AB Sciex is doing business as SCIEX. © 2010-2019 AB Sciex. The trademarks mentioned herein are the property of the AB Sciex Pte. Ltd. or their respective owners. AB SCIEX™ is being used under license. Beckman Coulter® is being used under license. Product(s) may not be available in all countries. For information on availability, please contact your local representative. For research use only. Not for use in diagnostic procedures.
The PA 800 Plus is a robust analytical platform that provides characterization of product purity, charge heterogeneity and glycan analysis, to help you with the development and quality control of therapeutic proteins.
Intelligent features to enhance your operational efficiency:
To find out how the PA 800 Plus can help you, request your samples to be analyzed now.
Variations in biotherapeutics affect the safety and efficacy of patient treatment and the reputation of your organization. With the PA 800 Plus Pharmaceutical Analysis System, you can confidently safeguard the success of your biologics. Run multiple characterizations from a single system that biopharma labs depend on, and produce qualitative and quantitative analyses, with speed and confidence.
The PA 800 Plus Pharmaceutical Analysis System is a robust analytical platform that provides characterization of product purity, charge heterogeneity, and glycan analysis, to help you with the development and quality control of therapeutic proteins.
You can do ALL this on the PA 800 Plus
Characterize molecules, large or small, with industry and regulatory compliant capillary electrophoresis (CE) technology. It’s why every biopharmaceutical company with therapeutic IgGs currently on the market uses SCIEX CE systems in their bioanalytical processes.
For research use only. Not for use in diagnostic procedures.
|High Efficiency Evaporative Fluorophore Labeling Of Glycans||11/19/2018|
|Using Fluorescent Labels to Increase the sensitivity of IgG Purity and Heterogeneity Assay on PA 800 plus||11/17/2018|
|Quantitation of Somatropin Charge Variants Impurities by Capillary Zone Electrophoresis (CZE)||11/07/2018|
|Rediscover the Strengths of Your PA 800 Plus A Multi-Attribute Protein Analyzer||11/06/2018|
|PA 800 Plus Methods Development Guide||11/01/2018|
|PA 800 Plus System Maintenance Guide||11/01/2018|
|Method Optimization and Evaluation for RNA Purity Analysis Using CE-LIF Technology||09/10/2018|
|IgG Purity-Heterogeneity and SDS-MW Assays with 96-Well Plate Adaption||08/01/2018|
|Better Characterize Your New Biologics with Robust Hi-Res Charge Het||07/19/2018|
|Assessing Glycosimilarity of Biotherapeutics||06/27/2018|
|Characterization of the Fc domain N-glycosylation in mAb and fusion protein therapeutics by CGE-LIF vs UPLC-FL||06/27/2018|
|High Throughput Off Platform Biopharma Method Development Using 96 Well Plate Format and CE-SDS||06/01/2018|
|PA 800 plus Pharmaceutical Analysis System Brochure||05/09/2018|
|A Single Analytical Platform for Glycan Analysis, Charge Heterogeneity, and Purity Determination of the NISTmAb||05/04/2018|
|The Importance of Temperature Control in Capillary Electrophoresis of Carbohydrates||04/30/2018|
|Clinical IVD LC-MS-MS Systems||04/10/2018|
|SDS-MW Analysis Kit Application Guide||04/01/2018|
|Carbohydrate Labeling and Analysis Kit Application Guide||04/01/2018|
|Innovations in Glycan Analysis on the PA 800 Plus, LC-MS and CESI-MS||03/10/2018|
|Purity, Identity, Heterogeneity Solutions Guide||03/10/2018|
|PA 800 Plus Site Planning Guide||03/01/2018|
|IgG Purity and Heterogeneity Assay Kit Application Guide||03/01/2018|
|Achieving Robust cIEF Analysis of Monoclonal Antibodies While Increasing Capillary Run-Life and Maintaining High Resolution and Reproducibility||03/01/2018|
|Capillary Isoelectric Focusing (cIEF) Analysis Application Guide||02/01/2018|
|PA 800 Plus Software Validation Pack||02/01/2018|
|PA 800 Plus System Overview Guide||01/10/2018|
|Robust cIEF Method: Intermediate Precision for the pH 5-7 Range||01/05/2018|
|Assay of IgG Purity and Heterogeneity Using High-Resolution Sodium Dodecyl Sulfate Capillary Gel Electrophoresis (AIB A-1973)||01/05/2018|
|Capillary Electrophoresis in Quality Control: Part I: Application for Therapeutic Proteins||01/05/2018|
|Capillary Electrophoresis in Quality Control: Part II: CE-SDS: Method Development and Robustness||01/05/2018|
|SCIEX Fast Glycan Labeling and Analysis Technology||01/05/2018|
|PA 800 Plus System Administration Guide||01/01/2018|
|Holistic Approach to Understanding cIEF||12/28/2017|
|Capillary Electrophoresis with Indirect Ultraviolet Detection for Pharmaceutical Counterion Analysis||12/28/2017|
|High-Resolution cIEF of Therapeutic Monoclonal Antibodies: A Platform Method Covering pH 4-10 (AIB A-12026)||11/28/2017|
|Identification of System Parameters Critical for High-Performance cIEF (AIB A-11634)||11/28/2017|
|Automation of PA 800 plus CE-SDS Assays (IB-18278)||11/25/2017|
|Fast Glycan Sequencing Using a Fully Automated Carbohydrate Sequencer||09/14/2017|
|PA 800 Plus Carbohydrate Labeling and Analysis Guide||09/08/2017|
|Automated and Quantitative Analysis of Biologics with PA 800 Plus Pharmaceutical System||08/01/2017|
|mAb Characterization-Purity, Charge Heterogeneity and Glycan Analysis on a Single Platform Technology||06/22/2017|
|Sample Preparation for the Fast Glycan Technology on the PA 800 Plus||06/15/2017|
|Fast Glycan Labeling and Analysis Kit Application Guide||06/12/2017|
|CE Installation Qualification Guide||05/01/2017|
|Complementary Study of the N-linked Glycosylation Profiling of a Therapeutic Glycoprotein||01/31/2017|
|Quantitative Results for N-Glycan, CE-SDS and Charge Heterogeneity Applications||10/19/2016|
|Separations Part Number Catalog||08/01/2016|
|Charge Heterogeneity Analysis of Biologics by High Resolution cIEF and High Throughput CZE Methods||06/29/2016|
|Automated and Quantitative Analysis of Biologics using the PA 800 Plus Pharma||04/12/2016|
|PA 800 Installing the Cartridge Aperture||04/07/2016|
|Installing the LIF Aperture and Probe Guide/Stabilizer||04/01/2016|
|PA 800 Installing the LIF detector||04/01/2016|
|PA 800 Trimming a Capillary||04/01/2016|
|PA 800 Uninstalling the LIF detector||04/01/2016|
|Biopharma CE Method Compliance in a Global Market||03/23/2016|
|Fully Automated One Hour Sample Preparation for Ultrafast N-Glycosylation Analysis of Antibody Therapeutics||03/10/2016|
|PA 800 Cartridge Installation||03/01/2016|
|Removing the Ejector and Electrode on the PA 800 plus and PA 800 Enhanced||03/01/2016|
|Replacing the Ejector and Electrode on the PA 800 plus and PA 800 Enhanced||03/01/2016|
|PA 800 Cartridge Removal||02/01/2016|
|mAb charge heterogeneity analysis by CZE Part 3: A Test Method Fit for QC Testing||07/02/2015|
|mAb charge heterogeneity analysis by CZE Part 2: A case Study from Merck Sharp and Dohme||06/30/2015|
|mAb Charge Heterogeneity Analysis by CZE Part 1 Results of an Intercompany Robustness Study||06/18/2015|
|P-101-T New Methodology to Rapidly Identify Responders During Infliximab Treatment in Inflammatory Diseases||01/28/2015|
|P217W Fully Automated Sample Preparation with Ultrafast N-Glycosylation Analysis of Therapeutic Antibodies||01/28/2015|
|Sample preparation of mAb N-glycans using Magnetic Bead Technology and CE-LIF||11/25/2014|
|Purity Analysis of Bispecific Antibodies by Affinity Capillary Electrophoresis||10/02/2014|
|Characterizing Biologics Virtual Workshop||09/23/2014|
|Characterizing Biologics Virtual Workshop||09/23/2014|
|Cartridge Removal, Rebuild and Reinstallation||05/09/2014|
|Changing a Detector||05/09/2014|
|PA 800 Capillary Removal||05/09/2014|
|PA800 Cartridge Changing the Coolant Tubing||05/09/2014|
|PA 800 Removing the Ejector and Electrode on the PA 800 plus and PA 800 Enhanced||05/09/2014|
|Rapid Characterization & Assessment of Candidate Biosimilars Part 1||04/07/2014|
|Automation of CE-SDS Sample Preparation for PA 800 plus CE-SDS Assays||01/01/2014|
|What Pesticides Have You Eaten Today||05/02/2012|
|PA 800 Change a Detector||11/03/2011|
|PA 800 Changing the Coolant Tubing||11/03/2011|
|PA 800 Cartridge Removal Rebuild and Reinstallation||11/03/2011|
|PA 800 Installing the Cartridge Aperture||05/09/2009|
|Utilizing Capillary Electrophoresis in a Quality Control Environment||04/22/2009|
|Capillary Ion Electrophoresis in Drug Discovery|
|CE Theory and Applications in Biopharma|
|Characterizing Biologics Virtual Workshop|
|cIEF in BR&D Analytical Development Webinar|
|Consistent, Confident and Compliant mAb Purity Results|
|Database Assisted Capillary Electrophoresis for Analytical Glycomics|
|Robust CE Methods: A Biomolecule Intercompany Collaboration as a Tool to Understand Method Variability|
|Rapid Magnetic bead based Sample Preparation for Automated and High Throughput N-glycan Analysis of Theraputic Antibodies|
|Measuring the Capillary|
|PA 800 Capillary Stoage|
|A66528 PA 800 Plus Pharmaceutical Analysis System||Includes separation module with UV, photodiode array and LIF detection; system controller with PA 800 Plus software; system startup kit and reagents|
|A66527 PA 800S Plus Pharmaceutical Analysis System||Includes separation module with photodiode array detection; system controller with PA 800 Plus software; system startup kit and reagents|
|Dimensions||Height: 29.2 in (74.2 cm)
Door Open: 38.8 in (98.6 cm)
Width: 25 in (63.5 cm)
Depth: 28.4 in (72.1 cm)
|Weight (uncrated)||188 lbs (85.3 kg) (includes photodiode array detection)|
|Electrical Requirements||Voltage: 100 - 240 V; 50/60 Hz|
|Voltage Range||1 to 30 kV programmable at 0.1 kV increments|
|Current Range||3 to 300 μA programmable at 0.1 μA increments|
|Pressure Delivery Range||-5 to +100 psi|
|Sample Temperature Control||4 - 60°C|
|Capillary Temperature Control||15 - 60°C|
|Sample Trays: 2 x 96-well plates||2 x 48 universal vials 2 x 48 0.2 mL microvials|
|Buffer Tray||2 x 36 universal vials|
200, 214, 254, 280 nm standard filter
190 - 600 nm (custom filter option)
190 - 600 nm (programmable)
0.5 - 32 Hz scan collection frequency (programmable)
Laser Induced Fluorescence (LIF)
300 - 700 nm excitation range
350 - 750 nm emission range
0 - 1000 RFU
|Source Lasers with 3 mW Power Output||488 nm solid-state laser (included in A66528)|
The PA 800 Plus Pharmaceutical Analysis System is a robust analytical platform so you can have confidence in your data, without sacrificing speed.
Running multiple assays on one platform simplifies staff training, maximizes ROI and reduces laboratory footprint.
Extensive intercompany studies demonstrate the robustness of SCIEX capillary electrophoresis assays, encompassing CE-SDS, cIEF, CZE, and glycan analysis.
The USP has included validated procedures and system suitability criteria for IgG Purity and heterogeneity analysis by capillary electrophoresis.
Get the reagents you need to run your experiments with one of the broadest selections of kit-based assays.
The convenient EZ-CE cartridge is ready-to-use across multiple applications.
Generate highly reproducible data with PA 800 Plus quantitative and automated solutions. Our engineers have collaborated closely with biopharma development and QC groups experienced in biologics characterization to create assays that address your analytical challenges.
Installing the LIF Aperture and Probe Guide/Stabilizer Step-by-Step Video Guide
Cartridge Removal, Rebuild and Reinstallation Step-by-Step Video Guide
Change the Coolant Tubing Step-by-Step Video Guide
Change a Detector Step-by-Step Video Guide
Capillary Removal Step-by-Step Video Guide
Capillary Storage Step-by-Step Video Guide
CE-SDS MW Application Guide
Glycan Analysis Application Guide
Fast Glycan Software
Sample Preparation for the Fast Glycan Technology on the PA 800 Plus
Fast Glycan Sequencing Using a Fully Automated Carbohydrate Sequencer
Develop and lock-down methods applicable to QC or regulated environments. Easily transfer methods using robust, automated assays with proven portability. Perfect for the global multi-user and multi-instrument organizations.
Run multiple protein characterizations from a single system to improve your operational efficiency and effectiveness.
Have the confidence critical to both you and regulatory agencies for product submission and commercialization with raw, unmanipulated data.
Get repeatable results with exclusive recirculating liquid coolant to control separation temperature precisely.
Easily transfer methods using robust, automated assays with proven portability ‐ ideal for global multi-user, multi-instrument
Part 3: A Test Method Fit for QC Testing
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