AB Sciex is doing business as SCIEX. © 2010-2019 AB Sciex. The trademarks mentioned herein are the property of the AB Sciex Pte. Ltd. or their respective owners. AB SCIEX™ is being used under license. Beckman Coulter® is being used under license. Product(s) may not be available in all countries. For information on availability, please contact your local representative. For research use only. Not for use in diagnostic procedures.
Take on new analytical challenges and extend your research capability with the TripleTOF® 6600 Quadrupole Time-Of-Flight (QTOF) mass analyzer.
Built with versatility in mind, the TripleTOF technology unleashes sensitivity, speed, and productivity in a single multifaceted platform to help you dig deeper into complex samples. Ultra-fast acquisition rates allow you to collect high-resolution MS/MS data on every detectable analyte in your sample, giving you the potential you need to advance your research.
Power Your Workflows with High-Resolution Accurate Mass LC-MS
Check out how SCIEX customers are using the TripleTOF 6600 System in these scientific publications.
Powered by BIOZ, the world's first search engine for life science experimentation. Their cloud platform combines the work of scientists with AI technologies to help life scientists make faster and smarter experimentation decisions.
These scientific articles are supplied by a third-party resource and have not been evaluated by SCIEX. Articles are provided as-is and without warranty of any kind, including intellectual property rights and reported issues.
Taking Mass Spec Analysis to the Edge
With more ions produced, better ion focusing, improved ion reflection and maximized detection, you will experience the performance edge with the TripleTOF 6600 system. Optimized instrument control electronics in conjunction with patented LINAC collision cell technology delivers ultra-fast acquisition rates of up to 100 MS/MS per cycle for IDA mode and 200 MS/MS per cycle for SWATH® data-independent acquisition, without compromising resolution.
Take on new challenges and projects by choosing a platform that offers maximum versatility. Quickly get up and running with new workflows by employing a familiar system with the widest breadth of applications available.
For research use only. Not for use in diagnostic procedures.
|Case Study- Nico van de Merbel- PRA Health Science||04/08/2019|
|Characterization of Intact Monoclonal Antibodies under Native and Reverse Phase Conditions||03/28/2019|
|Microflow SWATH Acquisition for Industrialized Quantitative Proteomics||03/11/2019|
|SWATH Acquisition Allows a Deeper Level of Comprehensive Metabolite Quantitation||03/08/2019|
|MS-DIAL Data Processing for Untargeted Metabolomics||02/28/2019|
|Native Analysis of Intact Monoclonal Antibody Aggregates Using the TripleTOF 6600 System||02/15/2019|
|Digitizing the Proteomes From Big Tissue Biobanks||12/26/2018|
|High-throughput Lipid Profiling with SWATH Acquisition and MS-DIAL||12/21/2018|
|Host Cell Protein Knowledge Accelerator||12/05/2018|
|Resolution of Ether and Diacyl-Linked Phospholipids by Differential ION Mobility Spectrometry (DMS)||11/19/2018|
|Metabolomics Online Symposium Cajka||10/16/2018|
|Method Optimization for a Multiple Attribute Method Using the TripleTOF 6600 Mass Spectrometer||10/09/2018|
|Highly Robust and Sensitive SPE-LC-HRMS Workflow for Quantifying KR Rich Peptide RTP004 in Rat Serum||06/30/2018|
|User Guide: NanoSpray Ion Source Operator Guide (IT)||05/31/2018|
|User Guide: NanoSpray Ion Source Operator Guide (DE)||05/31/2018|
|User Guide: NanoSpray Ion Source Operator Guide (FR)||05/31/2018|
|User Guide: NanoSpray Ion Source Operator Guide (EN)||05/31/2018|
|SWATH-MS HCPs Profiling and Absolute Quantification of Key Impurities||05/23/2018|
|Method Development 101-How Easy Can Implementation Be||05/15/2018|
|Detection and Definition of Attributes in a Multiple Attribute Method with BioPharmaView Software 3.0||05/10/2018|
|Multiple Attribute Methodology (MAM) by LC-MS TT6600||05/01/2018|
|BioPharmaView Software 3.0 Product Bulletin||05/01/2018|
|Streamlined and Complete LC-MS Workflow for MAM||05/01/2018|
|Simplifying the Use of Ion Libraries during Data Processing of SWATH Acquisiton Proteomics Data||04/10/2018|
|Ion Source Tests, Specifications, and Data Log||03/10/2018|
|CESI-MS Sensitive and Versatile Approach for Metabolomics and Polar Molecules||02/20/2018|
|SCIEX TripleTOF 6600 Declaration of Conformance||02/16/2018|
|Streamlining Discovery Microsomal Clearance and Metabolite ID Analysis using SCIEX TripleTOF 6600||02/15/2018|
|Defining and Tracking Biopharmaceutical Attributes Using the BioPharmaView Software 3.0 MAM workflow||02/10/2018|
|OptiFlow Interface on the TripleTOF 6600 system||02/05/2018|
|OptiFlow Interface for TripleTOF® 6600 System||02/01/2018|
|Intact and reduced therapeutic monoclonal antibodies||01/25/2018|
|Studying Quality Attributes of Adalimumab by Mass Spectrometry||01/10/2018|
|Analysis of Intact Monoclonal Antibodies Using an M3 MicroLC with the TripleTOF 6600||01/05/2018|
|Isotope Ratio Outlier Analysis (IROA) and Variable Window SWATH® Acquisition||01/02/2018|
|Reproducible Peptide Mapping of Biotherapeutics with SWATH Acquisition on the TripleTOF 6600 System and BioPhamaView Software||12/27/2017|
|Multi-Omics Analysis of Human Embryonic Stem Cell Neural Differentiation||12/22/2017|
|SWATH Acquisition Improves Metabolite Coverage over Traditional Data Dependent Techniques for Untargeted Metabolomics||12/22/2017|
|User Guide: TripleTOF 6600 System User Guide||12/20/2017|
|User Guide: TripleTOF 6600 System User Guide (FR)||12/20/2017|
|User Guide: TripleTOF 6600 System User Guide (IT)||12/20/2017|
|User Guide: TripleTOF 6600 System User Guide (DE)||12/20/2017|
|User Guide: TripleTOF 6600 System Qualified Maintenance Person Guide||12/20/2017|
|User Guide: TripleTOF 6600 System Qualified Maintenance Person Guide (DE)||12/20/2017|
|User Guide: TripleTOF 6600 System Qualified Maintenance Person Guide (FR)||12/20/2017|
|User Guide: TripleTOF 6600 System Qualified Maintenance Person Guide (IT)||12/20/2017|
|User Guide: IonDrive Turbo V Ion Source Operator Guide (IT)||12/20/2017|
|User Guide: IonDrive Turbo V Ion Source Operator Guide (FR)||12/20/2017|
|User Guide: DuoSpray Ion Source for TripleTOF Systems Operator Guide (FR)||12/20/2017|
|User Guide: DuoSpray Ion Source for TripleTOF Systems Operator Guide (IT)||12/20/2017|
|User Guide: Turbo V Ion Source Operator Guide (ES)||12/20/2017|
|User Guide: Turbo V Ion Source Operator Guide (PL)||12/20/2017|
|User Guide: Turbo V Ion Source Operator Guide (PT)||12/20/2017|
|Turbo V Ion Source Operator Guide (RU)||12/20/2017|
|Turbo V Ion Source Operator Guide (ZH)||12/20/2017|
|Turbo V Ion Source Operator Guide (JA)||12/20/2017|
|User Guide: Turbo V Ion Source Operator Guide (IT)||12/20/2017|
|User Guide: Turbo V Ion Source Operator Guide (FR)||12/20/2017|
|Automated HIgh Throughput Trypsin Digests for HIghly Reproducible Peptide Map Analysis||12/20/2017|
|User Guide: IonDrive Turbo V Ion Source Operator Guide (ES)||12/20/2017|
|User Guide: TripleTOF 5600/5600+ System Qualified Maintenance Person Guide (ES)||12/20/2017|
|User Guide: TripleTOF 5600/5600+ Instruments System User Guide (ES)||12/20/2017|
|User Guide: TripleTOF 6600 System Qualified Maintenance Person Guide (ES)||12/20/2017|
|User Guide: TripleTOF 6600 System User Guide (ES)||12/20/2017|
|Enabling Single-Software Multiple Attribute Methodology (MAM) for assessment of Biopharmaceutical Product Quality Attributes||12/20/2017|
|Expanding Suspect Screenig and Non-Targeted Identification||12/20/2017|
|Dont miss Synthetic Drug Present in Sample||12/20/2017|
|Immunoaffinity-High Resolution Accurate Mass Assay for Pre-Clinical Quantification of Trastuzumab in Rat Plasma||12/17/2017|
|Application of Data Independent Acquisition for Top-Down Characterization of IgG Light Chain||12/15/2017|
|Improved Data Quality Using Variable Q1 Window Widths in SWATH Acquisition||12/11/2017|
|Ultra-sensitive Host Cell Protein Dection using CESI-MS with SWATH Acquisition||12/10/2017|
|Over 17K Compounds Available-X500R and Spectral Libraries||12/10/2017|
|Extending Metabolome Coverage-untargeted Metabolomic Workflows||12/05/2017|
|IonDrive Turbo V Ion Source Operator Guide (DE)||10/10/2017|
|IonDrive Turbo V Ion Source Operator Guide (EN)||10/10/2017|
|DuoSpray Ion Source for TripleTOF Systems Operator Guide (EN)||10/10/2017|
|DuoSpray Ion Source for TripleTOF Systems Operator Guide (DE)||10/10/2017|
|Turbo V Ion Source Operator Guide (DE)||10/10/2017|
|Turbo V Ion Source Operator Guide (EN)||10/10/2017|
|TripleTOF 6600 System Site Planning Guide (EN)||10/10/2017|
|TripleTOF 6600 System Site Planning Guide (DE)||10/10/2017|
|TripleTOF 6600 System Site Planning Guide (ES)||10/10/2017|
|TripleTOF 6600 System Site Planning Guide (FR)||10/10/2017|
|TripleTOF 6600 System Site Planning Guide (IT)||10/10/2017|
|User Guide: SelexION and SelexION+ Technology Troubleshooting||09/30/2017|
|Advanced Biotransform Solution: Sensitive Microflow Analysis of Peptide Catabolism||09/15/2017|
|CloudConnect Auto Uploader||09/12/2017|
|TripleTOF 6600 3D Animation||08/10/2017|
|TripleTOF 6600 Flyer||08/10/2017|
|Solutions for Biotherapeutic Characterization||08/01/2017|
|Novel Labeled Metabolomics Workflow applying Isotope Ratio Outlier Analysis (IROA) and SWATH Acquisition for Unambiguous Compound Identification||07/06/2017|
|Using Multi-Omics Analysis to Study EMT Model of Prostate Cancer||06/04/2017|
|Proteome-wide Profiling of Drug Dose-Response in Prostate Cancer Cell Lines by Microflow SWATH Acquisition||06/04/2017|
|Dev of Hi-Throughput Proteomics Pipeline-SWATH Profiling Biochemical Individuality||06/04/2017|
|SCIEX Quantitation and Metabolism Solutions Brochure||05/26/2017|
|Die Bedeutung der LC-HRMS bei der Sicherung der Trinkwasserqualität||05/24/2017|
|MetabolitePilot Software 2.0||05/04/2017|
|Advanced Biotransform Solution Guide||03/28/2017|
|Metabolite Identification of Payload Species of Antibody Drug Conjugates with Noncleavable Linkers using MetabolitePilot 2.0 Software and TripleTOF 6600 System||03/16/2017|
|Therapeutic Peptide Catabolite Identification using MetabolitePilot 2.0 Software and the TripleTOF 6600 System||03/16/2017|
|CESI 8000 Plus paired with the TripleTOF 6600 for the analysis of Protein Therapeutics||02/28/2017|
|Accelerating Protein ID for Deep Proteome Profiling||01/01/2017|
|MarkerView Software 1.3 New Features||12/15/2016|
|M3 MicroLC for TripleTOF-Test and Data Log||12/10/2016|
|M3 MicroLC-TE for TripleTOF-Test and Data Log||12/10/2016|
|Assessing Impact of Extended Gradient Lengths for Microflow SWATH Acquisition||09/15/2016|
|Why Compromise-The Benefit of High-Resolution Quantitative Analysis||09/15/2016|
|NanoLC Systems for TripleTOF systems Test and Data Log||09/01/2016|
|PCT-SWATH for Protein Quantitation-Tissue to Peptids in 4 Hours||07/01/2016|
|Accelerating Data Independent Acquisition with Microflow Chromatography||06/06/2016|
|Improving DIA Quantitation with microLC Using a Longer Gradient||06/06/2016|
|Host Cell Protein Analysis by Microflow-LC High Resolution SWATH-MS of Vaccine Samples Under Development||06/06/2016|
|Comprehensive Relative Quantification of the Cytochromes P450 by Micro-LC and SWATH Acquisition||06/06/2016|
|Drug Metabolism-Chging landscape||05/15/2016|
|UHPLC-ESI-QTOF-MS/MS based Lipidomics by Data-independent Acquisition||05/11/2016|
|Studying Kinetics of Chromatin Assembly with SWATH MS||05/11/2016|
|The Lipidyzer- a new platform for quantitative Lipidomics||05/11/2016|
|CESI-MS a technique for the characterization and analysis of both intact and digested biopharmaceuticals||05/11/2016|
|industrializing omics-SCIEX Life Science Research towards Precision Medicine||05/01/2016|
|Innovation for Biotherapeutic Comparability with BioPharmaView Software Solution Guide||05/01/2016|
|Simultaneous analysis of 12 food allergens in baked and raw food products using the LC-MS/MS QTRAP 4500 system||05/01/2016|
|BioPharmaView Software Overview Video||05/01/2016|
|Industrializing Quantitative Proteomics Using Microflow LC and SWATH Acquisition||04/27/2016|
|User Guide: TripleTOF Systems Electromagnetic Environment Information||04/20/2016|
|Understanding Complex Lipid Metabolism through Quantitative Lipidomics||03/15/2016|
|Host cell protein detection using CESI-MS with SWATH||02/09/2016|
|Unification of Charge Heterogeneity, Purity, and Molecular Weight Analyses of mAbs into a Single Analysis||12/05/2015|
|Eksigent MicroLC 200/200 Plus Systems||10/05/2015|
|High-Throughput SWATH-MS for Biopsy-Level Samples||09/15/2015|
|Next-Generation Proteomics Platform||08/01/2015|
|Ultra-sensitive Host Cell Protein Detection using CESI-MS with SWATH Acquisition||06/01/2015|
|User Guide: SelexION Technology for TripleTOF Systems User Guide||05/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems User Guide (DE)||05/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems User Guide (IT)||05/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems User Guide (FR)||05/31/2015|
|SelexION Technology for TripleTOF Systems User Guide (ES)||05/31/2015|
|Investigating Relationship btwn Biological Variability and Biomarker Discovery by SWATH MS||05/21/2015|
|User Guide: SelexION Technology for TripleTOF Systems Site Planning Guide||03/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems Site Planning Guide (DE)||03/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems Site Planning Guide (FR)||03/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems Site Planning Guide (IT)||03/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems Site Planning Guide (ES)||03/31/2015|
|Spectral Libraries for Food Analysis - Antibiotics||03/05/2015|
|Spectral Libraries for Food Analysis - Pesticides||03/05/2015|
|Announcing SWATH® Acquisition 2.0||06/12/2014|
|Innovations in Biologics||06/01/2014|
|Next-Generation Proteomics Platform||06/01/2014|
|User Guide: Calibrant Delivery System Operator Guide||06/01/2014|
|User Guide: Calibrant Delivery System Operator Guide (DE)||06/01/2014|
|User Guide: Calibrant Delivery System Operator Guide (FR)||06/01/2014|
|User Guide: Calibrant Delivery System Operator Guide (IT)||06/01/2014|
|TripleTOF HRMS System Features for Screening Unknown Contaminant in Foods||03/04/2014|
|Instrument Front-End Cleaning Procedure Manual||10/01/2013|
|Rapid and Unbiased Quantitation of Host Cell Protein Contaminants in Biologics by MSMS of All Using a TripleTOF Mass Spectrometer||09/24/2013|
|Advancing your Forensic Toxicology Analyses; Adopting the Latest in Mass Spectrometry Innovations||07/01/2013|
|Increasing the Multiplexing of High Resolution Targeted Peptide Quantification Assays||01/01/2012|
|ImpurityPilot Software 1.0 Beta||08/01/2011|
|User Guide: NanoSpray Head and Emitter Tip Assembly Quick Start Guide|
|Microflow SWATH Acquisition for Industralized Quantitative Proteomics|
|BioPharamaView 3.0:End to End Software for MAM Workflows|
|Simplifying the Use of Ion Libraries During Data Processing of SWATH Acquisition Proteomics Data|
|Multi-Omics analysis of Human Embryonic Stem Cell|
Analyze your complex samples faster without compromising between speed, resolution and sensitivity. Identify and quantify your sample components more comprehensively across a broad dynamic range of concentrations with the high-resolution MS/MS, at ultra-fast acquisition speeds.
Balance throughput and sensitivity for large scale proteomics studies with Microflow SWATH.
Analyze multi-omic datasets, boost processing power, and visualize biological results with OneOmics™ cloud based tools.
Obtain high-quality quantitation with MRMHR workflow, for targeted analysis of proteins, lipids or small molecule metabolites.
Broadly profile large numbers of lipids with the unique Infusion MS/MSALL workflow.
From qualitative characterization experiments to high quality quantitation, this system gives you the power, sensitivity and flexibility to support and advance your therapeutic discovery and development pipeline.
Be confident you’re not missing low level or toxic metabolites or catabolites in your sample
Identify low level host cell proteins you didn’t know existed using data-independent SWATH® Acquisition
Sensitivity and large dynamic range enables sequence variant detection during biotherapeutic development
Gain additional selectivity for quantitation by utilizing high-resolution MS/MS data
Perform biologic product quality attribute monitoring and quantitation, known impurity tracking, and unspecified impurity testing with a streamlined and complete workflow for MAM
Couple the most advanced hardware platform with industry leading software processing, and you will accelerate discoveries across multiple applications, from proteomics, metabolomics and lipidomics to food/environmental screening and biologics characterization.
Process your SWATH data faster, and integrate multi-omics data seamlessly and securely in one place
Enhance your proteomic studies with rigorous enhanced database searching and confident protein assignments
Accelerate biologics and biosimilar characterization with powerful data processing for core characterization applications and Multiple Attribute Methodology workflows
Interpret your metabolism and biologic catabolism data faster with high-throughput processing
Whether you need the highest sensitivity of CESI or NanoLC for biomarker discovery experiments, or higher flow rates for throughput and robustness, the TripleTOF system offers complete flexibility so it can be configured to meet your specific workflow needs. Coupled with industry leading software packages for fast data to results, the TripleTOF is the one system that is versatile enough to answer all your questions.
Achieve enhanced separation with integrated capillary electrophoresis (CESI)
The most flexible low flow LC system, offering high reproducibility across a wide flow rate range
Optimized MicroLC system for high-throughput workflows and limited sample volumes
Analytical flow LC with superior expandability, robustness and carryover performance
Fast, reproducible and easy-to-use ion mobility device for heightened selectivity
|Mass Range TOF||5 – 40,000 m/z|
|Mass Selection Range Q1||5 – 2250 m/z|
|TOF-MS Mass Resolution and Acquisition Speed||≥35,000 (FWHM) at 956 m/z, using 10 ms accumulation time|
|TOF-MS/MS Mass Resolution and Acquisition Speed||≥30,000 (FWHM) at 813 m/z, and ≥25,000 (FWHM) at 195 m/z, using 10 ms accumulation time|
|Detector Type||4-channel MCP detector with ADC signal processing for extended dynamic range|
|Flexible Data Acquisition Workflows|| TOF-MS
Information dependent acquisition (IDA) MS/MS
Data Independent SWATH® Acquisition with fixed or variable Q1 isolation windows
Targeted MRMHR workflow
|Ionization Sources||IonDrive™ Turbo V, DuoSpray™ source, each with TurboIonSpray® or Atmospheric-pressure chemical ionization (APCI) probes available; NanoSpray® III source, Digital PicoView NanoSource|
|Orthogonal Front End Separation Compatibility||Compatible with advanced front-end separation strategies including high-flow, microflow and nanoflow chromatography, capillary electrophoresis spray ionization (CESI), or using SelexION® differential ion mobility|
|Variable Window SWATH® Acquisition||Data-Independent SWATH® Acquisition with variable window capabilities, allows for a large number of Q1 isolation windows at user controlled widths, up to 200 per cycle to achieve better specificity, even in complex samples. Read More|
|Data File Portability||Condensed data file sizes simplify and streamline data storage and portability for sharing with colleagues, without losses in data quality, completeness or security|
The new design of the legendary Turbo V source increases ion production by using enhanced gas flow dynamics and optimized heater configuration to improve reliability, reproducibility, and robustness at higher flow rates.
Designed for robustness, the QJet Ion guide provides large capture radius for efficient transfer of ions from source to quadrupole optics.
High drive frequency collision cell provides better ion transmission, higher duty cycle, and improved resolution by focusing ions prior to entering TOF.
Time-of-flight analyzer uses a 2-stage mirror and 15 kV acceleration to improve resolution and efficiency. Get the speed and sensitivity required for triple quadrupole like quantitation, but with high resolution and mass accuracy for qualitative applications.
4-channel MCP detector with ADC processing technology provide more than 5-orders of linear dynamic range while improving robustness and lifetime at high ion currents.
Blog: Industrialize your Proteomics with Microflow SWATH Acquisition
Blog: Host Cell Protein Contaminants Can’t Hide from SWATH Acquisition
Technical Note: Streamlining Metabolite ID with SWATH Acquisition"
Technical Note: Analysis of Intact mAbs using MicroLC and TripleTOF 6600
Blog: Get to your Metabolomics answer faster with TripleTOF 6600 and the Accurate Mass Metabolomics Library
Webinar: Solutions for Metabolomics and Lipidomics Research
Get more out of every sample with an additional dimension of separation with SelexION® Differential Ion Mobility Technology.
Efficient ion production while limiting contamination for maximized robustness, reliability and uptime.
Variable window capabilities allow for a large number of Q1 isolation windows at user controlled widths, up to 200 per cycle to achieve better specificity, even in complex samples.
Compatible with advanced front-end separation strategies including high-flow, microflow and nanoflow, and capillary electrophoresis spray ionization (CESI).
Comprehensive and proven solutions to obtain and analyze large amounts of data accurately.
Translate your research into biological knowledge with a complementary portfolio of solutions to measure, process, characterize metabolites.
Capture and analyze 1000s of cellular lipids to identify biomarkers and clarify cellular metabolism at the lipid level.
Fast and efficient metabolic stability, soft spot analysis and in-depth, comprehensive identification of metabolites and catabolites in a sample.
Succeed in the face of escalating workloads and more complex biotherapeutic characterization demands.
Overcome challenges of low-level host cell proteins (HCP), assuring safe biotherapeutic development with proven technologies to help boost productivity.
Test and protect our global food and beverage supply with solutions that address the needs of food scientists, producers, and regulators.
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