mAb charge heterogeneity analysis by CZE Part 2: A case Study from Merck Sharp & Dohme

A case study from MSD in the Netherlands will be presented in which CZE is also optimized and validated. The reasons for choosing the assay will be described, including fast method development, simple workflow, equivalent or better performance than high-performance ion-exchange (HPIEX) and imaged capillary isoelectric focusing (icIEF), as well as standardization on the same capillary electrophoresis (CE) platform as used for CE-SDS analysis (30:57 min)