Breeze through routine ADME-Tox studies, even for highly potent drug substances in complex matrices.
ADME-Tox and DMPK
Overview
Get tried and tested performances, time and time again, even for low-abundant compounds, with robust and sensitive SCIEX solutions on your side. Advance the development of your next therapeutic drug with easy-to-operate, integrated analytical systems that can provide new insights into ADME-Tox and DMPK. Rapidly quantify drug candidates with robust, sensitive solutions, all supported by trusted service.
ADME-Tox studies
Workflow
Breeze through your routine ADME-Tox studies using highly sensitive and robust LC-MS solutions that have been designed to meet your team’s needs. Simplify monitoring of ADME-Tox parameters, even for highly potent drug substances in complex matrices, with compliant-ready SCIEX OS software.
- Conduct ADME-Tox and DMPK studies with confidence, using compliance-ready software to ease the process.
- Unlock reliable and sensitive bioanalytical data with LC-MS solutions that work as hard as you do.
- Always have expert support on hand with dependable service at your fingertips.
- Streamlined audit preparation with compliance-ready software.
ADME-Tox studies
Suited for:
- Regulated and non-regulated ADME-Tox studies at any phase
- Assays needing additional sensitivity
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Learn more
SCIEX Triple Quad 6500+ system
Delivering the perfect balance of speed, performance, and sensitivity for your most challenges analytes.
Learn more
SCIEX OS software
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Learn more
Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Learn more
SCIEX 7500+ Triple Quad system – QTRAP ready
Setting a new standard for instrument resilience and robustness, the SCIEX 7500+ system gives you the confidence to face evolving analytical challenges. Tackle tight timelines with exceptional sensitivity and with the power to control your instrument downtime.
Learn more
SCIEX OS software
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Learn more
Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
DMPK and Bioanalysis studies
Workflow
Achieve robust DMPK and bioanalytical data with access to a range of integrated solutions that deliver reliable and trustworthy performance, even for highly potent and low-abundance compounds in complex matrices. Help ensure collection of reliable data using compliant-ready software backed by a team of technical experts ready to support your need
- Get tried and tested performances, time and time again, even with low-abundant compounds.
- Always have expert support on hand with dependable service at your fingertips.
- Streamlined audit preparation with compliance-ready software.
DMPK and Bioanalysis studies
Suited for:
- Absolute sensitivity and quantitation
- Demanding robustness
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Learn more
SCIEX 7500+ Triple Quad system – QTRAP ready
Setting a new standard for instrument resilience and robustness, the SCIEX 7500+ system gives you the confidence to face evolving analytical challenges. Tackle tight timelines with exceptional sensitivity and with the power to control your instrument downtime.
Learn more
SCIEX OS software
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Learn more
Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
Featured resources
-
Technical note
Combining mass spectral data analysis and endpoint calculations for drug discovery insights
This technical note introduces an innovative software solution designed to combine mass spectral analysis and endpoint calculations, delivering quick and accurate quantitative results to support drug discovery.
-
Technical note
Combining mass spectral data analysis and endpoint calculations for drug discovery insights
This technical note introduces an innovative software solution designed to combine mass spectral analysis and endpoint calculations, delivering quick and accurate quantitative results to support drug discovery.
DMPK and Bioanalysis studies
Suited for:
- Analytical flexibility allowing quan/qual work
- Bioanalyses requiring additional selectivity or a high mass range
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
Learn more
ZenoTOF 7600 system
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
Learn more
SCIEX OS software
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Learn more
Service
Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.
Learn more
Featured resources
-
Technical note
Confident identification of phase 1 metabolites using electron-activated dissociation (EAD)
Uncover how an orthogonal fragmentation technique provides complementary MS/MS spectral data, allowing rapid, software-aided characterization and identification of low-level metabolites in support of drug metabolism studies.
-
Technical note
Fast and sensitive method for quantitation of lenalidomide in human plasma
Read more about how it was possible to establish a robust quantitative method for the detection of lenalidomide with a run time of just 2.5 mins, while using minimal amounts of sample.
-
Technical note
Reducing high resolution mass spectral data complexity for quick and accurate insights
This technical note introduces an innovative software solution designed to simplify the complexities of high-resolution mass spectra, delivering quick and accurate quantitative results.
All resources
-
Technical note
Robustness of the SCIEX 7500 system for small molecule analysis in tissue
Learn more about the potential for high levels of robustness and repeatability in bioanalysis, demonstrated with two challenging samples and using 4,000 continuous injections of a rat liver homogenate.
-
Technical note
Pharmacologically relevant measurement of high potency drug candidates with improved sensitivity in in-vitro transporter assays
Discover how the SCIEX 7500 System provides the higher quality data needed to improve compound rank ordering and selection in early-stage drug development.
-
Technical note
Confident identification of phase 1 metabolites using electron-activated dissociation (EAD)
Uncover how an orthogonal fragmentation technique provides complementary MS/MS spectral data, allowing rapid, software-aided characterization and identification of low-level metabolites in support of drug metabolism studies.
-
Technical note
Fast and sensitive method for quantitation of lenalidomide in human plasma
Read more about how it was possible to establish a robust quantitative method for the detection of lenalidomide with a run time of just 2.5 mins, while using minimal amounts of sample.
-
Technical note
Combining mass spectral data analysis and endpoint calculations for drug discovery insights
This technical note introduces an innovative software solution designed to combine mass spectral analysis and endpoint calculations, delivering quick and accurate quantitative results to support drug discovery.
Associated applications
High-throughput mass spectrometry
Screen thousands of candidates for desirable drug properties and process data with confidence faster than ever before. Get the information you need to make go/no-go decisions as quickly as possible in the drug discovery phase of your work.
Learn more
Metabolite Identification
Advance your drug discoveries with reliable metabolite data that save time and money. Our range of solutions supports routine monitoring and complex identification to give your team confidence during synthetic therapeutic development.
Synthetic oligonucleotide analysis
Work in pursuit of a higher level of quality for characterization of synthetic oligonucleotides—such as single guide RNA (sgRNA) or prime editing guide RNA (pegRNA)—used for CRISPR/Cas9 gene editing applications, along with antisense oligonucleotides (ASOs), small interfering RNA (siRNA) and aptamer therapeutics.
Oligonucleotide analysis
Break through the boundaries of characterizing synthetic oligonucleotides—such as antisense oligonucleotides (ASOs), small interfering RNA (siRNA) and single guide RNA (sgRNA)—along with plasmids, DNA and more. Discover intuitive solutions that let you set your own schedule and optimize your workflows for what matters for your nucleic acid products.
Protein Therapeutics
Tackle the next frontier in protein therapeutics with analytical strategies ignited by collaboration.