For research use only. Not for use in diagnostic procedures.
Bioanalytical studies of oligonucleotide theapeutics require sensitive, specific and robust assays. Many ELISA-based oligonucleotide measurements do not accurately distinguish large metabolites from the full-length oligonucleotide of interest. ELISA and UV-based measurements have limited dynamic range which complicates quantitative analysis of oligonucleotides in complex matrices.
Continuing its history of enabling customers to achieve success in bioanalysis of all molecule types, SCIEX provides solutions for quantification of oligonucleotides, offering scientists the ability to develop methods that produce high selectivity in complex biological matrices. TripleTOF Systems contribute the unique capabilities of qualitatively verifying oligo sequences with increased dynamic range. The solutions also offers the ability to develop multiplexed assays without additional upfront method development time, which in turn allows bioanalytical.