To cope with the complexity of Biologics or Biotherapeutics, we continuously innovate to provide greater efficiencies for our partners.
Informatics tools that process data automatically, visualizations that confirm Amino Acid sequence and systems that provide LC separation for the most advanced mass spectrometry systems make it possible to rapidly and simply identify and quantify post-translational modifications (PTMs) as part of a routine peptide mapping analysis.
Disulfide bond mapping, glycopeptide profiling, and analysis of released glycans can all be performed on the same platform as peptide mapping, providing an efficient use of resources.
For characterization that better informs discovery and pipeline, tools for sequence variant analysis are indispensable to prevent inappropriate biologics being taken forward to production.
The tools used in comparability of biologics can also be applied to biosimilars, which need extensive physicochemical analysis.
Capillary electrophoresis technology plays a key role in the protein characterization process as it lends its strengths to the determination of protein purity, heterogeneity, and identity prior to their use in the clinic.