Join SCIEX at US HUPO 2026
Extraordinary discoveries await
SCIEX is heading to US HUPO 2026!
Stop by Booth #19 and dive into the future of proteomics with us. Connect with the SCIEX team and discover how advanced mass spectrometry and data-driven workflows are accelerating discoveries across translational research, biomarker development, and systems biology.
See what’s new, what’s next, and what’s possible with SCIEX.
We can’t wait to see you in St. Louis!
SCIEX sponsored lunch seminar
From discovery, quantitative validation, and deep characterization: Streamlining biological insights with the SCIEX ZenoTOF 8600 system
Monday, February 23, 12:30 - 13:30
Grand Ballroom AB (Hyatt Regency St. Louis at the Arch, 315 Chestnut Street, St. Louis, MO, 63102)
Join SCIEX on Monday, February 23, for lunch to learn about the latest advancements in proteomics using SCIEX technologies. This chapter of SCIEX high-resolution accurate mass systems introduces a whole new level of proteomic depth, sensitivity, and speed, made possible only by Zeno trap-enabled technology. Our lineup of leading proteomics experts will present recent scientific findings and discuss how the ZenoTOF 8600 system redefines the achievable boundaries of modern proteomics. By combining ultra‑high MS/MS sensitivity, quantitative precision, and next‑generation ion activation technologies, the ZenoTOF 8600 system delivers depth, robustness, and analytical flexibility required for today’s most demanding biological questions.
The ZenoTOF 8600 system: From single cell to diverse proteomics applications
Presented by Tim Heymann, Max Planck Institute of Biochemistry (Mann lab), Germany
Abstract: Mass spectrometry-based proteomics increasingly demands platforms combining quantitative robustness with discovery capabilities. Quadrupole time-of-flight instruments provide accurate mass information essential for identification, while triple-quadrupole systems have traditionally offered superior sensitivity for targeted quantitation. The ZenoTOF 8600 system, however, integrates front-end ion optics from SCIEX most sensitive triple-quadrupole platform with Zeno trap-enabled QTOF analysis, aiming to bridge this divide. Key architectural changes include an enlarged sampling orifice, DJet/QJet dual ion guides, contamination-filtering Mass Guard technology, and a new optical detection system that extends the linear dynamic range approximately 50-fold.
Here, we have characterized the proteomics performance of the ZenoTOF 8600 system across global proteomics, single-cell applications, and targeted quantitation to establish its analytical capabilities.
Chromatogram-based chemoproteomics with ZenoTOF 8600 system and Skyline
Presented by Lindsay Pino, Talus Bio, Seattle, WA
Abstract: Mass spectrometry proteomics is rapidly gaining traction as a core modality in drug discovery, supporting applications from chemoproteomic hit identification to target engagement, degrader selectivity profiling, and characterization of complex biologics. In parallel, mass spectrometry-based approaches are expanding access to therapeutically relevant protein classes that remain challenging for structure-based or purely computational methods, including intrinsically disordered and chromatin-associated proteins such as transcription factors.
Here, we highlight chemoproteomics workflows enabled by the SCIEX ZenoTOF 8600 system, focusing on how advances in Zeno trap-activated fragmentation, high MS/MS sensitivity, and fast acquisition speeds support confident, residue-level detection of covalent small-molecule binding events in complex biological samples. We discuss practical considerations for deploying these workflows in discovery-stage biopharma settings, including depth of coverage, quantitative robustness, and throughput, and outline how next-generation TOF performance can translate into actionable insights for early drug discovery while maintaining rigorous analytical standards.