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ASMS is always an exciting time of year for us at SCIEX. It gives us an opportunity to showcase many of the new developments coming out of research and development. This year in Atlanta, we were thrilled to introduce to you the exciting new SCIEX TripleTOF® 6600+ system, the latest innovation from SCIEX incorporating high resolution QTOF technology with easy to use OptiFlow microflow and nanoflow ionization sources, and the next leap in DIA- Scanning SWATH® acquisition.
Post-ASMS we had the opportunity to sit down with Jide Okandije, Product Manager for Accurate Mass technologies, to discuss how the TripleTOF® 6600+ system came about.
How did the concept of the TripleTOF 6600+ system come about?
The TripleTOF 6600+ system has been the flagship of our high performing accurate mass product line since its launch. Throughout its lifetime, we have collaborated closely with many customers to understand the highs and lows of using the 6600 to answer their scientific questions. From these conversations, we identified three main areas to focus on for the TripleTOF 6600+ system:
Read more about TripleTOF 6600+ system.
What technologies address the need for easy-to-low flow applications?
Through multiple conversations, it was apparent that the current solutions for enabling low applications were a challenge to operate efficiently. Customers indicated that NanoSpray III source and the Digital PicoView source required expertise in order to be successful. The objective behind the OptiFlow source was to bring low flow to all users and make it possible to go from an idle state to collection nanoflow or microflow data in minutes.
Early in the development process, we engaged our customers as part of the Early Customer Evaluation (ECE) program. They received prototype sources in their labs for a period of 6-12 months. With support from our service and application teams, the new source was installed on their instruments. Throughout the evaluation period there were regular touchpoints to review results, capture feedback and answer any questions that our collaborators had.
"The customers were open-minded and great. It was really good to work with the customers because they were really enthusiastic. They were as excited as we were to test the new product. I couldn’t be happier with the quality of feedback that we received, and it really helped to confirm that we were building the right product."
For more information, please visit OptiFlow technology.
What is Scanning SWATH® Acquisition?
SWATH Acquisition is a data independent technology that was introduced in 2012. It allows for the comprehensive detection and quantitation of every detectable compound in a sample. One of the challenges with SWATH Acquisition is that you need multiple methods to create a comprehensive view of the sample. Scanning SWATH Acquisition is one method to deliver all the required information. Scanning SWATH Acquisition allows users to go faster (compatible with high speed separations), while digging deep into a sample to get comprehensive quantitative results.
The research department has worked closely with external collaborators to refine the tools and workflows. It was our pleasure to have one of our collaborators present the results of their work at the ASMS user meeting. If you weren’t present at ASMS, register here to access the SCIEX Online Summit 2019, view talks from industry experts showcasing the newest advances in MS and CE technology, workflows and research.
Scanning SWATH Acquisition: Proteomics Done Fast – and What To Do With It - Christoph Messner, Postdoctoral Research Fellow, The Francis Crick Institute, United Kingdom
In the meanwhile, if you are interested in learning more about Scanning SWATH, you can refer to these presentations
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