In this experiment, SCIEX Triple QuadTM4500 LC-MS/MS System was used to establish a rapid method for the determination of 11 kinds of lipophilic marine toxins, which provided a simple and fast solution for the detection of lipophilic marine toxins in shellfish. This method completely covers the requirements for the detection of liposoluble shellfish toxins in the national Manual of risk detection of food pollutants and harmful factors issued by the National Food Safety Risk Assessment Center. It has the advantages of simplicity, rapidity, high sensitivity and accuracy, and provides a simple and rapid solution for shellfish quality monitoring and food safety risk assessment