The SCIEX clinical diagnostic portfolio is For In Vitro Diagnostic Use. Rx Only. Product(s) not available in all countries. For information on availability, please contact your local sales representative or refer to https://sciex.com/diagnostics. All other products are For Research Use Only. Not for use in Diagnostic Procedures.
Trademarks and/or registered trademarks mentioned herein are the property of AB Sciex Pte. Ltd. or their respective owners in the United States and/or certain other countries.
© 2020 DH Tech. Dev. Pte. Ltd.
Learn how Swiss Federal Institute of Technology (ETH Zurich), in collaboration with the Institute for Systems Biology in Seattle, WA, used next-generation QTRAP mass spectrometry technology to create assays for approximately 20,000 human proteins, generating the world’s first human Multiple Reaction Monitoring (MRM) Atlas.
SCIEX, a global leader in life science analytical technologies, today announced that scientists at the Swiss Federal Institute of Technology (ETH Zurich), in collaboration with the Institute for Systems Biology in Seattle, WA, used next-generation QTRAP mass spectrometry technology to create assays for approximately 20,000 human proteins, generating the world's first human Multiple Reaction Monitoring (MRM) Atlas, an online database that will be made publicly available. Scientists around the world can use this atlas to significantly advance biomarker research, protein-based drug development and fundamental biological and biomedical research. The MRMAtlas provides simple, validated assays expanding into never-before-seen areas of the proteome. This project involved ETH scientists led by Dr. Ruedi Aebersold, Ph.D., who will be featured in a November 9th live webcast of a technical presentation about the MRMAtlas.
The MRMAtlas is a new database that provides mass spectrometry-based assays to a large proportion of the human proteome, enabling researchers to minimize the tedious and time-consuming task of assay development. Many scientists see MRM assays as an improvement over current immunoassays, such as Western Blotting and ELISA, which use antibodies. Immunoassays can be very costly and time-consuming to develop and can have issues with specificity. The new database of MRM assays is similar to a large library of ready-to-go antibodies to specific proteins, but the difference is that hundreds of proteins and peptides can be detected and quantified in a simple mass spectrometry assay and without the issues of cross reactivity.
The development of the MRMAtlas was dependent on QTRAP technology, which uniquely combines in a single analysis the quantitative MRM capabilities of normal triple quadrupole systems, with advanced linear ion trap capabilities for protein identification and confirmation. This gives researchers a clearer picture of each assay and eliminates ambiguity, meeting the requirements of the scientists at ETH Zurich. The industry-leading sensitivity of the SCIEX QTRAP systems also means the scientists were able to develop assays to low abundant proteins in the proteome. Using synthetic peptides for the QTRAP technology to analyze, the scientists at ETH developed this comprehensive library of MRM assays with unprecedented speed of 100 peptides per hour.
Ruedi Aebersold, Ph.D., Professor, Institute of Biotechnology at the Swiss Federal Institute of Technology
"MRM assays are set to change the world of proteomics. The MRMAtlas is a tool for advancing protein analysis. This accomplishment by a dedicated group of scientists is an important milestone and will improve our understanding of the analysis of the human proteome. We could not have developed the MRMAtlas as quickly and productively without QTRAP technology."
Andy Boorn, Chief Operating Officer, SCIEX
"The adoption of SCIEX QTRAP systems to help create the MRMAtlas will unlock the real power of mass spectrometry for proteomics analysis. Scientists will now be able to analyze huge numbers of proteins in the human body all at the same time, which has significant ramifications for biomarker research and ultimately personalized medicine. The QTRAP systems are essentially the best triple quadrupoles available but with additional, unique capabilities. They continue to help deliver significant scientific results, such as this landmark MRMAtlas project."
Webcast on the MRMAtlas
The webcast with Dr. Ruedi Aebersold will be held on Tuesday, November 9 at 5pm CET/ 11am EST/ 8 am PST. Participation requires online pre-registration. Click here to register.
QTRAP technology overview
SCIEX mass spectrometry portfolio
SCIEX is a global leader in the development of life science analytical technologies that help answer complex scientific challenges. The company provides scientific instrumentation, software and services used to discover new drugs, advance medical science and protect the food supply and the environment. SCIEX technology solutions combine the highest performance with the highest reliability to enable our customers to fuel scientific discovery, deliver results with confidence and improve the quality of life. The company has a more than 20-year history of innovation and market leadership as the former Applied Biosystems/MDS Analytical Technologies joint venture. For more information about SCIEX, go to www.absciex.com. Follow SCIEX on Twitter @ABSCIEX and on Facebook.
Social Media Tags
MRMAtlas, SCIEX, mass spectrometry, proteomics, protein analysis, peptide, MRM, triple quadrupole, QTRAP
For Research Use Only. Not for use in diagnostic procedures. The trademarks mentioned herein are the property of AB Sciex Pte. Ltd. or their respective owners. AB SCIEXTM is being used under license.
A new password has been sent to your email.
You have added a user.
This serial number could not be found. Would you like to submit the case anyway?
Your password has been updated.
Your account is now created.
A verification link has been sent to your email.
A new password has been sent to your email.
Your insturment has been removed.
Your privacy settings are now updated.
Software has already been registered to another instrument. Please check your AID and try again.
If you want to change the License Key to another instrument, please submit a new case.
Software has already been registered to the instrument selected.
Please check your instrument's software by going to the Instruments page and selecting the instrument in your "My Instruments" section. Here you will see a Software tab where you can view your instrument's software information.
You can also go to the Registered Software page to view software associated with your instrument(s).
If you are not finding what you are looking for, please submit a new case.