Quantitative bioanalysis

Pathways to a new frontier in bioanalysis

Explore innovative bioanalytical solutions to achieve your scientific goals quickly and efficiently.

Sensitive LC-MRMHR approach for cyclic peptide quantitation in human plasma

This technical note demonstrates a reliable and highly sensitive workflow for supporting the quantitative analysis of pasireotide in human plasma.

A simple and highly sensitive solution for the quantification of cyclic peptides

Eptifibatide was selected as a model analyte to evaluate the quantitative performance of cyclic peptides on the ZenoTOF 7600 system. Zeno SIM, Zeno CID and Zeno electron activated...

Improved LC-MRM workflow for quantification of glucagon like peptide-1 analogues

This technical note describes a robust and sensitive LC-MRM method for the quantification of liraglutide. Excellent sensitivity was achieved in rat plasma with outstanding reproducibility, accuracy, and linearity.

Low-ng/mL quantitation of glucagon-like peptide-1 (GLP-1) analog in rat plasma

Discover a sensitive quantitative method for a commercially available GLP-1 analog, semaglutide, in rat plasma. Sensitivity at the low-ng/mL level was achieved in rat plasma using the SCIEX 7500 system.

Quantitative performance of a next-generation, highly robust triple quadrupole mass spectrometer

In this technical note we discuss the need for bioanalytical laboratory's need for reliable triple quadrupole mass spectrometers to ensure the delivery of proper quantitative performance and how this need can be met.

Sensitive and high-throughput quantitation of mezigdomide in rat plasma

Ideal analytical performance: Achieve accurate quantitative performance with %CV <10% at all concentrations across a linear dynamic range (LDR) spanning 4 orders of magnitude.

Bioanalysis of β-Lactamase Inhibitors on the SCIEX QTRAP® 6500+ System

Here we discuss a sensitive and accurate LC-MS/MS method for a series of β-lactamase inhibitors extracted from rat plasma by protein precipitation. Linearity within a...

Achieve next level sensitivity for the evolution of routine bioanalysis

This technical note describes how sub-pg/mL quantification was achieved for midazolam, imipramine, and clozapine with outstanding reproducibility, precision, accuracy, and linearity.

A sensitive method for the quantification of formoterol in human plasma

This technical note presents a sensitive method for the quantification of the highly potent orally inhaled drug, formoterol, in human plasma at concentrations ranging from 0.05 to...

Accurate identification and robust quantification of intact and subunits of monoclonal antibodies (mAb) using LC-UV-MS

Technical note Accurate identification and robust quantification of intact and subunits of monoclonal antibodies (mAb) using LC-UV-MS Here, subunits of a mAb sample and an intact mAb spiked with different levels of protein impurities were used to investigate automatic identification and relative quantification with an LC-UV-MS workflow, using Biologics Explorer software.

Quantitation of GalNAc modified and unmodified oligonucleotides in rat plasma

Read about how it was possible to quantify oligonucleotides at sub ng/mL in rat plasma.

Ultra-sensitive LC-MRM analysis for trastuzumab-emtansine quantification in rat plasma

With the adoption of immunoaffinity based sample preparation, an ultra-low LLOQ of 1 ng/mL was achieved. The assay shows high precision, accuracy, and good linearity, demonstrating the robustness and performance of the developed method.

Maintain excellent quantitative performance for bioanalytical workflows on a high-resolution mass spectrometer (HRMS)

This technical note highlights a sensitive and reliable method for quantifying moxifloxacin in human plasma using the ZenoTOF 7600 system. Leveraging the Zeno MRMHR workflow, the method delivers consistent performance across runs, offering a powerful alternative to traditional triple quadrupole platforms for accurate, high-resolution bioanalysis in complex matrices.

Development of a sensitive LC-MS/MS method for quantitation of trastuzumab emtansine in human serum

Discover a highly sensitive method for quantifying trastuzumab emtansine (TEx) in human serum using the SCIEX 7500+ system. Achieving an impressive LLOQ of 0.025 µg/mL and LOD of 0.0125 µg/mL, this approach demonstrates robust performance in extracted serum samples.