SCIEX will present the latest LC-MS and CESI-MS solutions with the broadest range of ESI-MS flow rates to address analytical in a broad range of fields.
With the increased use of bio-therapeutics, there is a need for sensitive quantitation of antibodies in limited amounts of plasma. In our seminar, we will discuss the application of an on-line pre-concentration workflow for the quantitation of antibodies with increased sensitivity compared to conventional LC/MS. It has been demonstrated that microLC improves sensitivity in LC/MS based assays, and the addition of trap-elute allows for the analysis of larger sample volumes with microLC, while maintaining sample throughput. Other applications of microLC-MS, e.g. the analysis of vitamin D analogues, will also be shown.
Furthermore, we have developed a new front-end separation and ionization technology called CESI, which combines the high efficiency and ultra-low flow of capillary electrophoresis (CE) with an integrated electrospray ionization source. This optimization of electrospray ionization (ESI) into the nanoflow region has shown to greatly improve assay sensitivity and reduce ion suppression. Our improvements in assay sensitivity and reduction in ion suppression reveal new information that is critical to your research, whether you’re characterizing a biopharmaceutical, identifying the proteins that make up a specific proteome, analyzing post-transitional modifications, or studying a metabolomic fingerprint.