliximab signature peptide. 20 uL of a 5 ng/mL Infliximab standard digest.
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The M3 MicroLC offers unparalleled sensitivity for biotherapeutic development. Micro flow rates increase the sensitivity of your small sample volume analyses by up to 10x, as compared to analytical flow LC-MS. This makes the M3 MicroLC system the only choice when high sensitivity LC-MS/MS is required.
Engineered for robustness, the M3 MicroLC ensures accurate and reproducible results for peptide quantitation.
Multiplexing for High Throughput
Routinely analyze hundreds of samples – day after day, year after year
Maintain high throughput with the trap-elute workflow. Sample workflows for loading 20 uL of sample.
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Designed for high throughput, the M3 MicroLC enables the use of trap-elute workflows. Sample is loaded onto at a high flow rate onto a trap column and then eluted for analysis at a micro flow rate. The result is up to 5x shorter run time than what can be achieved with direct inject micro flow.
Complete Microflow UHPLC Solution
Everything needed for bioanalysis
SCIEX offers a complete solution for your bioanalytical needs. Designed for ease of use with the SCIEX Turbo V™ source, we offer electrodes optimized for micro flow LC.
SCIEX offers MicroLC Columns in a wide range of particle sizes (2.7 µm - 5 µm), pore sizes (90Å - 300Å) and surface chemistries, including C18, C8, C4, CN, Phenyl, AQ, C18-superficially porous particles and Silane (SIL). Created specifically for fast peptide quantitation, we offer columns packed with HALO Peptide ES-C18.
Extracted Ion Chromatogram of 24 MRM transitions of tryptic peptides in a digested human plasma sample on a 0.3 x 150 mm HALO Peptide ES-C18 column. Flow rate was 10 µL/min; gradient 5- 35 % ACN in 10 min.