AB Sciex is doing business as SCIEX. © 2010-2019 AB Sciex. The trademarks mentioned herein are the property of the AB Sciex Pte. Ltd. or their respective owners. AB SCIEX™ is being used under license. Beckman Coulter® is being used under license. Product(s) may not be available in all countries. For information on availability, please contact your local representative. For research use only. Not for use in diagnostic procedures.

CESI 8000 Plus ESI-MS-High-Performance System

For research use only. Not for use in diagnostic procedures.

The perfect accessory for your Mass Spectrometer

CESI: The integration of Capillary Electrophoresis (CE) with Electrospray Ionization (ESI) into a single dynamic process within the same device.

The result:

  • Increased sensitivity and reduced ion suppression
  • Expanded information from as little as 1 µL starting material
  • High-resolution separation of polar and charged analytes
  • In-depth characterization of proteoforms, protein complexes, and critical PTMs

For analysis in areas such as:

Check out our webinars, videos, brochures, tech notes and manuals.

Watch the 2016 Inaugural CESI-MS Symposium Webinar's on Demand

To find out how CESI-MS can help you, request your samples to be analyzed now.

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CESI 8000 Plus ESI-MS System

See What You've Been Missing with CESI-MS

Experience the revolutionary ESI-MS approach to discovering previously undetectable characteristics from the minutest amount of precious samples, faster than ever before. Whether using as a standalone capillary electrophoresis instrument or in conjunction with the power of mass spectrometry, the CESI 8000 Plus allows you to concentrate on your science rather than technology. You’ve worked hard to get your sample this far. Get the most from that precious material and hunt down the hidden information you couldn’t see before:

  • Intact mAb charge variants with online MS detection
  • Proteoforms & peptide PTMs such as those with multiple phosphorylation sites
  • Challenging charged & polar metabolites/degradation products such as anionic and/or hydrophilic analytes
  • Isobaric metabolites and glycans not resolved by traditional techniques
  • Protein conformation and quantitation

The Ultimate Tool for High-Resolution Biotherapeutics Separations

Downloads & Resources

RUO-MKT-18-5206-F

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Go Beyond the Possibilities

The CESI 8000 Plus high-performance system delivers fast, efficient and unique separation selectivity with enhanced sensitivity, while simultaneously expanding coverage.

CE-MS: More Info, Less Sample

Learn why capillary electrophoresis - mass spectrometry (CE-MS) is an attractive microscale analytical technique for addressing biological questions inherently dealing with low amounts of material.

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SWATH® Acquisition

Isobaric Compounds

Simplify the analysis of isobaric compounds inadequately resolved with current methods.

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Native

Native Conditions

Study the molecular interactions and structure of your proteins and peptides under native conditions.

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CESI 8000_3col2

See More Than Ever Before

Expaned coverage allows you to see more than ever before.

Expand the Coverage

Reveal hydrophilic charged and polar compounds and increase sensitivity in your metabolome and glycome analysis, not possible with LC methods.

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SWATH® Acquisition

Uncover New PTMs

Confidently quantify and characterize proteoform and peptide PTMs, such as those with multiple phosphorylation and glycosylation sites.

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SelexION Technology

Separate Isomers

Resolve isomers – unseeable with traditional LC-MS methods.

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Resources
Filter by Type:

Title Date
Comprehensive Capillary Electrophoresis Training Course 07/26/2019
Better Insights into Charge Variants of Therapeutic IgGs 06/21/2019
Neutral CESI Electrical Conditioning 06/17/2019
Neutral CESI Peptide Separation 06/17/2019
Neutral CESI Protein Separation 06/17/2019
Neutral CESI Rest 06/17/2019
Neutral CESI Washing 06/17/2019
Charge Heterogeneity Analysis of Intact Infliximab Using CESI-MS and Neutral OptiMS Cartridge 05/31/2019
Windows10 Announcement 03/20/2019
CESI 8000 Plus High Performance Separation-ESI Module Software Validation Summary 03/20/2019
CESI 8000 Plus High Performance Separation-ESI Module User Manual 03/18/2019
CESI 8000 Plus High Performance Separation-ESI Module System Administration Guide 03/18/2019
OptiMS Silica Surface Cartridge Quick Start Guide 03/18/2019
Neutral OptiMS Cartridge Quick Start Guide 01/15/2019
Environmental Compendium Volume 3 12/10/2018
CESI-MS/MS: Quantitation of Highly Polar Pesticides 12/07/2018
Charge Variant Assessment of Nanobodies at the Intact Level by CESI-MS 10/24/2018
Resolving volume-restricted metabolomics using capillary electrophoresis-mass spectrometry 10/17/2018
Innovations in Glycan Analysis on the PA 800 Plus, LC-MS and CESI-MS 03/10/2018
Intact Casein-A Model System for the Separation of Intact Phosphorylated Proteins by CESI-MS 01/25/2018
CESI 8000 High Performance Separation - ESI Module 01/15/2018
Improving the Detection Limits for Highly Basic Neuropeptides Using CESI-MS 01/10/2018
Ultra-sensitive Host Cell Protein Dection using CESI-MS with SWATH Acquisition 12/10/2017
Neutral OptiMS Cartridge Instruction Guide 08/31/2017
Expanding phosphorylation and post translational site mapping in proteomics using CESI-MS 08/24/2017
Detecting Challenging Post Translational Modifications (PTMs) using CESI-MS 08/20/2017
Solutions for Biotherapeutic Characterization 08/01/2017
Von Einzelmethoden zur Multimethode für polare Pestizide: Ist CESI-MS die Lösung 05/24/2017
Are Pork Extracts Present in My Gummy Bears? Gelatin Speciation by LC-MS/MS-poster 04/26/2017
CESI 8000 Plus paired with the TripleTOF 6600 for the analysis of Protein Therapeutics 02/28/2017
Improving Identification and Quantification of Polar Herbicides by CESI-MS 01/03/2017
Structural Characterization of Antibody Drug Conjugates (ADCs) By a Combination of Intact, Middle-up and Bottom-up Approaches Using CESI-MS 12/20/2016
Quantitation of Nucleotides and Nucleosides without derivatization using CESI-MS 12/15/2016
Unified workflow for monoclonal antibody charge heterogeneity 12/12/2016
Improved CESI-MS Glycopeptide Analysis using a Dopant Enriched Nitrogen Gas 12/09/2016
CESI-MS comparison of tryptic diges an assessment of bio similarity 11/28/2016
Intact Proteoform Characterization using CESI-MS 11/18/2016
CESI 8000 Plus OptiMS Adapter Kits 11/10/2016
Analysis of Intact MUPs (Major Urinary Proteins) from Mice by CESI-MS 11/09/2016
CESI-MS for Multilevel Characterization of Protein Therapeutics 10/12/2016
Highly Efficient and Sensitive Anionic Metabolic Profiling by Mass Spectrometry 09/12/2016
Solutions to Advance your Metabolomics Research 08/17/2016
Analysis of Disease-Induced Protein Mods Using CESI-MS 08/12/2016
Separations Part Number Catalog 08/01/2016
Method for CESI-MS Separation for Waters MS 08/01/2016
Waters Adapter Installation Guide 08/01/2016
Bruker Installation Guide 08/01/2016
CESI 8000 Plus High Performance Separations - OptiMS Adapter kit 07/12/2016
CESI-MS Separation Method for Bruker MS 07/08/2016
Glycomics and Glycoproteomics by CESI-MS for Biomarker Discovery and Biopharmaceutical Characterization 06/15/2016
UHPLC-ESI-QTOF-MS/MS based Lipidomics by Data-independent Acquisition 05/11/2016
Studying Kinetics of Chromatin Assembly with SWATH MS 05/11/2016
The Lipidyzer- a new platform for quantitative Lipidomics 05/11/2016
CESI-MS a technique for the characterization and analysis of both intact and digested biopharmaceuticals 05/11/2016
CESI 8000 Plus for CESI-MS Ease of Use 05/01/2016
Innovation for Biotherapeutic Comparability with BioPharmaView Software Solution Guide 05/01/2016
Capillary Electrophoresis and CESI-MS for Characterization of BioSimilars: rhuEPO 04/13/2016
OptiMS Adapter Kit Data Sheet 04/10/2016
Antibody-Drug Conjugate Structural Characterization – Part 1: Analysis of Conjugation Site DAR 03/16/2016
OptiMS Thermo MS Adapter Installation Guide 03/01/2016
Multilevel Characterization of Biologics with a Single Method 02/17/2016
Multilevel Characterization of Biologics with a Single Method-Jpn 02/17/2016
High resolution approach to the detection of insulin degradation products 02/16/2016
A new approach to the analysis ofanionicmetabolites by CESI-MS with negative ion electrospray ionization 02/16/2016
Host cell protein detection using CESI-MS with SWATH 02/09/2016
nanoVial brochure 01/15/2016
Conditioning Method Neutral Cartridge CESI 8000 Plus 01/15/2016
Peptide Separations Method Neutral Cartridge CESI 8000 Plus 01/15/2016
Protein Separations Method Neutral Cartridge CESI 8000 Plus 01/15/2016
General Separations Methods Other Than Peptides and Proteins Neutral Cartridge CESI 8000 Plus 01/15/2016
Unification of Charge Heterogeneity, Purity, and Molecular Weight Analyses of mAbs into a Single Analysis 12/05/2015
Separations Product Overview 12/01/2015
Neutral OptiMS Capillary Data Sheet 12/01/2015
CESI How to (short) for E-book 12/01/2015
Increasing Throughput with Multi-Segment-Injection-MSI-CESI-MS 10/01/2015
Analysis of Anionic Metabolites by CESI-MS 10/01/2015
Compact Quantitative Proteomics Workflow Combining SILAC Labeling, Chromatographic pre-fractionation and CESI-MS with Neutral Capillary Surface 10/01/2015
Ionization efficiency, Ion Suppression and Detection Sensitivity of CESI-MS 10/01/2015
New High Resolution approach to the Detection of Insulin Degradation products 10/01/2015
New Approach to the Analysis of Anionic Metabolites by CESI-MS with Negative ion Electrospray Ionization 10/01/2015
Metabolomics: New technology needed for depper understanding of Biological functions in sample-limited cases 10/01/2015
Chiral Analysis of Methamphetamine and it’s Metabolite, Amphetamine in Urine by CESI-MS 09/10/2015
ExionLC AC Series Extended Specifications 09/01/2015
Sensitive Glycoform Profiling of b-Interferon-1a (Avonex) and recombinant human Erythropoietin by CESI-TOF-MS 09/01/2015
Separation and Analysis of Intact Prostate Specific Antigen (PSA) and its Proteoforms by CESI-MS Under Native and Denaturing Conditions. 09/01/2015
A covalent, cationic polymer coating method for the CESI-MS analysis of intact proteins and polypeptides 08/31/2015
Comprehensive Analysis of Recombinant Human Erythropoietin Glycoforms by Capillary Electrophoresis and Nanoflow Liquid Chromatography Coupled with Intact/Middle-Down Mass Spectrometry 08/30/2015
Characterization of Phospho- and Glycopeptides by CESI-MS: A Powerful Technique for Increasing Sensitivity 07/01/2015
Ultra-sensitive Host Cell Protein Detection using CESI-MS with SWATH Acquisition 06/01/2015
Breakthrough Applications to Expand and Speed Biopharmaceutical Characterization 06/01/2015
Characterization of Intact Prostate Specific Antigen (PSA) and Its proteoforms by CESI-MS under Native and Denaturing Conditions 06/01/2015
Comprehensive characterization of three IgG forms using CESI-MS 06/01/2015
In-line Separation by Capillary Electrophoresis Prior to top-down Mass Spectrometric Analysis enables Sensitive Characterization of Proteoforms 06/01/2015
The Application of Capillary Electrospray Ionization with Negative Ion Electrospray Ionization for the Analysis of Plant Metabolites 06/01/2015
The Effect of Ultra-low Flow on the Ionization of Biotherapeutics 06/01/2015
The Use of Capillary Electrophoresis Coupled to Mass Spectrometry (CESI-MS) for Quantitation of Nucleotides and Nucleosides 06/01/2015
Coffee at the Conference #1: Meeting Rawi Ramautar 06/01/2015
P213W Ultralow ESI-MS Flow Rates Make a Difference in The Analysis of Biotherapeutics 01/28/2015
P223W Evaluating the Addition of Supercharging Reagents During CESIMS for Identification and Characterization of Biopharmaceuticals 01/28/2015
Application of CESI-MS on SILAC-based Quantitative Proteomics 09/30/2014
Complete Primary Structure and Biosimilarity Assessment of Monoclonal Antibodies in a Single Analysis from a Single Enzyme Using CESI-Tandem Mass Spectrometry 09/30/2014
Introduction to CESI-MS Meeting 09/30/2014
Monoclonal antibodies complete primary structure and biosimilarity assessment in a single analysis using CESI–MS-MS 09/30/2014
Qualitative and Quantitative Analysis of Post-translational Modifications Using CESI-MS 06/23/2014
Comprehensive Analysis of Recombinant Human Erythropoietin Glycoforms by Capillary Electrophoresis and Nanoflow Liquid Chromatography Coupled with Middle-down Mass Spectrometry 06/18/2014
Monoclonal antibodies primary structure and biosimilarityassessment in a single analysis using transient isotachophoresissheathlesscapillary electrophoresis-tandem mass spectrometry 06/15/2014
Evaluating the Addition of Supercharging Reagents During CESI-MS for Identification and Characterization of Biopharmaceuticals 06/01/2014
Comprehensive Characterization of Trastuzumab using a Single-Shot Peptide Mapping Approach with CESI-MS 04/14/2014
CESI-MS Analysis of Biofluids of Basic Drugs and Metabolites 04/14/2014
Rapid Characterization of Biologics with  CESI-QExactive 04/07/2014
Efficient and Sensitive Characterization of Intact Proteins of Pharmaceutical Interest by CESI-MS 09/01/2011
An Introduction to CESI-MS 06/05/2011
CESI-MS of Intact Proteins 06/01/2011
Analysis of Fentanyl and It's Metabolite, Norfentanyl by CESI-MS (11-08008-P) 04/07/2008
Unleashing the Power of Your Mass Spectrometer Using Ultra Low Flow CESI 06/01/2005
Using CESI to Improve LOD & LOQ of Pharmaceuticals and Their Metabloites 06/01/2005
New Horizons for Metabolic Profiling of Urine
High Resolution Intact Glycoprotein Analysis by CESI-MS (11-0809-P)
Sheathless Capillary Electrophoresis - Mass Spectrometry (P-14618)
Analyzing Intact Proteins and Protein Complexes with CESI-MS
CE-ESI-MS MS as a tool in Protein Glycosylation Analysis
CE - Separation of Multiphosphorylated H1b
Generate High Resolution Separations of Intact Peptides for Online MS Analysis (CESI)
Generate High Resolution Separations of Intact Peptides for Online MS Analysis
Monoclonal antibodies complete primary structure and biosimilarity assessment in a single analysis using CESI-MS-MS
Multilevel Characterization of Biotherapeutics using CESI-MS: from Intact Protein to Peptide Mapping Approach
Polar Pesticide Analysis by CESI-MS
Probing a new volume regime in metabolomics by CESI
Therapeutic antibodies and related products design manufacturing and controls
Introducing the CESI 8000 High Performance Separation-ESI Module
Overcoming the Challenges of Quantifying Highly Polar Amines
CESI 8000_3col3

More Dynamic, Efficient Processes

CESI-MS allows for a more robust system with ultra-low-flow < 10 nL/min, into the mass spectrometer resulting an overall increase in ionization efficiency.

Minute Sample Consumption

Samples are often limited in quantity. CESI-MS has nL sample consumption, leaving most of the material available for analysis by orthogonal techniques.

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SWATH® Acquisition

Streamline Your Workflow

Use the same method and reagents for multi-level characterization of protein therapeutics. Switch between pos and neg ion modes without changing setup.

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SelexION Technology

Frustration Free

Open tube technology eliminates frustrations common with nanoscale techniques. No more minimizing dead volumes, or dealing with carryover and clogs.

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Food Fraud Analysis

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Proteomics by CESI-MS

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Metabolomics by CESI-MS

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Pesticide Testing

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CESI 8000_table
Key Features
Dimensions 29.2 in (74.2 cm) H x 25 in (63.5 cm) W x 28.4 in (72.1 cm) D
Portable Lab Bench 36 in x 30 in (91.4 cm x 76.2 cm)
Height adjusts 27 in to 44 in (69 - 112 cm)
Weight (uncrated) 188 lbs (85.3 kg)
Electrical Requirements Voltage: 100 - 240 V; 50/60 Hz
Sample Trays 2 x 48 CESI vials / 0.3 mL microvials
Buffer Tray 2 x36 CESI vials
Pressure Delivery Range -5 to +100 PSI
Required Sample Volume 5 μl when using NanoVias
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CESI 8000_resources
CESI 8000_Image_callout
1. Zero Dead Volume

Single continuous separation capillary is contained within the OptiMS cartridge

2. Multi-Detection Capability

In stand-alone CE mode, UV/VIS, PDA, or LIF detection can be selected

CESI 8000
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3. Multiple Injections from Precious Samples

Sample analysis from as little as 5 μL

CESI 8000_Tripanel

Watch Video

See Why There’s Nothing Else Like the CESI 8000 Plus

Intact Proteoform Characterization using CESI-MS

Length 29:55 min

Glycomics for Biomarker Discovery and Biopharma

Length 61:24 min

CESI 8000

Length 35:32 min

CESI 8000_imgleft_1col

Expand the Reach of Your Mass Spectrometer

The integration of Capillary Electrophoresis with Electrospray Ionization into a single dynamic process within the same device brings new capabilities to researchers.

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AB Sciex is doing business as SCIEX. © 2010-2019 AB Sciex. The trademarks mentioned herein are the property of the AB Sciex Pte. Ltd. or their respective owners. AB SCIEX™ is being used under license. Beckman Coulter® is being used under license. Product(s) may not be available in all countries. For information on availability, please contact your local representative. For research use only. Not for use in diagnostic procedures.