Discover innovations that can help accelerate your drug discovery and development programs

Developers of current and next generation biopharmaceuticals are challenged to provide increasingly deeper characterization of inherently more complex molecules.

Electron activated dissociation (EAD) and Zeno trap capability in the ZenoTOF 7600 system enables a new level of confidence and insight for the characterization of your most challenging biotherapeutics. Access technical notes, webinars and white papers to learn how you can:

  • Dramatically increase fragment ion coverage for better peptide maps that include low abundance, labile PTMs
  • Quickly and accurately produce intact and subunit results, that you can be confident in
  • Achieve base-specific localization and identification of a wide variety of PTMs across all charge states
  • Obtain highly descriptive ion information from Zeno CID and highly accurate positional confirmation with EAD for glycosylation analysis
  • Enable complete confirmation of expected disulfides and elucidation of scrambled disulfides

 

Featured content

Accelerating the characterization of next generation biotherapeutics with novel ion trapping and alternative fragmentation

Explore new LC-MS methods and approaches to fully characterize and understand risks to some of the most challenging critical quality attributes (CQAs) for these molecules.

Peptide mapping study on human erythropoietin (EPO): a complex N- and O-linked glycoprotein

Discover a streamlined and easy-to-use peptide mapping workflow that makes the most of the incredibly rich MS/MS information from both EAD and CID peptide mapping data

Intuitive software workflow for intact and subunit analysis of monoclonal antibodies (mAbs)

Learn how to get insights for intact and subunit analysis of therapeutic proteins with powerful visualization capabilities

Differentiation of aspartic and isoaspartic acid using electron activated dissociation (EAD)

Leverage EAD to achieve regular and advanced characterization of a biotherapeutic monclonal antibody (mAB) in one injection, accessible to all user levels

Differentiation of leucine and isoleucine using electron activation dissociation (EAD)

Combine routine characterization and elcucidation of challenging residues in one single analysis, without the need for sample specific optimization, to differentiate peptides derived from a mAb therapeutic

Confirmation of disulfide linkages in adalimumab using electron activated dissociation (EAD)

Discover a routine approach for the streamlined characterization of disulfide-linked peptides with a new level of data quality.