Preventing IP Address Conflicts with SCIEX 5500/6500+ Series MS and Waters' Acquity LC Instruments

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Use-Waters-DHCP-configurator-For-IP-address-change_en_US

To eliminate the possibility of any IP address conflict, the Waters IP addresses should be changed when operating with a SCIEX 5500/6500+ series instrument. To change the IP address on a Waters' LC components, use the Waters DHCP configurator located in the following folder: C:\\Program Files\Waters Instruments\Waters DHCP Server Configuration.exe.

For research use only. Not for use in diagnostic procedures.

Issue Description

SCIEX's 5500/6500+ series MS instruments and Acquity LC components both use a similar IP address: 192.168.x.x. There is strong evidence that any similarity between the instruments' IP addresses can lead to communications problems. To eliminate the possibility of any IP address conflicts, the Waters IP addresses should be changed when a 5500//6500+ is present.

Resolution

To change the IP address on a Waters' LC components, use the Waters DHCP configurator located in the following folder: C:\\Program Files\Waters Instruments\Waters DHCP Server Configuration.exe.

Run the configurator file and select Configure DHCP.
From the server pull down menu, select Configuration Wizard.
Select the Acquity instrument LAN1, and click next.
Select the alternate IP address of 172.16.0.1 and click next.
Click finish, and the PC will reboot.
Power cycle all of the Acquity components. The reconfigured network card will hand out new addresses to the Acquity LC modules as they power up.

Online

Updated

en_US

2026-03-02

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Issue_and_Resolution