Advance the development of your next therapeutic drug with easy-to-operate, integrated analytical systems that can provide new insights into ADME and DMPK. Rapidly and comprehensively characterize drug candidates with robust and sensitive solutions for identification, monitoring and quantitation.
ADME-Tox and DMPK
Overview
Confidently complete your ADME-Tox and DMPK studies across all drug development phases with dependable instruments run on intuitive, compliant-ready software. Fit-for-purpose LC-MS solutions enable pharmacokinetic parameter monitoring in complex matrices with excellent sensitivity and robustness, even for low-dose, highly potent drugs.
ADME-Tox studies
Workflow
Breeze through your routine ADME-Tox studies using highly sensitive and robust LC-MS solutions that have been designed to meet your team’s needs. Simplify monitoring of ADME-Tox parameters, even for highly potent drug substances in complex matrices, with compliant-ready SCIEX OS software.
- Perform ADME-Tox studies with confidence using compliant-ready software
- Achieve reliable and sensitive bioanalytical data using fit-for-purpose LC-MS solutions
ADME-Tox studies
Suited for:
- Regulated and non-regulated ADME-Tox studies at any phase
- Assays needing additional sensitivity
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Learn more
SCIEX Triple Quad 6500+ system
Delivering the perfect balance of speed, performance, and sensitivity for your most challenges analytes.
Learn more
SCIEX OS software
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Learn more
Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Learn more
SCIEX 7500 system
Detect the previously undetectable and quantify at lower levels than ever before with impressive precision.
Learn more
SCIEX OS software
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Learn more
Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
Featured resources
-
Technical note
A sensitive method for the quantitative of formoterol in human plasma
Discover a sensitive method for the quantitation of the highly potent orally inhaled drug, formoterol, in human plasma. Highly reproducible performance was achieved with linearity demonstrated at concentrations ranging from 0.05 to 100 pg/mL.
-
Technical note
Pharmacologically relevant measurement of high potency drug candidates with improved sensitivity in in-vitro transporter assays
Discover how the SCIEX 7500 system provides the high-quality data needed to improve compound rank ordering and selection in early-stage drug development.
DMPK and Bioanalysis studies
Workflow
Achieve robust DMPK and bioanalytical data with access to a range of integrated solutions that deliver reliable and trustworthy performance, even for highly potent and low-abundance compounds in complex matrices. Help ensure collection of reliable data using compliant-ready software backed by a team of technical experts ready to support your need
- Achieve robust and sensitive performance, even for low-abundant compounds
- Gain access to a trusted team of technical experts
- Compliant-ready software
DMPK and Bioanalysis studies
Suited for:
- Absolute sensitivity and quantitation
- Demanding robustness
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Learn more
SCIEX 7500 system
Detect the previously undetectable and quantify at lower levels than ever before with impressive precision.
Learn more
SCIEX OS software
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Learn more
Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
Featured resources
-
Technical note
A sensitive method for the quantitation of formoterol in human plasma
See how a simple liquid-liquid extraction sample preparation protocol is used for accurate, reproducible, low-level (0.05 pg/mL) quantification of formoterol in human plasma.
-
Technical note
Robustness of the SCIEX 7500 system for small molecule analysis in tissue
Learn more about the potential for high levels of robustness and repeatability in bioanalysis, demonstrated with two challenging samples and using 4,000 continuous injections of a rat liver homogenate.
-
Technical note
Quantifying fluticasone propionate and salmeterol xinafoate with high sensitivity in human plasma
Review a highly sensitive, rapid LC-MS/MS method for simultaneous quantitation of two highly potent, low-dose inhalants in human plasma, with LLOQs in the 0.05 pg/mL range using 400 μL of plasma.
DMPK and Bioanalysis studies
Suited for:
- Analytical flexibility allowing quan/qual work
- Bioanalyses requiring additional selectivity or a high mass range
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Learn more
ZenoTOF 7600 system
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
Learn more
SCIEX OS software
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Learn more
Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
All resources
-
Technical note
A sensitive method for the quantification of formoterol in human plasma
See how a simple liquid-liquid extraction sample preparation protocol is used for accurate, reproducible, low-level (0.05 pg/mL) quantification of formoterol in human plasma.
-
Technical note
Robustness of the SCIEX 7500 system for small molecule analysis in tissue
Learn more about the potential for high levels of robustness and repeatability in bioanalysis, demonstrated with two challenging samples and using 4,000 continuous injections of a rat liver homogenate.
-
Technical note
Quantifying fluticasone propionate and salmeterol xinafoate with high sensitivity in human plasma
Review a highly sensitive, rapid LC-MS/MS method for simultaneous quantitation of two highly potent, low-dose inhalants in human plasma, with LLOQs in the 0.05 pg/mL range using 400 μL of plasma.
-
Technical note
Highly sensitive LC-MS/MS method for the quantification of fluticasone propionate in human plasma
Observe a selective, sensitive and reproducible bioanalytical method for quantitation of fluticasone propionate in human plasma with a sub-picogram level LLOQ that is suitable for use in regulated bioanalytical laborator.
-
Technical note
A sensitive method for the quantitation of formoterol in human plasma
See how a simple liquid-liquid extraction sample preparation protocol is used for accurate, reproducible, low-level (0.05 pg/mL) quantification of formoterol in human plasma.
-
Technical note
Pharmacologically relevant measurement of high potency drug candidates with improved sensitivity in in-vitro transporter assays
Discover how the SCIEX 7500 System provides the higher quality data needed to improve compound rank ordering and selection in early-stage drug development.
-
Technical note
Confident identification of phase 1 metabolites using electron-activated dissociation (EAD)
Uncover how an orthogonal fragmentation technique provides complementary MS/MS spectral data, allowing rapid, software-aided characterization and identification of low-level metabolites in support of drug metabolism studies.
Associated applications
High-throughput mass spectrometry
Screen thousands of candidates for desirable drug properties and process data with confidence faster than ever before. Get the information you need to make go/no-go decisions as quickly as possible in the drug discovery phase of your work.
Learn more