AB Sciex is doing business as SCIEX. © 2010-2019 AB Sciex. The trademarks mentioned herein are the property of the AB Sciex Pte. Ltd. or their respective owners. AB SCIEX™ is being used under license. Beckman Coulter® is being used under license. Product(s) may not be available in all countries. For information on availability, please contact your local representative. For research use only. Not for use in diagnostic procedures.

Triple Quad 6500+ System

SCIEX Triple Quad™ 6500+ LC-MS/MS System

Revolutionary Sensitivity, Speed, and Performance with IonDrive™ Technology

The Triple Quad 6500+ LC-MS/MS system features multi-component IonDrive Technology including the IonDrive High Energy Detector+ that pushes the boundaries of LC-MS/MS quantitation farther than ever before. The revolutionary sensitivity, speed, and performance delivered through these technology enhancements enable you to see it all, from low mass to high mass compounds, in positive or negative polarity – in a single injection, with high sensitivity, reliability, and confidence.

  • Superior signal-to-noise and LOQ for the widest scope of chemical compounds in the most challenging matrices
  • Up to 6 orders of linear dynamic range for enhanced breadth of applications
  • Increased throughput with polarity switching speeds of 5 msec
  • No compromise in mass range with a 2000 m/z upper mass limit
  • Scan speeds of up to 12,000 Da/second for optimized UHPLC strategies
  • Compatible with SelexION®+ differential ion mobility
  • Enhanced ion transmission for added selectivity without compromising LOQs

The Triple Quad 6500+ system delivers revolutionary sensitivity, speed, and performance for your most challenging methods.

Status: Available

More Ions with IonDrive Technology

Key Features

Mass Range 5-2000 Da
Features IonDrive QJet, HED Detector
Detector Type IonDrive High Energy Detector+
Scan Types Q1 MS, Q3 MS, Product Ion, Precursor Ion, Neutral Loss or Gain, MRM, EMS, EPI, ER, MS3, MRM3
Ionization Sources/Options IonDrive Turbo V; OptiFlow™ Turbo V; TurboIonSpray®; Atmospheric-pressure chemical ionization (APCI); DuoSpray™, and NanoSpray® III, Phytronix LDTD, Advion LESA Clarity, Digital PicoView, NanoSource, SelexION®+

Downloads & Resources

Resources

Software

Chemical Standards

Part NumberKit Name/InstrumentDescription
4406127 MS Chemical Kit 1, Low-High Conc. PPGs

Standards chemical kit with low/high concentrations of polypropylene glycol polymers (PPGs).
This kit includes all solutions necessary for installation and calibration for all SCIEX Triple Quads, excluding the API 2000™ and API 3000™ instruments.
4412399 MS Chemical Kit2, Higher Conc. PPGs

Standards chemical kit with High Concentrations PPGs.
This kit includes all solutions necessary for installation and calibration for all API 2000 and 3000 instruments.
4465788 SelexION® Calibration Solution

Installation and Calibration Solution for SelexION Ion Mobility Source.
5056819 Essential LCMS Performance Kit Environmental

Certified QC kits for use on SCIEX Triple Quad and QTRAP® 4500, 5500, 6500 and 6500+ systems, coupled with high flow LC systems, to test performance in both positive and negative modes for Environmental applications.
5056822 Essential LCMS Performance Kit Toxicology

Certified QC kits for use on SCIEX Triple Quad and QTRAP 4500, 5500, 6500 and 6500+ systems, coupled with high flow LC systems, to test performance in both positive and negative modes for Toxicology applications.
5056816 Essential LCMS Performance Kit Small Molecule Pharma

Certified QC kits for use on SCIEX Triple Quad and QTRAP 4500, 5500, 6500 and 6500+ systems, coupled with high flow LC systems, to test performance in both positive and negative modes for Pharma (Small Molecule) applications.
5056815 Essential LCMS Performance Kit - Peptide

Certified QC kits for use on SCIEX Triple Quad and QTRAP 4500, 5500, 6500 and 6500+ systems, coupled with high flow LC systems, to test performance in positive mode for Peptide applications.

RUO-MKT-18-2502-D

triple-quad-6500plus-image-callout
1. Mass Range

Triple quadrupole: 5 – 2,000 Da

2. Flexible Ionization Options

Options include OptiFlow Turbo V™ Electrospray (ESI) ionization and heated nebulizer ionization probes.

Triple Quad 6500+ System
1
2
3
4
5
3. Selective, Robust and Powerful Ion Separation

Optional SelexION®+

4. Detector Type

IonDrive™ High Energy Detector+

5. Polarity Switching

5 msec in MRM and Scheduled MRM™ modes

triple-quad-6500plus-intro-icontop-4col

Enhancements for the 6500+ Series

The production of more ions with the IonDrive™ Turbo V source is just one of the enhancements you will see with the Triple Quad 6500+. Also added is the ability to capture and transmit more ions with the unique IonDrive™ QJet guide and greater detection with the new IonDrive™ High Energy Detector+.

IonDrive™ Turbo V Source

IonDrive Turbo V Source

The legendary Turbo V™ source increases ion production by using enhanced gas flow dynamics and optimized heater configuration to improve reliability, reproducibility, and robustness.

Learn More
IonDrive™ QJet Guide

IonDrive QJet Guide

With its dual stage design, the IonDrive QJet Guide improves sensitivity and ion capture rate while focusing ions more efficiently than funnel approaches.

Learn More
IonDrive™ High Energy Detector+

IonDrive High Energy Detector+

Pulse counting fundamentals achieve ultra sensitivity at the lower end, while increasing linearity at high count rates. The result is the collection of more ions across a broader dynamic range.

Learn More
SelexION®+ DMS Technology

SelexION®+ DMS Technology

Ideal development suite for applications requiring the separation of isobaric species, isolation of challenging co-eluting contaminants, and reduction of high background noise.

Learn More
Resources
Filter by Type:

Title Date
Potency Analysis in Hemp and Cannabis Products 07/25/2019
Direct Sample Analysis Using TEIS Combined with Mass Spectrometry 06/29/2019
Quantitative LC-MS Solution for Targeted Analysis of Cell Culture Media 06/12/2019
AN-Hydrophilic Marine Biotoxins in Seafood 06/12/2019
Analysis of the Canadian Cannabis Pesticides List Using Both ESI and APCI Techniques 06/06/2019
User Guide: NanoSpray Ion Source Operator Guide (EN) 04/17/2019
Sub-Picogram Level Quantitation of Desmopressin in Small Volumes of Human Plasma Using a Trap-Elute MicroLC-MS System 04/17/2019
IonDrive Turbo V Ion Source Operator Guide (EN) 04/01/2019
IonDrive Turbo V Ion Source Operator Guide (FR) 04/01/2019
IonDrive Turbo V Ion Source Operator Guide (DE) 04/01/2019
IonDrive Turbo V Ion Source Operator Guide (IT) 04/01/2019
IonDrive Turbo V Ion Source Operator Guide (ES) 04/01/2019
IonDrive Turbo V Ion Source Operator Guide (JA) 04/01/2019
IonDrive Turbo V Ion Source Operator Guide (ZH) 04/01/2019
6500 and 6500+ Series of Instruments Qualified Maintenance Person Guide (EN) 03/01/2019
Ion Source Tests, Specifications, and Data Log (EN) 03/01/2019
6500 and 6500+ Series of Instruments Qualified Maintenance Person Guide (DE) 03/01/2019
6500 and 6500+ Series of Instruments Qualified Maintenance Person Guide (FR) 03/01/2019
6500 and 6500+ Series of Instruments Qualified Maintenance Person Guide (IT) 03/01/2019
6500 and 6500+ Series of Instruments Qualified Maintenance Person Guide (ES) 03/01/2019
6500 and 6500+ Series of Instruments Qualified Maintenance Person Guide (JA) 03/01/2019
6500 and 6500+ Series of Instruments Qualified Maintenance Person Guide (ZH) 03/01/2019
OptiFlow Turbo V Ion Source Operator Guide (EN) 03/01/2019
OptiFlow Turbo V Ion Source Operator Guide (DE) 03/01/2019
OptiFlow Turbo V Ion Source Operator Guide (ES) 03/01/2019
OptiFlow Turbo V Ion Source Operator Guide (FR) 03/01/2019
OptiFlow Turbo V Ion Source Operator Guide (IT) 03/01/2019
OptiFlow Turbo V Ion Source Operator Guide (JA) 03/01/2019
OptiFlow Turbo V Ion Source Operator Guide (ZH) 03/01/2019
Ion Source Tests, Specifications, and Data Log (ZH) 03/01/2019
Ion Source Tests, Specifications, and Data Log (IT) 03/01/2019
Ion Source Tests, Specifications, and Data Log (JA) 03/01/2019
Ion Source Tests, Specifications, and Data Log (ES) 03/01/2019
Ion Source Tests, Specifications, and Data Log (FR) 03/01/2019
Ion Source Tests, Specifications, and Data Log (DE) 03/01/2019
SCIEX 6500+ Series Mass Spectrometers - KR 01/22/2019
Extending the Lower Limits of Quantification of a Therapeutic Oligonucleotide Through Microflow LC-MSMS 01/22/2019
SelexION/SelexION+ Technology User Guide for SCIEX Triple Quad and QTRAP Systems (ZH) 01/15/2019
SelexION/SelexION+ Technology Site Planning Guide for SCIEX Triple Quad and QTRAP Systems (ZH) 12/19/2018
Turbo V Ion Source Operator Guide (IT) 12/01/2018
Turbo V Ion Source Operator Guide (DE) 12/01/2018
Turbo V Ion Source Operator Guide (FR) 12/01/2018
Turbo V Ion Source Operator Guide (ES) 12/01/2018
Turbo V Ion Source Operator Guide (EN) 12/01/2018
Turbo V Ion Source Operator Guide (PT) 12/01/2018
Turbo V Ion Source Operator Guide (RU) 12/01/2018
Turbo V Ion Source Operator Guide (ZH) 12/01/2018
Turbo V Ion Source Operator Guide (JA) 12/01/2018
Turbo V Ion Source Operator Guide (PL) 12/01/2018
Brochure KR: Triple Quad and QTRAP 6500+ 11/28/2018
Ultra-Sensitive Quantification of Trastuzumab Emtansine in Mouse Plasma using Trap-Elute MicroLC-MS Method 08/10/2018
Universal Solution for Monoclonal Antibody Quantification of Biological Fluids Using Trap Elute MicroLC-MS Method 08/10/2018
Method Development 101-How Easy Can Implementation Be 05/15/2018
SCIEX QTRAP 6500+ and SCIEX Triple QUAD 6500+ Declaration of Conformance 12/22/2017
6500+ Series of Instruments Site Planning Guide (North America/EMEA only) 12/20/2017
6500 and 6500+ Series of Instruments Site Planning Guide (FR) 12/20/2017
6500 and 6500+ Series of Instruments Site Planning Guide (IT) 12/20/2017
6500 and 6500+ Series of Instruments Site Planning Guide (ES) 12/20/2017
6500 and 6500+ Series of Instruments System User Guide (ES) 12/20/2017
6500 and 6500+ Series of Instruments System User Guide (FR) 12/20/2017
6500 and 6500+ Series of Instruments System User Guide (IT) 12/20/2017
DuoSpray Ion Source for Triple Quadrupole and QTRAP Systems Operator Guide (IT) 12/20/2017
6500 and 6500+ Series of Instruments System User Guide (DE) 12/01/2017
DuoSpray Ion Source for Triple Quadrupole and QTRAP Systems Operator Guide (DE) 10/10/2017
DuoSpray Ion Source for Triple Quadrupole and QTRAP Systems Operator Guide 10/01/2017
6500+ Series of Instruments Site Planning Guide (DE) 10/01/2017
Rapid LC-MS-MS Method for the Analysis of Fipronil and Amitraz Insecticides 09/20/2017
Analysis of Estrogens and their Methoxy- and Hydroxy-Metabolites in Serum using the SCIEX Triple Quad™ 6500+ LC-MS/MS System 05/01/2017
Novel Method for the Unambiguous Measurement of Low-Level Testosterone in Human Serum using Differential Ion Mobility Spectrometry-Tandem Mass Spectrometry (DMS-MS/MS) 08/25/2016
Ultra-Sensitive Analysis of Aldosterone in Serum by HPLC-MS/MS 08/25/2016
User Guide: 3500, 4500, and 6500+ Systems Electromagnetic Environment Information 04/20/2016
Introducing the SCIEX Triple Quad and QTRAP 6500+ LC-MS/MS System with optional SelexION Technology 10/01/2015
LC-MS/MS Analysis of Emerging Food Contaminants (6500+) 10/01/2015
LC-MS/MS Analysis of Emerging Food Contaminants (Perfluoroalkyl Acids) 10/01/2015
User Guide: PhotoSpray Ion Source Operator Guide 09/16/2015
6500 and 6500+ Series of Instruments System User Guide 09/11/2015
User Guide: DuoSpray Ion Source for Triple Quadrupole and QTRAP Systems Operator Guide (IT) 08/31/2015
User Guide: DuoSpray Ion Source for Triple Quadrupole and QTRAP Systems Operator Guide (FR) 08/31/2015
User Guide: DuoSpray Ion Source for Triple Quadrupole and QTRAP Systems Operator Guide (ES) 08/31/2015
User Guide: PhotoSpray Ion Source Operator Guide (DE) 08/31/2015
User Guide: PhotoSpray Ion Source Operator Guide (IT) 08/31/2015
User Guide: PhotoSpray Ion Source Operator Guide (FR) 08/31/2015
User Guide: PhotoSpray Ion Source Operator Guide (ES) 08/31/2015
6500+ Brochure (Triple Quad and QTRAP) 08/03/2015
User Guide: 6500 and 6500+ Series of Instruments Site Planning Guide 06/30/2015
Instrument Front-End Cleaning Procedure Manual 10/01/2013
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AB Sciex is doing business as SCIEX. © 2010-2019 AB Sciex. The trademarks mentioned herein are the property of the AB Sciex Pte. Ltd. or their respective owners. AB SCIEX™ is being used under license. Beckman Coulter® is being used under license. Product(s) may not be available in all countries. For information on availability, please contact your local representative. For research use only. Not for use in diagnostic procedures.