Overview
Confidently complete your metabolite identification studies through your development process with dependable instruments run on intuitive, compliant-ready software.
Our LC-MS systems offer fit-for-purpose sensitive and robust performance.
Workflow
Small molecule metabolites
Imagine the advantage of unambiguous metabolite identification using liquid chromatography-mass spectrometry (LC-MS) reducing the need for additional safety testing during drug discovery. Quickly and easily generate the information you need using routine assays that are robust and efficient, enabling confident decision-making while also saving time and money.
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More confident identification of the site of metabolism
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Fit-for-purpose systems
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Save time and money during drug discovery
Figure 1: An example analyte that EAD enabled the confident identification of glucuronide conjugation by using diagnostic fragment ions.
Small molecule metabolites
Solution
- More established routine Met ID assays
- Robust sensitive analysis
ExionLC AE system
X500R QTOF system
SCIEX OS software
Service
Small molecule metabolites
Solution
- More challenging Met ID assays requiring additional analytical power
ExionLC AE system
ZenoTOF 7600 system
SCIEX OS software
Service
Featured resources
See how complementary MS/MS spectra provided by electron activated dissociation (EAD) fragmentation enabled the identification of phase 1 metabolites to support drug metabolism studies.
Read about a streamlined method for the characterization and identification of conjugated structures during drug metabolism studies.
Workflow
Oligonucleotide Met ID/biotransformation
Complete metabolite assignments from biotransformation of siRNA, antisense and other oligonucleotides using reliable and trustworthy high-resolution mass spectrometry solutions that ensure fragmentation optimization. Identify oligonucleotide-derived metabolites with confidence, despite large isobaric overlaps and high structural similarities. Use custom software modifications that meet your specific analytical needs.
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Confidently identify and assign metabolites with high-resolution mass spectrometry data
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Distinguish structurally similar oligonucleotide metabolites with fragmentation optimization
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Meet your specific analysis needs using custom software modifications
Oligonucleotide Met ID/biotransformation
Solution
- Detection and identification of relevant oligonucleotide biotransformations
ExionLC AE system
ZenoTOF 7600 system
Molecule Profiler software
Service
Oligonucleotide Met ID/biotransformation
Solution
ExionLC AE system
X500B QTOF system
Molecule Profiler software
Service
All resources
See an approach to rapidly identify top metabolites in a routine manner
See how complementary MS/MS spectra provided by electron activated dissociation (EAD) fragmentation enabled the identification of phase 1 metabolites to support drug metabolism studies.
Read about a streamlined method for the characterization and identification of conjugated structures during drug metabolism studies.
Read about rapid characterization and identification of therapeutic peptide catabolites from rat liver s9 fractions using the ZenoTOF 7600 system
Learn about a method developed for the identification, relative quantitation and structural confirmation of oligonucleotide metabolites in plasma, with sequence coverage at levels down to 1%.
Read about the identification, relative quantitation and structural confirmation of nine oligonucleotide metabolites spiked in a rat plasma extract.
Associated applications
ADME-Tox and DMPK
Advance the development of your next therapeutic drug with easy-to-operate, integrated analytical systems that can provide new insights into ADME-Tox and DMPK. Rapidly and comprehensively characterize drug candidates with robust and sensitive solutions for identification, monitoring and quantitation.
Biomarker quantitation
Explore the potential of trusted LC-MS/MS solutions designed to simplify and accelerate biomarker quantitation. Bring drug candidates through the development pipeline more efficiently and confidently with accurate results obtained using innovative hardware and software, lab-tested methods and expert support.
High-throughput mass spectrometry
Screen thousands of candidates for desirable drug properties and process data with confidence faster than ever before. Get the information you need to make go/no-go decisions as quickly as possible in the drug discovery phase of your work.
Targeted protein degraders and PROTACs
Easily advance your targeted protein degraders and proteolysis targeting chimeras (PROTACs) with reliable and sensitive analytical data. Give your team the confidence to develop synthetic therapeutics with the support of the SCIEX technical team.