New psychoactive drugs: advanced hair analysis for epidemiological studies
The changeable profile of synthetic drugs introduced into the black market makes any tentative study on their diffusion uncertain. Rapid and highly performing UHPLC-MS/MS methods for hair analysis investigate new drugs diffusion among selected populations of abusers and provide valuable information with limited costs.
Prof. Marco Vincenti
Regional AntiDoping Center
Masking strategies in sport doping: New challenges for the antidoping laboratories.
This talk outlines the progressive evolution of the doping masking strategies, up to the most recent and potential, future developments of this field. In parallel, the evolution of the corresponding unmasking strategies set up by the WADA-accredited anti-doping laboratories is also presented and discussed.
Dr. Francesco Botrè
Laboratorio Antidoping, Federazione Medico Sportiva Italiana, Rome, Italy, and
Department of Experimental Medicine, "Sapienza" University of Rome, Italy
Systematic toxicological analysis with high-resolution tandem mass spectrometry
In this presentation, we will provide an overview on the current status of HR-MS/MS. We will place special emphasis on available strategies for automated and unattended acquisition of MS/MS spectra. In this context, possibilities and limitations of SWATH® in comparison to data-dependent acquisition control will be discussed. Another important topic covered by this presentation will be performance of compound identification with tandem mass spectral library search. We will demonstrate that databases have evolved to reliable and robust identification tools.
Prof. Dr. Herbert Oberacher
Institute of Legal Medicine
Innsbruck Medical University