PA 800 Plus Pharmaceutical Analysis System

Perform consistent and compliant biotherapeutics characterization faster than ever

With the PA 800 Plus system, you can confidently safeguard the success of your biologics, run multiple characterizations from a single system that biopharma labs depend on, and produce qualitative and quantitative analyses with speed and confidence.

The PA 800 Plus system is a robust analytical, kit-based platform that can help you with:

Monoclonal antibody and next-generation protein applications

Purity/Heterogeneity with gold standard CE-SDS in minutes
Glycan analysis with award-winning Fast Glycan technology
Charge heterogeneity with fast and simple CZE or with hi-res cIEF

Gene therapy and nucleic acid applications

mRNA purity and integrity analysis
Capsid protein purity
AAV Empty vs. Full
Plasmid and linear double-stranded DNA (dsDNA) analysis
Small RNA or DNA analysis

Cell therapy

Key features
Multiple applications, one platform	Run multiple characterizations from a single system to improve your operational efficiency and effectiveness.
Raw unmanipulated data	Have the confidence critical to both you and regulatory agencies for product submission and commercialization with raw, unmanipulated data.
Reproducibility matters	Get repeatable results with exclusive recirculating liquid coolant to control separation temperature precisely.
Portability matters	Easily transfer methods using robust, automated assays with proven portability ‐ ideal for global multi-user, multi-instrument.

Key features

Multiple applications, one platform

Run multiple characterizations from a single system to improve your operational efficiency and effectiveness.

Raw unmanipulated data

Have the confidence critical to both you and regulatory agencies for product submission and commercialization with raw, unmanipulated data.

Reproducibility matters

Get repeatable results with exclusive recirculating liquid coolant to control separation temperature precisely.

Portability matters

Easily transfer methods using robust, automated assays with proven portability ‐ ideal for global multi-user, multi-instrument.

Industry and regulatory proven CE technology

The PA 800 Plus system is a robust analytical platform so you can have confidence in your data, without sacrificing speed.

Increase Efficiency

Running multiple assays on one platform simplifies staff training, maximizes ROI and reduces laboratory footprint.

Trust your assays

Extensive intercompany studies demonstrate the robustness of SCIEX capillary electrophoresis assays, encompassing CE-SDS, cIEF, CZE, and glycan analysis.

Simplify compliance

The USP has included validated procedures and system suitability criteria for IgG purity and heterogeneity analysis by capillary electrophoresis.

Maximize sensitivity

Achieve as low as 0.01% impurity detection, with at least three orders of magnitude of impurity, with modular detection (UV, PDA, LIF)

Automated and quantitative analysis of biotherapeutics

Generate highly reproducible data with PA 800 Plus system quantitative and automated solutions. Our engineers have collaborated closely with biopharma development and QC groups experienced in biologics characterization to create assays that address your analytical challenges.

Protein purity analysis

Quantitative protein purity analysis with SDS-gel capillary electrophoresis

Learn more

Glycan analysis

Run glycans faster than HILIC with simplified sample preparation, rapid, high-resolution separations, and automated glycan identification.

Learn More

Charge heterogeneity

Conduct advanced capillary isoelectric focusing (cIEF) and hi-speed capillary zone electrophoresis (CZE) for charge heterogeneity analysis.

Learn more

Peptide/Protein characterization

Analyze peptide and protein biotherapeutics beyond mAbs.

Learn More

Gene therapy and nucleic acid analysis

Analyze a variety of single-stranded and double-stranded oligos and fragments with kit-based solutions.

Learn more

Specifications
PA 800 Plus system (P/N: A66528)	Includes separation module with UV, photodiode array and LIF detection and system controller with PA 800 Plus software.
PA 800S Plus system (P/N: A66527)	Includes separation module with photodiode array detection and system controller with PA 800 Plus software.
Dimensions	Height: 29.2 in (74.2 cm) Door open: 38.8 in (98.6 cm) Width: 25 in (63.5 cm) Depth: 28.4 in (72.1 cm)
Weight (uncrated)	188 lbs (85.3 kg) (includes photodiode array detection)
Electrical requirements	Voltage: 100 - 240 V; 50/60 Hz
Voltage range	1 to 30 kV programmable at 0.1 kV increments
Current range	3 to 300 μA programmable at 0.1 μA increments
Pressure delivery range	-5 to +100 PSI
Sample temperature control	4 - 60°C
Capillary temperature control	15 - 60°C
Sample trays: 2 x 96-well plates	2 x 48 universal vials 2 x 48 0.2 mL microvials
Buffer tray	2 x 36 universal vials
Detection capability	UV/Vis 200, 214, 254, 280 nm standard filter 190 - 600 nm (custom filter option) Diode array 190 - 600 nm (programmable) 0.5 - 32 Hz scan collection frequency (programmable) Laser induced fluorescence (LIF) 300 - 700 nm excitation range 350 - 750 nm emission range 0 - 1000 RFU
Source lasers with 3 mW power output (P/N: A66528)	488 nm solid-state laser (included in P/N: A66528)

Specifications

PA 800 Plus system (P/N: A66528)

Includes separation module with UV, photodiode array and LIF detection and system controller with PA 800 Plus software.

PA 800S Plus system (P/N: A66527)

Includes separation module with photodiode array detection and system controller with PA 800 Plus software.

Dimensions

Height: 29.2 in (74.2 cm)
Door open: 38.8 in (98.6 cm)
Width: 25 in (63.5 cm)
Depth: 28.4 in (72.1 cm)

Weight (uncrated)

188 lbs (85.3 kg) (includes photodiode array detection)

Electrical requirements

Voltage: 100 - 240 V; 50/60 Hz

Voltage range

1 to 30 kV programmable at 0.1 kV increments

Current range

3 to 300 μA programmable at 0.1 μA increments

Pressure delivery range

-5 to +100 PSI

Sample temperature control

4 - 60°C

Capillary temperature control

15 - 60°C

Sample trays: 2 x 96-well plates

2 x 48 universal vials 2 x 48 0.2 mL microvials

Buffer tray

2 x 36 universal vials

Detection capability

UV/Vis
200, 214, 254, 280 nm standard filter
190 - 600 nm (custom filter option)
Diode array
190 - 600 nm (programmable)
0.5 - 32 Hz scan collection frequency (programmable)
Laser induced fluorescence (LIF)
300 - 700 nm excitation range
350 - 750 nm emission range
0 - 1000 RFU

Source lasers with 3 mW power output (P/N: A66528)

488 nm solid-state laser (included in P/N: A66528)

A sensitive and robust plasmid analysis method by capillary electrophoresis-laser induced fluorescence (Pfizer and SCIEX) poster

Achieving robust cIEF analysis of monoclonal antibodies while increasing capillary run-life and maintaining high resolution and reproducibility

Optimization of a robust and sensitive capillary electrophoresis laser induced flourescence method for monitoring plasmid stability and purity

Determination of free carrier proteins in polysaccharideprotein conjugate vaccines by capillary micellar electrokinetic chromatography (ZH)

Purity analysis of monoclonal antibodies (5-TAMRA labeling) by CE-SDS-LIF (ZH)

SCIEX CE solutions in China Pharmacopoeia (ZH)

Determination of P-carboxybenzaldehyde and P-methyl benzoic acid in P-terephthalic acid by capillary electrophoresis (ZH)

Comparation the N-Glycan of different sources recombinant human erythropoietin by using capillary electrophoresis with laser-induced fluorescence detector (ZH)

Learning Center
Installing the LIF aperture and probe guide/Stabilizer step-by-step Video Guide	Watch
Cartridge removal, rebuild and reinstallation step-by-step video guide	Watch
Change the coolant tubing step-by-step video guide	Watch
Change a detector step-by-step video guide	Watch
Capillary removal step-by-step video guide	Watch
Capillary storage step-by-step video guide	Watch
Fast Glycan software	Download
How to maximize your capillary life flyer	Download

Watch

Cartridge removal, rebuild and reinstallation step-by-step video guide

Watch

Change the coolant tubing step-by-step video guide

Watch

Change a detector step-by-step video guide

Watch

Capillary removal step-by-step video guide

Watch

Capillary storage step-by-step video guide

Watch

Fast Glycan software

Download

How to maximize your capillary life flyer

Download

Analytical flow

Ultra-low Flow

Clinical Research

Food and beverage testing

Environmental testing

Pharma BioPharma

Forensics

Instrument control software

Workflow module software

Application module software

High resolution libraries

QTRAP libraries

Kits

Reagents

Food Omics

Quick Links

Get Help

Customer Documents

For contacts

For support

For public relations

Characterize therapeutic molecules with confidence on the PA 800 Plus system

Perform consistent and compliant biotherapeutics characterization faster than ever

Precision analytics for oligonucleotide, cell and gene therapy

Multiple biotherapeutic characterizations on one platform

Biologics characterization results you can trust

Transferability

EZ-CE cartridge

Trusted, fast and accurate biotherapeutic characterization

Industry and regulatory proven CE technology

Increase Efficiency

Trust your assays

Simplify compliance

Maximize sensitivity

You can do all this on your PA 800 Plus system

Automated and quantitative analysis of biotherapeutics

Protein purity analysis

Glycan analysis

Charge heterogeneity

Peptide/Protein characterization

Gene therapy and nucleic acid analysis

Run glycans faster than HILIC

Glycoprotein to identified glycans within record 90 minutes

minute

Empower your PA 800 Plus system with the SCIEX Empower Driver version 1.3

Stay connected with Chromeleon

Windows 10 upgrade

Related products

Kit-based assays

EZ-CE cartridge

Connect to a mass spec

Resources