SELEX is a process that selects DNA or RNA from a random library of sequences based on their affinity for a target molecule. These high affinity ligands, called aptamers, have great potential for use as drugs or diagnostic agents. SELEX selection typically requires 8-15 selection rounds. Learn how to drastically shorten this process with capillary electrophoresis!
Key Learning Points:
Shorten the SELEX process to 48 hours.
Minimize non-specific binders.
Maximize high-affinity aptamers.
Determine affinity constants.
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Michael Bowser Professor of Chemistry, University of Minnesota