Unlock reliable and sensitive quantitative biological data with LC-MS solutions that work as hard as you do.
Unlock reliable and sensitive quantitative biological data with LC-MS solutions that work as hard as you do.
Explore the latest and trending topics
Make your bioanalysis effortless when quantifying small and large molecule therapeutic candidates, including cyclic peptides and glucagon-like peptide-1 (GLP-1).
At SCIEX, we are committed to developing LC-MS/MS solutions that streamline and accelerate your bioanalytical assays. Our state-of-the-art hardware and software facilitate rapid quantitation, even for low-abundant ions, ensuring the efficient progression of drug candidates through the pipeline.
Workflow
Gather the precise and reliable data you need to confidently navigate the complexities of cyclic peptide analysis, to advance your next therapeutic.
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Featured resources
Technical note
Sensitive LC-MRMHR approach for cyclic peptide quantitation in human plasma
This technical note demonstrates a reliable and highly sensitive workflow for supporting the quantitative analysis of pasireotide in human plasma.
Technical note
A simple and highly sensitive solution for the quantification of cyclic peptides
Eptifibatide was selected as a model analyte to evaluate the quantitative performance of cyclic peptides on the ZenoTOF 7600 system. Zeno SIM, Zeno CID and Zeno electron activated dissociation (EAD) modes were evaluated for quantification.
Workflow
Breeze through your GLP-1 based analysis in biological matrices with highly sensitive and specific LC-MS systems.
Achieve accurate quantitation even at low concentrations, providing valuable insights into pharmacokinetics and pharmacodynamics.
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Setting a new standard for instrument resilience and robustness, the SCIEX 7500+ system gives you the confidence to face evolving analytical challenges. Tackle tight timelines with exceptional sensitivity and with the power to control your instrument downtime.
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Featured resources
Technical note
Improved LC-MRM workflow for quantification of glucagon like peptide-1 analogues
This technical note describes a robust and sensitive LC-MRM method for the quantification of liraglutide. Excellent sensitivity was achieved in rat plasma with outstanding reproducibility, accuracy, and linearity.
Technical note
Low-ng/mL quantitation of glucagon-like peptide-1 (GLP-1) analog in rat plasma
Discover a sensitive quantitative method for a commercially available GLP-1 analog, semaglutide, in rat plasma. Sensitivity at the low-ng/mL level was achieved in rat plasma using the SCIEX 7500 system.
Technical note
Quantitative performance of a next-generation, highly robust triple quadrupole mass spectrometer
In this technical note we discuss the need for bioanalytical laboratory's need for reliable triple quadrupole mass spectrometers to ensure the delivery of proper quantitative performance and how this need can be met.
Workflow
Gain deep insights into your drug candidate's pharmacokinetics, pharmacodynamics, and overall efficacy with powerful LC-MS solutions from SCIEX.
Your scientists will be able to obtain accurate and reproducible results, advancing drug candidates and ensuring the safety and effectiveness of new therapies.
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Delivering the perfect balance of speed, performance, and sensitivity for your most challenges analytes.
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Featured resources
Technical note
Sensitive and high-throughput quantitation of mezigdomide in rat plasma
Ideal analytical performance: Achieve accurate quantitative performance with %CV <10% at all concentrations across a linear dynamic range (LDR) spanning 4 orders of magnitude.
Technical note
Bioanalysis of β-Lactamase Inhibitors on the SCIEX QTRAP® 6500+ System
Here we discuss a sensitive and accurate LC-MS/MS method for a series of β-lactamase inhibitors extracted from rat plasma by protein precipitation. Linearity within a concentration range of 0.30 to 1000 ng/mL was achieved for sulbactam and tazobactam and within 1.0 to 1000 ng/mL for brobactam.
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Setting a new standard for instrument resilience and robustness, the SCIEX 7500+ system gives you the confidence to face evolving analytical challenges. Tackle tight timelines with exceptional sensitivity and with the power to control your instrument downtime.
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Featured resources
Technical note
Achieve next level sensitivity for the evolution of routine bioanalysis
This technical note describes how sub-pg/mL quantification was achieved for midazolam, imipramine, and clozapine with outstanding reproducibility, precision, accuracy, and linearity.
Technical note
A sensitive method for the quantification of formoterol in human plasma
This technical note presents a sensitive method for the quantification of the highly potent orally inhaled drug, formoterol, in human plasma at concentrations ranging from 0.05 to 100 pg/mL.
Workflow
Easily and confidently analyze large molecules such as proteins, peptides, and monoclonal antibodies to understand their pharmacokinetics, pharmacodynamics, and therapeutic efficacy, even in complex matrices.
Empower your scientists to quantify these compounds providing detailed insights into their behavior and interactions within the body.
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Setting a new standard for instrument resilience and robustness, the SCIEX 7500+ system gives you the confidence to face evolving analytical challenges. Tackle tight timelines with exceptional sensitivity and with the power to control your instrument downtime.
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Featured resources
Technical note
Quantitation of GalNAc modified and unmodified oligonucleotides in rat plasma
Read about how it was possible to quantify oligonucleotides at sub ng/mL in rat plasma.
Technical note
Ultra-sensitive LC-MRM analysis for trastuzumab-emtansine quantification in rat plasma
With the adoption of immunoaffinity based sample preparation, an ultra-low LLOQ of 1 ng/mL was achieved. The assay shows high precision, accuracy, and good linearity, demonstrating the robustness and performance of the developed method.
Hub
Pathways to a new frontier in bioanalysis
Explore innovative bioanalytical solutions to achieve your scientific goals quickly and efficiently.
Technical note
Sensitive LC-MRMHR approach for cyclic peptide quantitation in human plasma
This technical note demonstrates a reliable and highly sensitive workflow for supporting the quantitative analysis of pasireotide in human plasma.
Technical note
A simple and highly sensitive solution for the quantification of cyclic peptides
Eptifibatide was selected as a model analyte to evaluate the quantitative performance of cyclic peptides on the ZenoTOF 7600 system. Zeno SIM, Zeno CID and Zeno electron activated...
Technical note
Improved LC-MRM workflow for quantification of glucagon like peptide-1 analogues
This technical note describes a robust and sensitive LC-MRM method for the quantification of liraglutide. Excellent sensitivity was achieved in rat plasma with outstanding reproducibility, accuracy, and linearity.
Technical note
Low-ng/mL quantitation of glucagon-like peptide-1 (GLP-1) analog in rat plasma
Discover a sensitive quantitative method for a commercially available GLP-1 analog, semaglutide, in rat plasma. Sensitivity at the low-ng/mL level was achieved in rat plasma using the SCIEX 7500 system.
Technical note
Quantitative performance of a next-generation, highly robust triple quadrupole mass spectrometer
In this technical note we discuss the need for bioanalytical laboratory's need for reliable triple quadrupole mass spectrometers to ensure the delivery of proper quantitative performance and how this need can be met.
Technical note
Sensitive and high-throughput quantitation of mezigdomide in rat plasma
Ideal analytical performance: Achieve accurate quantitative performance with %CV <10% at all concentrations across a linear dynamic range (LDR) spanning 4 orders of magnitude.
Technical note
Bioanalysis of β-Lactamase Inhibitors on the SCIEX QTRAP® 6500+ System
Here we discuss a sensitive and accurate LC-MS/MS method for a series of β-lactamase inhibitors extracted from rat plasma by protein precipitation. Linearity within a...
Technical note
Achieve next level sensitivity for the evolution of routine bioanalysis
This technical note describes how sub-pg/mL quantification was achieved for midazolam, imipramine, and clozapine with outstanding reproducibility, precision, accuracy, and linearity.
Technical note
A sensitive method for the quantification of formoterol in human plasma
This technical note presents a sensitive method for the quantification of the highly potent orally inhaled drug, formoterol, in human plasma at concentrations ranging from 0.05 to...
Technical note
Accurate identification and robust quantification of intact and subunits of monoclonal antibodies (mAb) using LC-UV-MS
Technical note Accurate identification and robust quantification of intact and subunits of monoclonal antibodies (mAb) using LC-UV-MS Here, subunits of a mAb sample and an intact mAb spiked with different levels of protein impurities were used to investigate automatic identification and relative quantification with an LC-UV-MS workflow, using Biologics Explorer software.
Technical note
Quantitation of GalNAc modified and unmodified oligonucleotides in rat plasma
Read about how it was possible to quantify oligonucleotides at sub ng/mL in rat plasma.
Technical note
Ultra-sensitive LC-MRM analysis for trastuzumab-emtansine quantification in rat plasma
With the adoption of immunoaffinity based sample preparation, an ultra-low LLOQ of 1 ng/mL was achieved. The assay shows high precision, accuracy, and good linearity, demonstrating the robustness and performance of the developed method.
Explore the potential of trusted LC-MS/MS solutions designed to simplify and accelerate biomarker quantitation. Bring drug candidates through the development pipeline more efficiently and confidently with accurate results obtained using innovative hardware and software, lab-tested methods and expert support.
Advance the development of your next therapeutic drug with easy-to-operate, integrated analytical systems that can provide new insights into ADME-Tox and DMPK. Rapidly and comprehensively characterize drug candidates with robust and sensitive solutions for identification, monitoring and quantitation.
Advance your drug discoveries with reliable metabolite data that save time and money. Our range of solutions supports routine monitoring and complex identification to give your team confidence during synthetic therapeutic development.
Easily advance your targeted protein degraders and proteolysis targeting chimeras (PROTACs) with reliable and sensitive analytical data. Give your team the confidence to develop synthetic therapeutics with the support of the SCIEX technical team.