The SCIEX clinical diagnostic portfolio is For In Vitro Diagnostic Use. Rx Only. Product(s) not available in all countries. For information on availability, please contact your local sales representative or refer to https://sciex.com/diagnostics. All other products are For Research Use Only. Not for use in Diagnostic Procedures.
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SWATH® Acquisition is the ultimate approach to immortalize a sample by creating a digital data record of all observable species. Since before the initial release in 2010, SWATH® Acquisition has been continually developed in collaboration with customers. The next chapter to this story will land in June 2019, allowing you to play your part in the development of game-changing data-independent analysis for the future.
Variable window Q1 SWATH rolled out as a beta scheme. Customer input guides further development into final SWATH 2.0 solution.
Multi-lab study published in Nature Communications, shows large-scale quantitative reproducibility across 11 participating labs.
Beta Scanning SWATH® Acquisition to be launched, such that further development and data processing approaches can be guided by customer users.
The next chapter in the SWATH story takes this concept even further by allowing every single MSMS iteration to be acquired and directly correlated to the correct precursor. The data produced by Scanning SWATH® Acquisition therefore contains all the information that would be contained in a multitude of different experimental approaches combined in a single all-encompassing dataset.
SCIEX TripleTOF® platforms are known for their high acquisition speeds and superior data quality even at the fastest scan rates. Scanning SWATH® Acquisition allows the user to exploit these scanning speeds, enabling rapid data-independent acquisition that is compatible with fast chromatography with no method development. Fast scanning quadrupole scan moves an overlapping Q1 window through the m/z range, acquiring all MS/MS fragments, allowing a multidimensional dataset to be collected with more data points.
By scanning through the m/z range instead of stepping, while acquiring MSMS at very fast acquisition rates, Scanning SWATH is able to capture every conceivable MSMS event in a manner where every fragment can be directly correlated to its precursor, meaning that data can be interrogated in a wide variety of ways. The extra dimension of data interpretation achieved through this correlation gives increased confidence in identification for both quantitative and qualitative discovery workflows.
Scanning SWATH produces the ultimate multi-dimensional dataset, containing fully correlated MS and MSMS data on all observable species, which can be processed and interpreted in a variety of ways depending on the goal. The specificity of the approach means that the dataset can be treated quantitatively as a repository of SRMs of every observable precursor, while the ability to correlate these transitions back to their precursor gives improved confidence in identification. Additionally, fast scanning of the quadrupole allows discovery approaches such as precursor ion and neutral loss information to be extracted from the dataset for any observable feature.
Beta Scanning SWATH® Acquisition comes exclusively to the new TripleTOF® 6600+, offering the ultimate combination of flexibility and quantitative power. A system with the capability of delivering speed, scale, and depth of coverage for quantitative studies, whether a few samples or a cohort containing thousands.
Find out how variable window SWATH® Acquisition has advanced quantitative proteomics.
Discover the wealth of quantitative applications that can be delivered using SWATH® Acquisition.
For research use only. Not for use in diagnostic procedures.
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