by Kerstin Pohl | Apr 17, 2024 | Biopharma, Blogs, PA 800 system
Read time: 7 minutes Prime editing (PE) is a next-generation gene editing technology that utilizes a Cas9 protein fused to a prime editing guide ribonucleic acid (pegRNA) to achieve high CRISPR/Cas9 editing efficiency and precision. However, the length requirement of...
by Kerstin Pohl | Apr 16, 2024 | Biopharma, BioPhase 8800 system, Blogs
Read time: 6 minutes Certain next-gen vaccines and gene therapy applications rely on the usage of adeno-associated viruses (AAV) as a delivery vehicle. To ensure the safety and efficacy of viral vector drugs, multiple critical quality attributes (CQAs) need to be well...
by Gitte Barknowitz | Apr 4, 2024 | Agriculture, Blogs, Food / Beverage, Food and Beverage
Read time: 7 minutes Allergy policies for nut-free commercial flights and nut-free childcare settings are not a rare occurrence nowadays—the reason is a rise in food allergies. Nuts are the most potent allergenic foods in terms of the amount that is required to elicit...
by Roxana McCloskey | Mar 28, 2024 | Biopharma, Blogs, Intabio ZT system, ZenoTOF 7600 system
Read time: 5 minutes Monitoring product quality attributes (PQAs) throughout monoclonal antibody (mAb) development is vital to ensuring drug safety and efficacy. By adopting orthogonal analytical techniques and integrating new technologies that have the potential to...
by Kerstin Pohl | Mar 14, 2024 | Biopharma, BioPhase 8800 system, Blogs, ZenoTOF 7600 system
Read Time: 7 minutes Interviewee: Jane Luo (PhD), Senior Scientist, SCIEX Lipid nanoparticles (LNPs) are widely used vehicles for mRNA-based therapeutics and vaccines. However, ionizable lipids used in LNPs can be susceptible to N-oxide impurities that can cause...
by Pierre Negri | Mar 11, 2024 | Blogs, Forensic, SCIEX OS software, Toxicology, ZenoTOF 7600 system
Read time: 4 minutes LC-MS/MS is a powerful analytical tool in forensic toxicology testing that can support a variety of testing regimes such as screening, confirmation and quantitative workflows. More specifically, analysis of NPS using LC-MS/MS provides many...
by Pierre Negri | Mar 11, 2024 | Blogs, Clinical, Forensic, QTRAP / Triple Quad, Toxicology
The development of analytical methods for the detection and quantitation of drugs and metabolites in a range of biological matrices is a challenging process. Forensic toxicology labs need a reproducible and reliable methodology to ensure the robustness of the data and...
by Garrett Deletti | Mar 7, 2024 | Other, QTRAP / Triple Quad, Questions, SCIEX OS software
When using SciexOS software analytics application: If a filename was accidentally repeated for multiple sample analyses (i.e. copy and paste line items in the batch builder, then forgot to change filename for individual instances), is it possible to change the...
by Rahima Danishmand | Mar 7, 2024 | CE, QA/QC, Questions, SCIEX OS software
How do I set up my processing method to calculate the RRT of the main peak to 10kD in karat 32 software?
by Arielle Cocozza | Mar 7, 2024 | LC, Other, Questions, SCIEX OS software
I have a Exion LC AD fitted with the Exion LC AC PFAS kit – I’m looking into running another application on the instrument alongside PFAS analyses that uses 0.2% Formic Acid in H2O as one of the mobile phases. I can’t find any literature on whether...