Take a deep dive into the characterization of charge variants on an ADC using icIEF-UV/MS AstraZeneca’s scientists saw an unexpected shift in their cIEF profiles when characterizing their ADC. What was causing this change in charge heterogeneity? Learn how they solved this puzzle in minutes and identified the cause of these shifts.

This webinar discusses the use of an integrated icIEF-UV/MS workflow to :

• Reduce charge heterogeneity analysis workflow from weeks to minutes.
• Elucidate critical post-translational modifications (PTMs), including glycosylation, deamidation, and payload modifications.
• Enable mass characterization of charge variants and payload modifications of intact ADCs.
• Monitor charged modifications on ADC payload in near real-time