Overview
The promise of cell therapy is staggering, bringing the possibility of a better life and even cures for diseases that were previously lethal. This promise requires the highest quality intermediate products, such as viral vectors, LNPs and CRISPR gene editing tools used for cell re-programming, and the need to understand the wider effects on the proteome.
Pursue improvements in medicine with a reliable partner for your analytical needs.
Workflow
Lentivirus characterization
Lentiviral vectors are complex modalities with quality that is linked to multiple attributes. User-friendly workflows let you determine viral protein profiles, including titer, genome integrity and nucleic acid impurities, on a single platform. Limitations on identifying host cell proteins can be overcome by solutions that offer the highest data quality.
Move your viral vector-based cell therapies forward with confidence.
Lentivirus characterization
Solution
- Assessment of protein profiles, titer, genome integrity and purity
- Faster method development and larger sample sets
Lentivirus characterization
Solution
- Assessment of protein profiles, titer, genome integrity and purity
- Smaller sample sets
Featured resources
Take control of the quality of your lentiviral vectors with high-performance solutions. Learn how to characterize proteins, determine protein profiles, and enhance your understanding of process changes with intuitive wor
Lentivirus characterization
Solution
Workflow
Cell therapy proteome analysis
Information on gene inserts, regulatory regions, and nuclease sites of pDNA is important for investigational new drug (IND) submissions for viral vectors and protein therapeutics. Furthermore, poly-A tails for IVT mRNA are frequently encoded in the pDNA template and their lengths and potential heterogeneity require assessment.
While these attributes can be analyzed with restriction fragment assays, accurate and reproducible sizing over an extended size range are challenges analytical scientists face.
Cell therapy proteome analysis
Solution
All resources
Take control of the quality of your lentiviral vectors with high-performance solutions. Learn how to characterize proteins, determine protein profiles, and enhance your understanding of process changes with intuitive workflows.
Associated applications
CRISPR/Cas9 analysis
Set your own schedule for CRISPR/Cas9 gene editing with innovative, intuitive analytical solutions. Unleash the potential of your Cas9 messenger RNA (mRNA), single guide RNA (sgRNA) and Cas9 proteins by understanding quality, purity and safety and assessing on/off target effects.
Lipid nanoparticles and non-viral carriers
Expand the possibilities of drug delivery with innovative analytical solutions for lipid raw materials, LNPs and other non-viral carriers. Move beyond boundaries in structural elucidation and monitoring of analytes to estabilish confidence in the quality and stablity of your products.
Residual nucleic acid analysis
Optimize workflows to reliably detect and monitor process-related impurities. Ensure the safety of next-generation viral products with accurate, reproducible sizing of residual DNA and RNA and simultaneous quantitation.
Viral vector characterization
Optimize your processes with solutions that overcome the analytical challenges of viral vector-based drugs. Take control of full and empty ratios and protein and genome profiles. Break down the boundaries of protein and post-translational modification (PTM) characterization with dedicated high-resolution workflows offering unprecedented depth.