CESI 8000 High Performance Separation-ESI Module with Table

CESI 8000 High Performance Separation-ESI Module

CESI 8000 High Performance Separation-ESI Module Sprayer

CESI 8000 Cartridge

CESI 8000 Head

이전 그림 다음 그림

CESI 8000 Plus 고효율 분리-ESI 모듈

연구 목적으로만 사용할 수 있습니다. 진단 절차에는 사용할 수 없습니다.

질량 분석기에 완벽한 액세서리

CESI: 모세관 전기영동(CE)과 Electrospray 이온화(ESI)가 동일한 장치 내에서 하나의 프로세스로 통합되었습니다.

결과:

향상된 감도와 감소된 이온 억제
1 µL 출발 물질에서도 확장된 정보
극성 분석물과 전하 분석물을 고분해능으로 분리
프로테오폼(Proteoform), 단백질 복합체 및 중요 PTM의 심도 깊은 특성 분석

다음 분야를 분석할 수 있습니다.

웨비나, 동영상, 브로셔, 기술 자료 및 설명서에 대해서는 아래 리소스 섹션을 참조하십시오.

CESI-MS가 어떻게 지원하는지 궁금하시면 지금 분석할 시료를 요청하십시오.

상태: 구매 가능

CESI 8000 Plus ESI-MS 시스템

새로운 기능

소량의 귀중한 시료에서 이전에 검출하지 못했던 특성을 과거 어느 때보다 빠른 속도로 발견해내는 혁신적인 ESI-MS 방식을 경험해 보십시오. CESI 8000 Plus를 독립 실행형 모세관 전기영동 장비로 사용하든 또는 질량 분석기와 함께 사용하든지에 관계없이 기술이 아닌 과학에 집중할 수 있습니다. 지금까지 시료를 얻기 위해 열심히 노력하셨습니다. 소중한 재료를 최대한 활용하고 이전에는 확인하지 못했던 숨겨진 정보를 찾아보십시오.

다중 이온화 사이트가 있는 프로테오폼 및 펩타이드 PTM
온라인 MS 검출을 통한 인택트(Intact) mAb 전하 변이
기본 조건에서 기본 단백질 구조 및 상호 작용
기존 기술로 분해할 수 없는 동위원소 대사산물 및 글리칸

고분해능 바이오치료제 분리를 위한 궁극적인 도구

다운로드 및 리소스

RUO-MKT-18-5206-E

CESI 8000_3col1

가능성 뛰어넘기

CESI 8000 Plus 고성능 시스템은 빠르고 효율적이며 고유한 분리 선택성을 향상된 감도와 함께 제공하는 동시에 적용 범위를 확장시킵니다.

인택트 프로테오폼(Proteform)

온라인 MS 검출을 통한 인택트 mAbs와 프로테오폼(Proteform)의 신뢰성이 높은 고감도 분리로, 사전 분리 및 재주입이 필요 없습니다.

자세히 읽기

동위원소 화합물

현재의 분석법으로 제대로 해결되지 않은 동위원소 화합물 분석을 간소화합니다.

자세히 읽기

기본 조건

기본 조건에서 단백질과 펩타이드의 분자 상호 작용 및 구조를 연구합니다.

자세히 읽기

CESI 8000_3col2

더욱 확대된 적용 범위

적용 범위가 확대되어 이전보다 더 많은 정보를 확인할 수 있습니다.

적용 범위 확대

LC 분석법으로는 불가능했던 친수성 전하 및 극성 화합물을 확인하고, 대사체 및 복합당질 분석의 감도를 높입니다.

자세히 읽기

새로운 PTM 확인

다중 이온화 사이트 및 당화 사이트와 같은 프로테오폼(Proteform)과 펩타이드 PTM을 높은 신뢰도로 정량화하고 특성 분석합니다.

자세히 읽기

이성체 분리

기존 LC-MS 분석법으로는 확인할 수 없었던 이성체를 확인할 수 있습니다.

자세히 읽기

Resources

Title	Date
Endogenous nucleotides from low numbers of mammalian cells	06/08/2020
Identification of multiple phosphorylation sites	05/18/2020
CESI 8000 Plus High Performance Separation-Site Planning Guide	04/24/2020
CESI 8000 Plus High Performance Separation-ESI Module User Manual	04/14/2020
No pressure HPLC	04/13/2020
Charge Variant Analysis by CESI-MS	04/07/2020
Identifying and Quantifying Aspartate and Iso-Aspartate Isomers	04/06/2020
CESI 8000 High Performance Separation - ESI Module	02/15/2020
CE Training Overview 2020	01/29/2020
CE Kit Brochure	01/22/2020
Quick Guide CE Instrument Maintenance	01/14/2020
Preparation Scale-Up Of Complex BiologicakSamples For Deep N-Glycomic Analysis By CE-LIF and CESI-MS	12/11/2019
Charge Heterogeneity Analysis in as little as 5 Minutes	11/04/2019
SCIEX Capillary Electrophoresis Consumables Guide	09/27/2019
Comprehensive Capillary Electrophoresis Training Course	07/26/2019
Better Insights into Charge Variants of Therapeutic IgGs	06/21/2019
Charge Heterogeneity Analysis of Intact Infliximab Using CESI-MS and Neutral OptiMS Cartridge	05/31/2019
Windows10 Announcement	03/20/2019
CESI 8000 Plus High Performance Separation-ESI Module Software Validation Summary	03/20/2019
CESI 8000 Plus High Performance Separation-ESI Module System Administration Guide	03/18/2019
OptiMS Silica Surface Cartridge Quick Start Guide	03/18/2019
Neutral OptiMS Cartridge Quick Start Guide	01/15/2019
Environmental Compendium Volume 3	12/10/2018
CESI-MS/MS: Quantitation of Highly Polar Pesticides	12/07/2018
Charge Variant Assessment of Nanobodies at the Intact Level by CESI-MS	10/24/2018
Resolving volume-restricted metabolomics using capillary electrophoresis-mass spectrometry	10/17/2018
A New-Method for the Determination of Acid Residues in Plant Matrices Using CESI-MS	03/14/2018
Innovations in Glycan Analysis on the PA 800 Plus, LC-MS and CESI-MS	03/10/2018
Intact Casein-A Model System for the Separation of Intact Phosphorylated Proteins by CESI-MS	01/25/2018
Improving the Detection Limits for Highly Basic Neuropeptides Using CESI-MS	01/10/2018
Ultra-sensitive Host Cell Protein Dection using CESI-MS with SWATH Acquisition	12/10/2017
Neutral OptiMS Cartridge Instruction Guide	08/31/2017
Expanding phosphorylation and post translational site mapping in proteomics using CESI-MS	08/24/2017
Detecting Challenging Post Translational Modifications (PTMs) using CESI-MS	08/20/2017
Solutions for Biotherapeutic Characterization	08/01/2017
Von Einzelmethoden zur Multimethode für polare Pestizide: Ist CESI-MS die Lösung	05/24/2017
Are Pork Extracts Present in My Gummy Bears? Gelatin Speciation by LC-MS/MS-poster	04/26/2017
CESI 8000 Plus paired with the TripleTOF 6600 for the analysis of Protein Therapeutics	02/28/2017
Improving Identification and Quantification of Polar Herbicides by CESI-MS	01/03/2017
Structural Characterization of Antibody Drug Conjugates (ADCs) By a Combination of Intact, Middle-up and Bottom-up Approaches Using CESI-MS	12/20/2016
Quantitation of Nucleotides and Nucleosides without derivatization using CESI-MS	12/15/2016
Unified workflow for monoclonal antibody charge heterogeneity	12/12/2016
Improved CESI-MS Glycopeptide Analysis using a Dopant Enriched Nitrogen Gas	12/09/2016
CESI-MS comparison of tryptic diges an assessment of bio similarity	11/28/2016
Intact Proteoform Characterization using CESI-MS	11/18/2016
CESI 8000 Plus OptiMS Adapter Kits	11/10/2016
Analysis of Intact MUPs (Major Urinary Proteins) from Mice by CESI-MS	11/09/2016
CESI-MS for Multilevel Characterization of Protein Therapeutics	10/12/2016
Highly Efficient and Sensitive Anionic Metabolic Profiling by Mass Spectrometry	09/12/2016
Solutions to Advance your Metabolomics Research	08/17/2016
Analysis of Disease-Induced Protein Mods Using CESI-MS	08/12/2016
Separations Part Number Catalog	08/01/2016
Method for CESI-MS Separation for Waters MS	08/01/2016
Waters Adapter Installation Guide	08/01/2016
Bruker Installation Guide	08/01/2016
CESI 8000 Plus High Performance Separations - OptiMS Adapter kit	07/12/2016
CESI-MS Separation Method for Bruker MS	07/08/2016
Glycomics and Glycoproteomics by CESI-MS for Biomarker Discovery and Biopharmaceutical Characterization	06/15/2016
UHPLC-ESI-QTOF-MS/MS based Lipidomics by Data-independent Acquisition	05/11/2016
Studying Kinetics of Chromatin Assembly with SWATH MS	05/11/2016
The Lipidyzer- a new platform for quantitative Lipidomics	05/11/2016
CESI-MS a technique for the characterization and analysis of both intact and digested biopharmaceuticals	05/11/2016
CESI 8000 Plus for CESI-MS Ease of Use	05/01/2016
Innovation for Biotherapeutic Comparability with BioPharmaView Software Solution Guide	05/01/2016
Capillary Electrophoresis and CESI-MS for Characterization of BioSimilars: rhuEPO	04/13/2016
OptiMS Adapter Kit Data Sheet	04/10/2016
Antibody-Drug Conjugate Structural Characterization – Part 1: Analysis of Conjugation Site DAR	03/16/2016
OptiMS Thermo MS Adapter Installation Guide	03/01/2016
Multilevel Characterization of Biologics with a Single Method	02/17/2016
Multilevel Characterization of Biologics with a Single Method-Jpn	02/17/2016
High resolution approach to the detection of insulin degradation products	02/16/2016
A new approach to the analysis ofanionicmetabolites by CESI-MS with negative ion electrospray ionization	02/16/2016
Host cell protein detection using CESI-MS with SWATH	02/09/2016
nanoVial brochure	01/15/2016
Conditioning Method Neutral Cartridge CESI 8000 Plus	01/15/2016
Peptide Separations Method Neutral Cartridge CESI 8000 Plus	01/15/2016
Protein Separations Method Neutral Cartridge CESI 8000 Plus	01/15/2016
General Separations Methods Other Than Peptides and Proteins Neutral Cartridge CESI 8000 Plus	01/15/2016
Unification of Charge Heterogeneity, Purity, and Molecular Weight Analyses of mAbs into a Single Analysis	12/05/2015
Separations Product Overview	12/01/2015
Neutral OptiMS Capillary Data Sheet	12/01/2015
CESI How to (short) for E-book	12/01/2015
Increasing Throughput with Multi-Segment-Injection-MSI-CESI-MS	10/01/2015
Analysis of Anionic Metabolites by CESI-MS	10/01/2015
Compact Quantitative Proteomics Workflow Combining SILAC Labeling, Chromatographic pre-fractionation and CESI-MS with Neutral Capillary Surface	10/01/2015
Ionization efficiency, Ion Suppression and Detection Sensitivity of CESI-MS	10/01/2015
New High Resolution approach to the Detection of Insulin Degradation products	10/01/2015
New Approach to the Analysis of Anionic Metabolites by CESI-MS with Negative ion Electrospray Ionization	10/01/2015
Metabolomics: New technology needed for depper understanding of Biological functions in sample-limited cases	10/01/2015
Chiral Analysis of Methamphetamine and it’s Metabolite, Amphetamine in Urine by CESI-MS	09/10/2015
ExionLC AC Series Extended Specifications	09/01/2015
Sensitive Glycoform Profiling of b-Interferon-1a (Avonex) and recombinant human Erythropoietin by CESI-TOF-MS	09/01/2015
Separation and Analysis of Intact Prostate Specific Antigen (PSA) and its Proteoforms by CESI-MS Under Native and Denaturing Conditions.	09/01/2015
A covalent, cationic polymer coating method for the CESI-MS analysis of intact proteins and polypeptides	08/31/2015
Comprehensive Analysis of Recombinant Human Erythropoietin Glycoforms by Capillary Electrophoresis and Nanoflow Liquid Chromatography Coupled with Intact/Middle-Down Mass Spectrometry	08/30/2015
Characterization of Phospho- and Glycopeptides by CESI-MS: A Powerful Technique for Increasing Sensitivity	07/01/2015
Ultra-sensitive Host Cell Protein Detection using CESI-MS with SWATH Acquisition	06/01/2015
Breakthrough Applications to Expand and Speed Biopharmaceutical Characterization	06/01/2015
Characterization of Intact Prostate Specific Antigen (PSA) and Its proteoforms by CESI-MS under Native and Denaturing Conditions	06/01/2015
Comprehensive characterization of three IgG forms using CESI-MS	06/01/2015
In-line Separation by Capillary Electrophoresis Prior to top-down Mass Spectrometric Analysis enables Sensitive Characterization of Proteoforms	06/01/2015
The Application of Capillary Electrospray Ionization with Negative Ion Electrospray Ionization for the Analysis of Plant Metabolites	06/01/2015
The Effect of Ultra-low Flow on the Ionization of Biotherapeutics	06/01/2015
The Use of Capillary Electrophoresis Coupled to Mass Spectrometry (CESI-MS) for Quantitation of Nucleotides and Nucleosides	06/01/2015
Coffee at the Conference #1: Meeting Rawi Ramautar	06/01/2015
P213W Ultralow ESI-MS Flow Rates Make a Difference in The Analysis of Biotherapeutics	01/28/2015
P223W Evaluating the Addition of Supercharging Reagents During CESIMS for Identification and Characterization of Biopharmaceuticals	01/28/2015
Application of CESI-MS on SILAC-based Quantitative Proteomics	09/30/2014
Complete Primary Structure and Biosimilarity Assessment of Monoclonal Antibodies in a Single Analysis from a Single Enzyme Using CESI-Tandem Mass Spectrometry	09/30/2014
Introduction to CESI-MS Meeting	09/30/2014
Monoclonal antibodies complete primary structure and biosimilarity assessment in a single analysis using CESI–MS-MS	09/30/2014
Qualitative and Quantitative Analysis of Post-translational Modifications Using CESI-MS	06/23/2014
Comprehensive Analysis of Recombinant Human Erythropoietin Glycoforms by Capillary Electrophoresis and Nanoflow Liquid Chromatography Coupled with Middle-down Mass Spectrometry	06/18/2014
Monoclonal antibodies primary structure and biosimilarityassessment in a single analysis using transient isotachophoresissheathlesscapillary electrophoresis-tandem mass spectrometry	06/15/2014
Evaluating the Addition of Supercharging Reagents During CESI-MS for Identification and Characterization of Biopharmaceuticals	06/01/2014
Comprehensive Characterization of Trastuzumab using a Single-Shot Peptide Mapping Approach with CESI-MS	04/14/2014
CESI-MS Analysis of Biofluids of Basic Drugs and Metabolites	04/14/2014
Rapid Characterization of Biologics with CESI-QExactive	04/07/2014
Efficient and Sensitive Characterization of Intact Proteins of Pharmaceutical Interest by CESI-MS	09/01/2011
An Introduction to CESI-MS	06/05/2011
CESI-MS of Intact Proteins	06/01/2011
Analysis of Fentanyl and It's Metabolite, Norfentanyl by CESI-MS (11-08008-P)	04/07/2008
Unleashing the Power of Your Mass Spectrometer Using Ultra Low Flow CESI	06/01/2005
Using CESI to Improve LOD & LOQ of Pharmaceuticals and Their Metabloites	06/01/2005
New Horizons for Metabolic Profiling of Urine
High Resolution Intact Glycoprotein Analysis by CESI-MS (11-0809-P)
Sheathless Capillary Electrophoresis - Mass Spectrometry (P-14618)
Analyzing Intact Proteins and Protein Complexes with CESI-MS
CE-ESI-MS MS as a tool in Protein Glycosylation Analysis
CE - Separation of Multiphosphorylated H1b
Generate High Resolution Separations of Intact Peptides for Online MS Analysis (CESI)
Generate High Resolution Separations of Intact Peptides for Online MS Analysis
Monoclonal antibodies complete primary structure and biosimilarity assessment in a single analysis using CESI-MS-MS
Multilevel Characterization of Biotherapeutics using CESI-MS: from Intact Protein to Peptide Mapping Approach
Polar Pesticide Analysis by CESI-MS
Probing a new volume regime in metabolomics by CESI
Therapeutic antibodies and related products design manufacturing and controls
Introducing the CESI 8000 High Performance Separation-ESI Module
Overcoming the Challenges of Quantifying Highly Polar Amines
NGB webinar-new protein modality

CESI 8000_3col3

보다 동적이고 효율적인 프로세스

CESI-MS는 10nL/min 미만의 초저유량을 갖는 보다 견고한 시스템을 질량 분석기에서 사용할 수 있게 하므로, 이온 효율성이 전반적으로 향상됩니다.

미량 시료 소비

시료 양은 제한된 경우가 많습니다. CESI-MS의 시료 소모량은 nL 기준이므로 대부분의 물질을 직교성 기법로 분석할 수 있습니다.

자세히 읽기

워크플로우 간소화

단백질 치료제의 다단계 특성 분석에 동일한 분석법 및 시약을 사용합니다. 설정을 변경하지 않고 양이온 모드 또는 음이온 모드로 전환할 수 있습니다.

자세히 읽기

더 이상의 좌절은 없다

개방형 튜브 기술은 나노 기술에서 흔히 느끼는 좌절감을 없애줍니다. 데드 볼륨을 최소화하거나 시료 이월 및 막힘을 더 이상 처리할 필요가 없습니다.

자세히 읽기

CESI 8000_4col

핵심 기능
치수	29.2 in (74.2 cm) H x 25 in (63.5 cm) W x 28.4 in (72.1 cm) D
휴대용 랩 벤치	36 in x 30 in (91.4 cm x 76.2 cm) 높이는 69~112cm 범위에서 조절 가능
무게(포장 상자 제외)	188 lbs (85.3 kg)
전기 요구 사항	전압: 100~240V, 50/60Hz
시료 트레이	48 CESI 바이알/0.3mL 마이크로 바이알 2개
버퍼 트레이	36 CESI 바이알 2개
압력 공급 범위	-5 to +100 PSI
필요 시료 용량	NanoVias 사용 시 5μl