ADME profiling is typically performed on candidates later in the development cycle but performing these screens earlier would provide significant benefits. However, significant gains in sample analysis throughput would be required as the number of compounds to be tested would likely increase by an order of magnitude. Acoustic Ejection Mass Spectrometry (AEMS) on the Echo® MS system is a very high throughput quantitative technique that is ideal for labs performing in vitro ADME. Here using a metabolic stability assay, a ~10x increase in sample throughput was demonstrated when using the Echo® MS system coupled with LeadScape Analyze software as compared to an LC-MS/MS approach.
Here, the use of very fast microflow LC gradients was explored for protein identification experiments, using gradients as short as five minutes. Combined with MS/MS acquisition rates as fast as 66 Hz on the TripleTOF® 6600 System, good protein identification results are achieved providing high sample throughput.
In this poster talk André Schreiber, Applications and Product Manager for Food and Environmental Markets at SCIEX guides you through a new method developed in conjunction with Association of
The software package, PeakView® 2.2, CloudConnect 1.2 beta and SWATH® 2.0.1 software. is needed to perform the OneOmics workflow and/or SWATH protein data processing and is Windows 7 and Windows 10, 64-bit compatible.
Link is provided and installations instructions are described
Digital PicoView® Source is a nano ion source from New Objectives that is Windows 10 compatible and can be used with many SCIEX mass spectrometers.
Many users find that they cannot activate their Analyst® 1.7 software license file on a Windows 10 operating system because the folder where the license file is installed does not show.
To resolve an error that prevents the SQL database from connecting with DiscoveryQuant™ software 3.0.2 in Windows 10, SQL user accounts with the password enabled must be used.
Windows 7 and 10 operating systems are compatible with Analyst® Administrator Console 3.0 software.
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