For research use only. Not for use in diagnostic procedures.
Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) is a powerful technology for probing and analyzing the spatial arrangement of molecules directly in thin tissue sections. Imaging mass spectrometry can be used to determine the distribution of thousands of unknown analytes in a single experiment, including proteins, peptides, lipids and metabolites.
Mass spectrometry imaging applications include endogenous biomolecule profiling, analyte characterization comparisons across samples times and treatment regiments, and analysis of dosed-drug metabolism and distribution. Our instrumentation, software, reagents, and workflows deliver the accuracy, precision, and reproducibility required for even the most challenging surface and tissue imaging experiments.
The sensitive TOF/TOF 5800 System can identify and characterize biomolecules in applications ranging from tissue mapping to proteomic discovery, with 10X the speed and sensitivity of any other MALDI TOF/TOF instrument and is the only system capable of acquiring MALDI MS/MS data from tissue samples. With its TOF/TOF Imaging Acquisition Software
, it provides a complete industry-leading solution for tissue imaging with micron-spatial resolution of larger biomolecules. The TOF/TOF 5800 achieves high-definition spatial resolution down to 1 µm on the same tissue sample, and high-sensitivity MS/MS spectra on a wide range of molecules including peptides, proteins and small molecules.
With the new Advion LESA® Clarity system, the SCIEX QTRAP 5500 and TripleTOF 5600+ Systems now complement the TOF/TOF 5800 System for mass spectrometry imaging for drugs, metabolites and other fragile analytes. Enabling the direct screening off any service without the need for sample preparation, LESA Clarity brings the benefits of nanoelectrospray/mass spectrometry to surface analysis and automates surface sampling for faster, more effective analysis.
Supporting all SCIEX MALDI TOF/TOF platforms, TissueView Software rapidly displays the spatial location and intensity of drugs, metabolites, lipids, peptides, and proteins in all tissue types and. It provides a seamless link between optical images, MS images, MS and MS/MS spectra, with software for enhanced processing and clearly displaying mass spectrometric imaging data for enhanced productivity.