The SCIEX SelexION device is an innovative achievement in differential ion mobility spectrometry (DMS). This DMS tool delivers highly-selective, robust and powerful ion separation that significantly enhances your quantitative and qualitative performance. Designed to be simple to install without the need to break vacuum on your MS, and compatible with UHPLC timescales, this separation device can help you address your biggest analytical challenges:
For scientists who are challenged by assays with isobaric interferences and difficult-to-separate co-eluting contaminants, this fast, reproducible and easy-to-use approach will enhance the selectivity of your LC/MS/MS separations.
Enhance selectivity without the need for additional complex sample preparation
Perform fast separation analyses compatible with UHPLC timescales
Overcome co-eluting matrix interferences and improve data quality in complex samples
Separate and quantify isobaric molecular species for more accurate biological insights
Maximize mass spec workflow flexibility with easy install that doesn’t require breaking the system vacuum
SCIEX SelexION device is a small, planar mobility cell that significantly increases analytical separation power, even if compounds have identical molecular weights and chromatographic retention times, made possible by a mobility region and optional polar modifiers in the transport region.
Two parallel flat plates define a mobility region, allowing nitrogen carrier gas to create forward directional flow between the ion source and the mass spec analyzer. Analytes are separated based on their respective size, shape, charge state and chemical interaction, prior to entering the mass spec.
Polar modifiers in the transport region can lead to a significant increase in analyte separation and peak capacity. Chemical modifiers, such as isopropanol or acetonitrile, influence ion mobility based on their ability to cluster with analytes.
See how the small, planar SelexION DMS device can enhance analytical separations for isobaric species and co-eluting contaminants.
SelexION offers a unique approach to separation that is unmatched by any other available method. Firstly, it is a planar device that separates ions based on differences in mobility in two different regions of the field dependent mobility curve (Ref 1). Secondly, due to its size, the system can operate with very short residence times with optimal performance when using chemical modifiers, and can be used in transparent mode to allow for maximal workflow flexibility.
Other types of standard low field mobility devices, such as drift tubes, separate ions based upon differences in the low field mobility constant related to analyte mass, and are generally less effective at separating isobaric ions (Refs 2, 3).
Planar devices such as SelexION eliminates heterogeneous electric fields within the device, leading to increased resolving power compared to curved surface mobility devices (Refs 4, 5).
SelexION offers the ability to turn off separation voltage and operate in a ‘transparent’ mode to transmit all ions, providing the option to perform non-ion mobility assays without removing the front-end device (Ref 1).
Used in pharmaceutical, academic and food and environment testing labs across the globe, SelexION DMS technology brings the power of ion mobility to even routine users. The technology is compatible with several SCIEX Triple Quad™, QTRAP® and TripleTOF® platforms. Explore the table below to see what SelexION device is right for your system.
We also offer the SelexION+ ion mobility cell, currently available for use on the SCIEX 6500+ Series mass spectrometers. The SelexION+ device is enhanced by a jet injector that reduces the ion residence time within fringing fields at the DMS inlet. This delivers a 2-fold increase in transmission over the standard SelexION device.
From pharmaceutical drug discovery/development and lipidomic analysis to food, environmental testing and so much more, learn how SelexION technology has enhanced results in these key applications.
SelexION Differential Ion Mobility Technology takes the some of the world's most advanced mass spectrometry systems and adds a new dimension of selectivity to enhance quantitative and qualitative performance. Compatible with any of these SCIEX systems, SelexION device can be installed and uninstalled within 2-minutes without breaking vacuum, giving you the freedom to use the ion mobility technology only when you need to.
Most sensitive and selective system to push quantitation further than ever before
Highest sensitivity high-resolution mass system for comprehensive data acquisition
Better quality data for your lab is just a click away. Consult with us to see how SelexION can help you overcome your biggest challenges.
For research use only. Not for use in diagnostic procedures.
|Differential Mobility Spectrometry Analysis of Glycans and Glycopeptides||01/31/2018|
|Differential Mobility Spectrometry Theory||12/20/2017|
|Selexion dms technology increasing the selectivity of lc msms analysis||12/06/2017|
|Omics Applications-SelexION® Differential Mobility Spectrometry Technology||10/11/2017|
|User Guide: SelexION and SelexION+ Technology Troubleshooting||09/30/2017|
|Bioanalysis Quantitation Applications eBook||09/25/2017|
|Determination of Limaprost in Human Plasma||09/13/2017|
|Selexion Valproic Acid Tech Note||08/31/2017|
|Differential Mobility Separation with SCIEX SelexION Technology – A Novel Technique for the Bioanalysis of Poor Fragmenting Molecules Like Valproic Acid||06/29/2017|
|The Use of SelexION® to Increase Sensitivity for Trace Level Analysis of Small Polar Molecules||06/21/2017|
|Differential Mobility Spectrometry Resolves Isobaric Metabolite Overlap||06/15/2017|
|SCIEX Quantitation and Metabolism Solutions Brochure||05/26/2017|
|SelexION Differential Ion Mobility Technology||05/01/2017|
|SelexION Differential Ion Mobility Intro||04/10/2017|
|SelexION Differential Mobility Technology Address your Biggest Analytical Challenges||04/01/2017|
|Advanced Biotransform Solution Guide||03/28/2017|
|Differential Mobility Spectrometry Resolves Chlorine- and Acetate- Adducts of Phosphatidylcholine (PC)||12/10/2016|
|Dysregulated Lipid Profiles of Non-Alcoholic Fatty Liver Disease (NAFLD)||12/05/2016|
|Differential Mobility Separation for Improving Lipidomic Analysis by Mass Spectrometry||12/01/2016|
|Differential Mobility Separation Mass Spectrometry for Quantitation of Large Peptides in Biological Matrices||12/01/2016|
|SelexION ION Mobility Technology - A New Dimension in Selectivity||11/28/2016|
|Solutions for Biotherapeutic Characterization||09/01/2016|
|BioBA Solution Infographic||06/15/2016|
|LC-MS/MS Quantitation of Underivatized Glyphosate and Other Polar Pesticides||06/01/2016|
|Novel Chemical Standards Kits Enable Facile Lipid Quantitation||05/01/2016|
|SelexION Series Ion Mobility System Declaration of Conformance||04/20/2016|
|Separation of Diastereomeric Flubatine Metabolites using SelexION® Technology||02/23/2016|
|Quantification of Peptides with Poor MS/MS Fragmentation using Novel Jet Injector SelexION® + MIM Workflow||01/31/2016|
|Automating Optimization of Compensation Voltages for Differential Mobility Separation using Skyline||12/11/2015|
|Multiple Mass Spectrometric Strategies for High-Selectivity Quantification of Proteins and Peptides||12/02/2015|
|Rapid Quantitation of Substance P in Plasma using Differential Mobility Spectrometry and Micro Flow Liquid Chromatography||12/01/2015|
|Using Differential Mobility Spectrometry to Separate and Localize Sites of Post-Translational Modifications on Peptides||11/01/2015|
|Resolution of Ether and Diacyl-Linked Phospholipids by Differential ION Mobility Spectrometry (DMS)||09/01/2015|
|Quantitative Lipid Analysis using MRM and Differential Ion Mobility Spectrometry (DMS)||09/01/2015|
|Resolution of Sphingomyelins in Complex Lipid Extracts by Differential Ion Mobility Spectrometry (DMS)||09/01/2015|
|User Guide: SelexION Technology for 5500 and 6500 Systems and SelexION+ Technology for 6500+ Systems User Guide||08/31/2015|
|User Guide: SelexION Technology for 5500 and 6500 Systems and SelexION+ Technology for 6500+ Systems User Guide (ES)||08/31/2015|
|User Guide: SelexION Technology for 5500 and 6500 Systems and SelexION+ Technology for 6500+ Systems User Guide (IT)||07/31/2015|
|User Guide: SelexION Technology for 5500 and 6500 Systems and SelexION+ Technology for 6500+ Systems User Guide (DE)||07/31/2015|
|User Guide: SelexION Technology for 5500 and 6500 Systems and SelexION+ Technology for 6500+ Systems User Guide (FR)||07/31/2015|
|User Guide: SelexION Technology for 5500 and 6500 Systems and SelexION+ Technology for 6500+ Systems Site Planning Guide||06/30/2015|
|User Guide: SelexION Technology for 5500 and 6500 Systems and SelexION+ Technology for 6500+ Systems Site Planning Guide (DE)||06/30/2015|
|User Guide: SelexION Technology for 5500 and 6500 Systems and SelexION+ Technology for 6500+ Systems Site Planning Guide (FR)||06/30/2015|
|User Guide: SelexION Technology for 5500 and 6500 Systems and SelexION+ Technology for 6500+ Systems Site Planning Guide (IT)||06/30/2015|
|User Guide: SelexION Technology for 5500 and 6500 Systems and SelexION+ Technology for 6500+ Systems Site Planning Guide (ES)||06/30/2015|
|User Guide: SelexION Technology for TripleTOF Systems User Guide||05/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems User Guide (DE)||05/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems User Guide (IT)||05/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems User Guide (FR)||05/31/2015|
|SelexION Technology for TripleTOF Systems User Guide (ES)||05/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems Site Planning Guide (DE)||03/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems Site Planning Guide||03/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems Site Planning Guide (FR)||03/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems Site Planning Guide (IT)||03/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems Site Planning Guide (ES)||03/31/2015|
|Caring for TurboV Ion Source Electrodes||01/01/2014|
|Triple Quad™ 5500 LC/MS/MS System and SelexIONTM technology||01/01/2014|
|Differential Ion Mobility Separation of Iso-Elemental Lipid Species||03/01/2012|
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