The SCIEX clinical diagnostic portfolio is For In Vitro Diagnostic Use. Rx Only. Product(s) not available in all countries. For information on availability, please contact your local sales representative or refer to https://sciex.com/diagnostics. All other products are For Research Use Only. Not for use in Diagnostic Procedures.
Trademarks and/or registered trademarks mentioned herein are the property of AB Sciex Pte. Ltd. or their respective owners in the United States and/or certain other countries.
© 2020 DH Tech. Dev. Pte. Ltd.
Post translational modifications can occur at every step of the manufacturing process. These modifications can have an effect on a molecule’s charge states and effect a molecule’s potency. Identifying these charge variants is required as a regulatory release assay. CZE (Capillary Zone Electrophoresis) makes charge variant analysis easier then ever before. In under 5 minutes of separation time, the CZE Rapid Charge Variant Analysis Kit can resolve a native state molecule’s charge variants with little-to-no method development and provide more resolution than icIEF or ion exchange chromatography.
SCIEX CZE Rapid Charge Variant Analysis Kit provides all of the necessary reagents to analyze a molecule’s charge variants based on its mobility. This widely applicable method provides a fast, powerful separation used to quantify charge variants with a buffer that serves as both a separation matrix and dynamic coating with a bare fused silica capillary. In addition, no sample dilution buffer is required; simply dilute the sample in water and you are ready for your separation.
SCIEX CZE Rapid Charge Variant Analysis Kit offers an out of the box solution widely applicable for charge heterogeneity analysis.
The SCIEX CZE Kit provides a fast and simple separation used to quantify charge variants with a buffer that serves as both a separation matrix and dynamic coating with a bare fused silica capillary. No sample buffer is required; simply dilute the sample in water and you are ready for your analysis.
The PA 800 Plus Pharmaceutical Analysis System is a robust analytical platform that provides characterization of product purity, charge heterogeneity and glycan analysis, to help you with the development and quality control of therapeutic proteins.
No need to inventory multiple cartridge types. One EZ-CE cartridge (part # A55625) for Purity, Rapid Charge Variant Analysis, and Fast Glycan Analysis
Technical Note: Native State Charge Variant Analysis of Commercialized Monoclonal Antibodies in Minutes
Flyer: CZE Rapid Charge Variant Analysis Kit
Webinar: Charge Heterogeneity Analysis of Biologics by High Resolution cIEF and High Throughput CZE Methods
mAb Charge Heterogeneity Analysis by CZE Part 3: A Test Method Fit for QC Testing
mAb Charge Heterogeneity Analysis by CZE Part 2: A case Study from Merck Sharp and Dohme
mAb Charge Heterogeneity Analysis by CZE Part 1: Results of an Intercompany Robustness Study
RUO-MKT-18-10365-A
For research use only. Not for use in diagnostic procedures.
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