Native Mass Spectrometry

Observe non-covalent interactions with native mass spectrometry

Native mass spectrometry (or native mode analysis) has always been very interesting, but it has also become very useful. Analyzing non-covalent species is required for new and emerging classes of protein therapeutics, such as bispecific and multi-specific antibodies. It is also needed to identify size variants of conventional monoclonal antibodies (mAbs). SCIEX has answered the call for high-resolution, native mass spectrometry with our Turbo V™ Ion Source design and ion optics. SCIEX technology is ideally suited to efficient and gentle desolvation of non-covalent complexes, which enables aggregate analysis, stoichiometry determination and fragment-based drug design.

Witness higher level interactions for a higher level of understanding

Native mass spectrometry enables better development of both current and next generation biologic therapies. Native mass spectrometry provides accurate information on higher level structure, aggregate identity, non-covalent binding and stoichiometry of binding. SCIEX native mass spectrometry solutions enable scientists to achieve dalton-specific confirmations of both protein–protein and protein–ligand non-covalent interactions.