Overcoming bioanalytical challenges and evaluating workflow strategies for GLP-1 therapeutic quantitation in biological matrices using HRMS

Shane Needham, PhD, Founder & CEO, Veloxity

Discover how the ZenoTOF 8600 system performs for quantitative GLP-1 bioanalysis compared to the SCIEX 6500+ system. Learn how enhanced selectivity can deliver strong sensitivity while accelerating method development for peptide workflows.

• Compare quantitative GLP-1 workflows on the ZenoTOF 8600 system and SCIEX 6500+ system
• Discover how enhanced selectivity supports highly sensitive peptide analysis
• Accelerate peptide screening with method development up to 4-5x faster

Immunocapture-LC/HRMS intact analysis for investigating PNU-ADC deglycosidation in vivo

Lin-Zhi Chen, PhD, Distinguished Research Fellow, Boehringer Ingelheim Pharmaceuticals

Ultrasensitive multiplexed bioanalysis of complex modalities using the SCIEX 7500+ system: A CRO perspective

Ryan Darling, Associate Director, Mass Spectrometry Bioanalysis, KCAS Bio

Learn how a leading CRO is using the SCIEX 7500+ system to support ultrasensitive, multiplexed bioanalysis of complex therapeutic modalities. Explore approaches for quantifying ADCs, APCs, and AOCs while achieving lower LLOQs and simplifying bioanalytical workflows.

• Quantify complex modalities, including ADCs, APCs, and AOCs, in a single workflow
• Enable multiplexed analysis of antibodies, payloads, and oligonucleotides
• Achieve lower LLOQs with enhanced sensitivity and simplified workflows

Quantification of GLP-1 peptides and oligonucleotides in biological matrices using QTOF HRMS

Lata Venkatarangan, Director, Bioanalytical, QPS

Discover how the ZenoTOF 8600 system enables sensitive quantitation of both GLP-1 peptides and oligonucleotides using MRMHR workflows. Learn how the platform delivers strong performance across diverse therapeutic modalities, supporting quantitative bioanalysis with a single high-resolution system.

• Explore MRMHR-based quantitation of GLP-1 peptides and oligonucleotides on a single platform
• Achieve sensitive quantitation at sub-ng/mL levels using the ZenoTOF 8600 system
• Learn how the system delivers strong sensitivity and linearity across multiple therapeutic modalities

Mass spectral characterization of therapeutic oligonucleotide metabolites

Tim Snow, Principal Scientist, QPS

Discover practical workflows for characterizing and profiling therapeutic oligonucleotide metabolites, including antisense and siRNA therapeutics. Learn how LC-HRAM/MS and specialized software can help streamline metabolite identification, data interpretation, and regulatory support.

• Gain insights into therapeutic oligonucleotide metabolite characterization.
• Accelerate metabolite identification and data processing with Molecule Profiler software.
• 1. Improve confidence in high-resolution MS/MS data interpretation.

Less is more: Leveraging acoustic ejection mass spectrometry (AEMS) to accelerate drug discovery endpoints

Neal Liddle, Principal Scientist, Iambic

Learn how acoustic ejection mass spectrometry (AEMS) enables rapid endpoint generation across a range of bioanalytical and physicochemical assays. Discover how these high-throughput workflows are helping accelerate decision-making, support medicinal chemistry, and speed the drug discovery process.

• See how AEMS helps accelerate the design-make-test cycle
• Generate actionable data rapidly across a range of drug discovery assays
• Streamline routine workflows with a robust and user-friendly platform

SCIEX OS software in practice: Customer voices, real results

Rafa Terán, General Manager, Smartbio Analytics

Hear directly from Rafa's experience implementing SCIEX OS software. Learn how digital workflows can improve productivity, strengthen compliance, and help future-proof laboratory operations.

Inside the SCIEX OS software journey: Customer questions & insights

Federico Pastori, LIMS Consultant, LabWare

Learn from Federico as he shares his experience with adopting SCIEX OS and managing the migration. He answers commonly asked questions about SCIEX OS and how his lab found the journey.

From single-cell to diverse proteomics applications

Tim Heymann, PhD, Mass Spectrometry Specialist, Max Planck Institute of Biochemistry (Mann Lab)

Discover how the ZenoTOF 8600 system supports proteomics workflows ranging from single-cell analysis to deep proteome profiling and ultra-high-throughput studies. Learn how ZT Scan DIA delivers improved performance over conventional Zeno SWATH DIA, enabling deeper coverage, robust quantification, and high-throughput analysis on a single platform.

• Quantify more than 4,000 protein groups from single cells and up to 10,000 from bulk samples
• Achieve robust proteomics at throughput levels of up to 500 samples per day
• Discover how ZT Scan DIA outperforms conventional Zeno SWATH DIA across multiple proteomics workflows

EAD provides new insights into human biology with deep glycome analysis

Bogdan Budnik, Director, Multi-omics Discovery Engine, Wyss Institute

Human glycosylation is remarkably complex, with subtle structural differences playing important roles in biology and disease. This presentation explores how EAD is advancing glycomics by enabling deeper characterization of glycan heterogeneity and providing richer structural insights into human glycosylation patterns.

• Characterize glycan heterogeneity with greater structural detail
• Leverage EAD to gain deeper insight into complex glycosylation patterns
• Advance glycomics research with richer and more informative data

The use of ZT Scan DIA to increase the coverage of novel conjugated lipids

Alex Dickens, PhD, Research Council of Finland Fellow, University of Turku

Enhanced MS/MS sensitivity with ZT Scan DIA on the ZenoTOF 8600 system is enabling deeper characterization of novel conjugated lipids and more confident analysis of complex biological samples. Discover approaches for generating high-quality spectral data to support lipid identification and quantification in challenging matrices.

• Increase MS/MS sensitivity for deeper characterization of novel conjugated lipids
• Generate high-quality spectra for more confident lipid identification and quantification
• Support robust analysis of complex biological matrices with enhanced sensitivity

Trust, but verify: Mass spectrometry for food authenticity, safety and human exposure

Dr. Awanwee Petchkongkaew, Associate Professor and Director, Center of Excellence in Global Food Security, Thammasat University

From food authenticity to human exposure assessment, mass spectrometry is helping generate the analytical evidence needed to support safer and more secure food systems. This presentation highlights applications spanning seafood and halal authentication, biogenic amine detection, and mycotoxin exposure monitoring through urinary biomarkers.

• Verify food authenticity and integrity using mass spectrometry-based approaches
• Assess food safety risks from contamination through to human exposure
• Generate the analytical evidence needed to support informed decisions and consumer trust

Evaluating the relative importance of polyfluoroalkyl substances in AFFF-impacted soils

Sara Jones, Graduate Researcher, Colorado School of Mines

PFAS contamination at AFFF-impacted sites extends beyond routinely monitored compounds. Learn how LC-HRMS workflows were used to characterize PFAS diversity across multiple contaminated sites, revealing important precursor compounds and providing deeper insight into environmental contamination profiles.

• Reveal PFAS compounds and precursors that may be missed by conventional approaches
• Improve characterization of AFFF-impacted sites with LC-HRMS workflows
• Explore strategies for addressing PFAS diversity beyond targeted analyte lists

Novus V55 system for routine pesticide screening

Guillaume Morin, Head of R&D, GIRPA

Evaluate the novus V55 system for high-throughput pesticide residue screening across diverse plant matrices using existing chromatographic conditions and MRM transitions. See how the system delivered performance comparable to the SCIEX 5500 system while increasing productivity, reducing energy consumption, and minimizing laboratory footprint.

• Comparable performance to the SCIEX 5500 system for routine pesticide screening
• Up to 3.3× higher productivity using existing MRM methods
• Up to 79% lower energy consumption per sample

Machine learning-guided identification and monitoring of halogenated compounds in drinking water

Tingting Zhao, Postdoctoral Researcher, University of Alberta

Machine learning and non-targeted LC-HRMS are expanding the ability to identify previously unrecognized halogenated compounds in drinking water. This presentation highlights a workflow for discovering, identifying, and monitoring halogenated contaminants, combining advanced data analysis with targeted quantification for environmental monitoring.

• Reveal previously unrecognized halogenated contaminants in drinking water
• Increase confidence in compound identification using LC-HRMS and MS/MS workflows
• Accelerate large-scale screening and monitoring with machine learning-driven tools

The future of mass spectrometry

Moderated by: Jamie Wighton, Senior Director, LCMS Research, SCIEX

Panelists include:

Rafa Terán, Smartbio Analytics

Tim Heymann, Mann Lab (Max Planck)

Neal Liddle, Iambic

Jose Castro-Perez, VP, SCIEX

Birgit Schilling, Buck Institute for Research on Aging

Shaping the future of bioanalysis and MetID

Moderated by: Todd Stawicki, Senior Manager, Global Pharma Discovery Market, SCIEX

Panelists include:

Shane Needham, Veloxity

Tim Snow, QPS

Ryan Darling, KCAS Bio

The future of biotherapeutic analysis with HRMS

Moderated by: Paula Orens, Senior Manager, Global Biopharma Discovery Market, SCIEX

Panelists include:

Lata Venkatarangan, QPS

Lin-Zhi Chen, Boehringer Ingelheim Pharmaceuticals

ZT Scan DIA: Rethinking omics workflows

Moderated by: Katherine Tran, Senior Manager, Global Proteomics Market, SCIEX

Panelists include:

Alex Dickens, University of Turku

Tim Heymann, Mann Lab

Kristina Jurcic, Bioinformatics Solutions Inc.

Steffen Heuckeroth, mzio

Paul Baker, SCIEX

Advances in food safety and PFAS analysis

Moderated by: Holly Lee, Staff Scientist, Global Food & Environmental Applications, SCIEX

Panelists include:

Georg Pfefferer, Phenomenex

Jianru Stahl-Zeng, SCIEX