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Designed for seamless integration with SCIEX mass spectrometers, ExionLC analytical HPLC and UHPLC systems provide the speed, sensitivity, resolution, and reliability that you need for routine or complex LC-MS analysis.
An affordable system that can handle a wide range of applications. With both HPLC and UHPLC capabilities the ExionLC AC is a reliable robust solution for routine analysis.
ExionLC AD (shown below):
The system combines near zero carryover, full UHPLC capabilities to provide world-class performance under the most demanding analytical conditions.
0.0001 to 10.0 mL/min
9,500 to 18,850 PSI
Innovative flow through design, ability to choose multiple rinse solutions
Up to 768 samples with 384 well MTP (expandable to 12 plates/trays with rack changer option)
Choice of compact two-column oven, or six-column.
Multiplate autosampler (AD only), rack changer, and optical detectors
|Key Features||ExionLC AD||ExionLC AC|
|UHPLC/ HPLC Performance||18,500 PSI (1300 bar)||9,500 PSI (660 bar)|
|Ultralow Carryover||0.0015% maximum||< 0.005%|
|Cooled Autosampler||Direct cooling, 4 to 40°C
(under specified conditions)
|Direct cooling, 4 to 40°C
(under specified conditions)
|Temperature Controlled Column Oven||Room Temp. +5° C to 150°C, 2 column capacity
(AC column oven also compatible)
|Room Temp. -10° C to 85°C, 6 column capacity
(AD column oven also compatible)
|Wide pH Range||1-9 (standard)
Modular components allow you to update your system to keep pace with changing requirements. Add a column switching valve, two additional pumps and do on-line SPE. Add a PAL autosampler for automatic sample dilution or on-line microSPE.
Allows you to select between two solvents per channel from up to 3 different pumps.
Up to 12 additional cooled sample trays or vial racks to the AC or AD system.
Expands capacity with 324 x 1.5 mL vials, or 6 microtiter plates in 96 or 384 formats.
Increase productivity by adding a PAL RSI or PAL RTC Autosampler.
Time programmable wavelength switching allows detection sensitivity and selectivity.
|Fast Screening Method for 86 Forensic Analytes in Human Urine QTRAP 4500||05/10/2107|
|Elucidation and tracking of charge variants in antibodies: combining ease-of-use with a gain in information||09/25/2020|
|Rapid, sensitive analysis of sphingolipid variant profiles with simplified sample extraction||09/25/2020|
|Detección de Impurezas de Anticuerpos Intactos en SCIEX X500B||08/28/2020|
|Forensic Authentication of Hemp-Derived Products Using Mass Spectrometry||08/17/2020|
|Multi-panel detection of drugs and drug metabolites in hair samples using a comprehensive extraction method||08/12/2020|
|Método LC-MS/MS Altamente Sensible para la Cuantificación de Barnidipino en Plasma Humano||08/11/2020|
|Rapid DUID screening of 17 drugs of abuse in plasma and saliva||08/11/2020|
|Método LC-MS/MS de cambio de polaridad cuantitativa para pesticidas PPCP en muestras de agua ambiental||07/28/2020|
|Intelligently Designed SWATH Acquisition for Novel Psychoactive Substances (NPS) Detection in Whole Blood||07/23/2020|
|High-sensitivity detection of forensic drug panel in human whole blood||07/23/2020|
|Acidos Haloaceticos Analysis QTRAP 6500 (ES)||07/07/2020|
|Deteccion Rapida y Sensible de 8 Explosivos Organicos en el Suelo Rev (ES)||07/07/2020|
|Análisis de Potencia en Productos de Cáñamo y Cannabis||07/01/2020|
|Compliant attribute monitoring for biopharmaceutical product quality attributes employing intact mass analysis||06/30/2020|
|Sensitive Quantification of Therapeutic Oligonucleotides Extracted from Plasma||05/27/2020|
|Análisis Forense Ultra-Sensible de Cocaína y sus Metabolitos en Muestras de Cabello||05/12/2020|
|Quantitative Analysis of Fentanyl Analogues in Human Whole Blood Utilizing Improved Throughput with Multiplexing Technology||04/23/2020|
|Single-Injection Screening of 664 Forensic Toxicology Compounds||04/08/2020|
|A new approach to testing PPCPs and pesticides in water||04/07/2020|
|Rapid and Sensitive Detection of 8 Organic Explosives in Soil||04/03/2020|
|Picogram Detection of the Marijuana Metabolite THC-COOH in Hair Samples||04/03/2020|
|Ultra-Sensitive Forensic Analysis Workflow of Cocaine and Metabolites in Hair Samples Using LC-MS/MS||04/03/2020|
|Extractables and Leachables Analysis from Laboratory Tubing||04/02/2020|
|Highly Selective and Sensitive Method for Quantification of Nitrosamines in Valsartan Drug Substances||03/17/2020|
|Analysis of Genotoxic Nitrosamines in Losartan and Ranitidine Active Pharmaceutical Ingredients||03/10/2020|
|Highly Sensitive LC-MS/MS Method for Quantification of Barnidipine in Human Plasma||02/27/2020|
|Rapid Identification and Quantification of Performance-Enhancing Stimulants in Human Urine Using High-Resolution Mass Spectrometry||02/25/2020|
|Chemovar Typing of Cannabis Strains with MarkerView and SCIEX X500R QTOF System||02/21/2020|
|A New Level of Compliant-Ready Intact Biotherapeutic Protein Quantitation using Reconstructed Masses||02/19/2020|
|Determination of Beta-agonist Residues in Meat||02/10/2020|
|Targeted analysis of extractables-leachables in drug products containers and closuure systems||02/07/2020|
|Evaluation of Critical Attributes on Different Lots of Adalimumab Using BPV Flex Software 1.0.1||02/06/2020|
|The Quantitative Power of SCIEX Triple Quad and the QTRAP® 6500+ LC- MS/MS System for the Bioanalysis of Biotherapeutics||01/23/2020|
|Increased Throughput for the Characterization of Bispecific Antibodies on Subunit Level using SelexION® Differential Mobility Separation Technology||01/14/2020|
|Rapid Detection of Growth Hormone-Releasing Peptides in Dried Blood Spots: a Proof of Concept Workflow for Anti-Doping Analysis||12/17/2019|
|Forensic Authentication of Hemp-Derived Products Using Mass Spectrometry||12/11/2019|
|Nitrosamines impurity analysis using SCIEX QTRAP 4500 LC-MS/MS System||11/21/2019|
|Next Generation Quality Control in Pharma Applications||11/06/2019|
|Detection of Fentanyl Analogs and Novel Synthetic Opioids in Hair||11/04/2019|
|Authentication and Geographical Origin Analysis of PlantDerived Edible Oil Using the SCIEX X500R QTOF System||10/07/2019|
|Two Nontargeted Screening Approaches for Examination of Drinking Water Before and After Treatment||09/26/2019|
|Quantitative and Qualitative Analysis of Cell Culture Medium Using SWATH Acquisition||09/25/2019|
|Comprehensive characterization of a site-specific antibody-drug conjugate (ADC) by subunit and peptide mapping analysis||09/22/2019|
|Time Course Study of Oxidation Stress Using SCIEX Solution for MAM with the X500B QTOF System||07/30/2019|
|Potency Analysis in Hemp and Cannabis Products||07/25/2019|
|LC-MS/MS Method for the Quantification of Budesonide in Human Plasma||07/02/2019|
|Looking to Expand Drinking Water Testing Capabilities||06/14/2019|
|Analysis of the Canadian Cannabis Pesticides List Using Both ESI and APCI Techniques||06/06/2019|
|Intelligently Designed SWATH Acquisition for Novel Psychoactive Substances (NPS) Detection in Whole Blood||06/04/2019|
|Quantitative Polarity Switching LC-MS/MS Method for Pesticides and PPCPs in Environmental Water Samples||06/02/2019|
|Characterization of AAV capsid proteins with HRMS||05/03/2019|
|Analysis of Kratom’s Main Psychoactive Components||04/15/2019|
|Characterization of 2-AB Labelled Released N linked Glycans Using the X500B QTOF System||04/10/2019|
|Characterization of Intact Monoclonal Antibodies under Native and Reverse Phase Conditions||03/28/2019|
|Rapid Identification and Quantification of Novel Psychoactive Substances in Human Whole Blood Using SWATH® Acquisition||03/26/2019|
|Streamlined Unknown Screening for Postmortem Analysis||03/12/2019|
|Rapid Analysis of Genotoxic Nitrosamines by HPLC-MS-MS||02/25/2019|
|Achieving the California Pesticide Regulations in Cannabis Using Optimized APCI and ESI Techniques||02/20/2019|
|Time Course Study of Oxidation Stress Using SCIEX MAMvSolution with the X500B QTOF System||02/15/2019|
|Isotopically Resolved Subunit Analysis for Tracking Protein Therapeutic Stress Studies||02/02/2019|
|The Overview of LC-MS Quantitative Solutions for Biotherapeutic Analysis||01/23/2019|
|Analysis of the Massachusetts Cannabis Pesticides List Using the SCIEX QTRAP 6500+ System||01/22/2019|
|ExionLC AD Specifications||01/18/2019|
|ExionLC Series Overview||01/02/2019|
|ExionLC AC Series Specifications||12/26/2018|
|ExionLC Series Brochure||12/26/2018|
|Meeting California Cannabis Testing Requirements Using SCIEX LC-MSMS||12/26/2018|
|Highly Selective Bioanalytcal Quantitation Method for Analysis of (R)-Amlodapine and (S)-Amlodapine Enantiomers in Human Plasma using LC-MS/MS||12/06/2018|
|Separation of Bile Acid Isomers with Differential Mobility Spectrometry||12/03/2018|
|Isotopic Resolution of Chromatographically Separated IdeS Subunits Using the X500B QTOF System||08/30/2018|
|Modernizing the Forensic Lab with LC-MS/MS Technology||08/14/2018|
|X500R: Profiling and Identification of Hop-Derived Bitter Compounds in Beer using LC-HR-MS/MS||07/31/2018|
|Quantitation of Dicamba and Acid Herbicides in Agricultural Field Samples on SCIEX QTRAP 6500plus System||07/02/2018|
|Essential LC-MS Performance Kits||06/01/2018|
|User Guide: HPLC System Site Planning Guide (EN)||04/30/2018|
|Intact Analysis of Antibody Drug Conjugates||02/01/2018|
|X500B: Glycosylated and Deglycosylated Subunit Analysis of Antibody Drug Conjugates||12/20/2017|
|Immunoaffinity-High Resolution Accurate Mass Assay for Pre-Clinical Quantification of Trastuzumab in Rat Plasma||12/17/2017|
|Forensics Targeted Analysis using X500R||11/30/2017|
|Elevating the Forensic Laboratory Performance||11/30/2017|
|High Throughput Platform for Confident Identification and Quantitation of Organic Explosives||11/27/2017|
|Increased Throughput for ADME Studies Using the SCIEX ExionLC™ AD UHPLC System||11/15/2017|
|Efficiently Designed Workflows Provide Accurate Results in Forensic Analysis of THC-COOH in Hair||11/06/2017|
|mAb Oxidation Analysis using X500B and Peptide Mapping||10/02/2017|
|Detection of Intact Antibody Impurities on the SCIEX X500B QTOF||09/18/2017|
|Quantitation of Oregon List of Pesticides and Cannabinoids in Cannabis Matrices by LC-MS||08/01/2017|
|SCIEX Success Programs Listing||07/26/2017|
|Quantitation of Microcystins and Nodularins in Water Samples||05/23/2017|
|Routine Workflow for Comparability Assessment of Protein Biopharmaceuticals||04/04/2017|
|Comparative peptide mapping between two manufacturers of Trastuzumab using the X500B QTOF System||04/04/2017|
|Metabolite Identification of Payload Species of Antibody Drug Conjugates with Noncleavable Linkers using MetabolitePilot 2.0 Software and TripleTOF 6600 System||03/16/2017|
|Therapeutic Peptide Catabolite Identification using MetabolitePilot 2.0 Software and the TripleTOF 6600 System||03/16/2017|
|Cannabis for Per Se Law Testing in Whole Blood using theSCIEX Triple Quad QTRAP 4500 LC-MS/MS System||03/06/2017|
|Rapid and Sensitive Analysis of Antibiotics in Children's Urine Using the X500R QTOF System||03/01/2017|
|Analysis of Streptomycin and its Metabolite in Milk Using the SCIEX Triple Quad 3500 System||01/01/2017|
|Quantitation of Chloramphenicol in Milk using SCIEX Triple Quad 3500 LC-MS/MS System||01/01/2017|
|Rapid, Sensitive, Quantitation method for Chloramphenicol in Meat using SCIEX Triple Quad 3500 LC-MS/MS System||01/01/2017|
|Using MS/MS with SWATH Acquisition for Forensic Designer Drug Analysis and SCIEX X500R QTOF System and SCIEX OS Software||12/07/2016|
|Robust and Generic Method for Quantification of Monoclonal Antibody Therapeutics in Biological Matrices||11/01/2016|
|LC-MS/MS Analysis of Emerging Food Contaminants Detection of Glyphosate in Food Samples using QuPPe-LC-DMS-MS/MS||09/01/2016|
|X500R - A Compendium of Related Research Applications||06/01/2016|
|X500R: Identification of Artificial Dyes in Food Using LC-HR-MS/MS Non-Target Screening||05/01/2016|
|X500R: Identification of Hop-Derived Bitter Compounds in Beer Using LC-HR-MS/MS||05/01/2016|
|Perfect Balance to Elevate your Lab’s Performance Using the X500R QTOF System and SCIEX OS Software to Identify and Quantify Food Residues||04/30/2016|
|Quantitation of Cannabinoids and Pesticides in Cannabis Products Using the Triple Quad 3500 LC-MS/MS System||04/20/2016|
|Identification and Quantification X500R||04/12/2016|
|Unknown Screening X500R QTOF||04/12/2016|
|Elevate Lab Performance Using X500R and SCIEX OS to Identify and Quantify Food Residues||04/10/2016|
|Elevate Lab Performance Using X500R and SCIEX OS Software to Quickly Identify Unknowns in Food Samples||04/10/2016|
|Forensic Identifications and Quantification Workflows Delivered on a Revolutionary Designed QTOF and SCIEX OS Software||04/04/2016|
|Efficient Forensic Toxicological Screening and Quantitation Workflow Using QTOF LC-MS/MS System||03/01/2016|
|Fast and Simultaneous Analysis of Ethanol Metabolites and Barbiturates using QTRAP 4500 LC-MS/MS System||02/01/2016|
|User Guide: ExionLC PDA Detector Operator Guide (EN)||10/15/2015|
|LC-MS/MS Analysis of Emerging Food Contaminants (Perfluoroalkyl Acids)||10/01/2015|
|LC-MS/MS Analysis of Emerging Food Contaminants (6500+)||10/01/2015|
|Rapid and Sensitive Analysis of a 93-Compound Forensic Panel in Urine using the QTRAP/Triple Quad 4500 LC-MS/MS System||10/01/2015|
|User Guide: ExionLC System Software User Guide||09/30/2015|
|ExionLC PDA Detector Specifications||09/20/2015|
|ExionLC AC Injection Linearity, Precision and Carryover||09/15/2015|
|User Guide: Systeme ExionLC Guide de Securite||07/31/2015|
|User Guide: ExionLC Degasser Operator Guide (FR)||05/31/2015|
|User Guide: ExionLC Degasser Operator Guide (EN)||05/31/2015|
|Exion LC AD Multiplate Autosampler||05/20/2015|
|ExionLC Rack Changer Specifications||05/20/2015|
|ExionLC UV Detector Specifications||05/20/2015|
|User Guide: ExionLC AC System Hardware User Guide (EN)||04/30/2015|
|User Guide: ExionLC AC System Hardware User Guide (FR)||04/30/2015|
|User Guide: ExionLC AD System Hardware User Guide (EN)||04/30/2015|
|User Guide: ExionLC AD System Hardware User Guide (FR)||04/30/2015|
|User Guide: ExionLC AD Multiplate Sampler Operator Guide (FR)||04/30/2015|
|User Guide: ExionLC PDA Detector Operator Guide (FR)||04/30/2015|
|User Guide: ExionLC Rack Changer Operator Guide (EN)||04/30/2015|
|User Guide: ExionLC Rack Changer Operator Guide (FR)||04/30/2015|
|User Guide: ExionLC UV Detector Operator Guide (EN)||04/30/2015|
|User Guide: ExionLC UV Detector Operator Guide (FR)||04/30/2015|
|User Guide: ExionLC AD Multiplate Sampler Operator Guide (EN)||04/30/2015|
|Routine Methodologies for Detection of Low Abundance Attributes||03/02/2015|
|NGB webinar-HRMS Oligo Quan|
|NGB webinar-SCIEX MAM solution|
|Rapid and Sensitive Detection of 8 Organic Explosives in Soil|
|Targeted and Untargeted Detection of Fentanyl Analogs and Their Metabolites in Hair by Means of UHPLC-QTOF-HRMS|
Your lab has unique analytical requirements and our goal is to provide LC-MS solutions tailored to meet your needs. The ExionLC™ Series of robust and reliable HPLC/UHPLC systems offers a wide range of performance and flexibility.
Make confident decisions faster, resulting in more efficacious, safer therapeutics.
Solutions to test and protect our global food and beverage supply.
Complete forensic drug testing solutions to help you uphold result integrity.
Backed by over 40 years of trusted LC-MS innovation and service, the ExionLC provides you with the versatility, reproducibility and robustness to tackle the toughest applications, from method development to routine analysis, 24/7.
ExionLC AD combines accurate injection volumes with near zero carryover to make quantitation a breeze.
Flow rate precision < 0.06% and accuracy of less than 2% gives you the analytical accuracy and precision you need day in and day out.
The ExionLC AC delivers with its affordable price and HPLC /UHPLC separation capabilities.
Reproducible retention times combined with sensitive, accurate quantitation gives you results you can trust.
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