Characterize Therapeutic Proteins with Confidence on the PA 800 Plus

Perform Consistent and Compliant Biotherapeutics Characterization Faster than Ever

With the PA 800 Plus Pharmaceutical Analysis System, you can confidently safeguard the success of your biologics. Run multiple characterizations from a single system that biopharma labs depend on, and produce qualitative and quantitative analyses, with speed and confidence.

The PA 800 Plus is a robust analytical platform that can help you with:

  • Monoclonal Antibody Applications
    • Purity/Heterogeneity with Gold Standard CE-SDS in minutes
    • Glycan Analysis with award-winning Fast Glycan Technology
    • Charge Heterogeneity with fast and simple CZE or with hi-res cIEF
  • Peptides and Proteins beyond mAbs
  • Cell and Gene Therapy Applications
    • Capsid Proteins Purity
    • Nucleic Acid and Plasmid Analysis
PA 800 Plus Pharmaceutical Analysis System
Key Features

Multiple Applications, One Platform

Run multiple protein characterizations from a single system to improve your operational efficiency and effectiveness.

Raw Unmanipulated Data

Have the confidence critical to both you and regulatory agencies for product submission and commercialization with raw, unmanipulated data.

Reproducibility Matters

Get repeatable results with exclusive recirculating liquid coolant to control separation temperature precisely.

Portability Matters

Easily transfer methods using robust, automated assays with proven portability ‐ ideal for global multi-user, multi-instrument.

Precision Analytics for Oligonucleotide, Cell and Gene Therapy

As the technologies for manufacturing and analysis of gene therapy products continue to evolve, it’s important to keep up to date on growing industry trends and analytical advancements. This compendium can help advance your gene therapies and oligonucleotide therapeutics to the next level with the latest tools and methods.

Multiple Biotherapeutic Characterizations on ONE Platform

Biologics Characterization Results You Can Trust

Characterize molecules, large or small, with industry and regulatory compliant capillary electrophoresis (CE) technology. It’s why every biopharmaceutical company with therapeutic IgGs currently on the market uses SCIEX CE systems in their bioanalytical processes.

Transferability

Develop and lock-down methods applicable to QC or regulated environments. Easily transfer methods using robust, automated assays with proven portability. Perfect for the global multi-user and multi-instrument organizations.

EZ-CE Cartridge

The convenient EZ-CE cartridge is ready-to-use across multiple applications. Enhance data consistency and minimize staff training with the PA 800 Plus EZ-CE cartridge.

Trusted, Fast and Accurate Biotherapeutic Characterization

Industry and Regulatory Proven CE Technology

The PA 800 Plus Pharmaceutical Analysis System is a robust analytical platform so you can have confidence in your data, without sacrificing speed.

Increase Efficiency

Running multiple assays on one platform simplifies staff training, maximizes ROI and reduces laboratory footprint.

Trust Your Assays

Extensive intercompany studies demonstrate the robustness of SCIEX capillary electrophoresis assays, encompassing CE-SDS, cIEF, CZE, and glycan analysis.

Simplify Compliance

The USP has included validated procedures and system suitability criteria for IgG Purity and heterogeneity analysis by capillary electrophoresis.

Maximize Sensitivity

Achieve as low as 0.01% impurity detection, with at least three orders of magnitude of impurity, with modular detection (UV, PDA, LIF)

You Can Do ALL This on Your PA 800 Plus

Automated and Quantitative Analysis of Biotherapeutics

Generate highly reproducible data with PA 800 Plus quantitative and automated solutions. Our engineers have collaborated closely with biopharma development and QC groups experienced in biologics characterization to create assays that address your analytical challenges.

Protein Purity Analysis

Quantitative Protein Purity Analysis with SDS-Gel Capillary Electrophoresis

Glycan Analysis

Run glycans faster than HILIC with simplified sample preparation, rapid, high-resolution separations, and automated glycan identification.

Charge Heterogeneity

Conduct advanced capillary isoelectric focusing (cIEF) and hi-speed capillary zone electrophoresis (CZE) for charge heterogeneity analysis.

Peptide/Protein Characterization

Analyze peptide and protein biotherapeutics beyond mAbs.

Cell and Gene Therapy

Easily analyze viral vectors and nucleic acids.

SCIEX Biopharma Symposium

Gain access to on-demand content that highlights beginning to advanced capabilities of the PA 800 Plus. Visit our Biopharma Symposium to learn more.

Run Glycans Faster than HILIC

Empower your PA 800 Plus with the SCIEX Empower Driver version 1.3

Take control of your PA 800 Plus with Waters Empower 3 Chromatography Data Software (CDS) for data integrity compliance. Reduce regulatory risk and maximize method transfer efficiency with the newly released SCIEX Empower Driver version 1.3.

Windows 10 Upgrade

We Are Now Windows 10 Compatible! Upgrade Your SCIEX CE Instruments Today.

Related Products

Kit-based Assays

Get the reagents you need to run your experiments with one of the broadest selections of kit-based assays.

EZ-CE Cartridge

The convenient EZ-CE cartridge is ready-to-use across multiple applications.

Connect to a Mass Spec

Integrate CE with electrospray ionization (ESI) and connect to a mass spec with the CESI 8000 Plus.

Resources

Filter by Type:

Masterclass Live: Capsid protein, empty/full and transgene integrity on a single platform

Proven Answers for Protein, Vaccine and Gene Therapy Analysis - Mukesh Malik

ce-method.mp4

Meet the Experts: Viral vector characterization: empty/full, transgene integrity and capsid protein analyses on a single platform

ADC calculations made easy and simple

Genome integrity analysis of adeno-associated viruses (AAV) by genome sizing methodology

How are CE methods being adapted to analyze new modalities

PA使いこなすために 全般編

PA使いこなすために SDS ゲル電気泳動編

Peptide therapeutics analysis by Capillary Electrophoresis

使用 SCIEX 低pH SDS 样品缓冲液提高方法的稳定性

5 分钟轻松完成电荷异质性分析

2021 Biopharma New Product Launch Seminar - Flyer

2021 - Flyer - Start Up Group PA 800 Plus

PA 800 Plus Empower Driver User Guide (EN)

PA 800 Plus System Maintenance Guide

PA 800 Plus System Maintenance Guide (FR)

PA 800 Plus System Administration Guide (ES)

PA 800 Plus System Overview Guide (FR)

PA 800 Plus Empower Driver User Guide (DE)

PA 800 Plus System Maintenance Guide (ES)

PA 800 Plus System Administration Guide (FR)

PA 800 Plus Empower Driver User Guide (ES)

PA 800 Plus Pharmaceutical Analysis System Software Validation Summary

PA 800 Plus Empower Driver User Guide (IT)

PA 800 Plus Empower Driver User Guide (JA)

PA 800 Plus Empower Driver User Guide (ZH)

PA 800 Plus System Overview Guide (ES)

PA 800 Plus Empower Driver User Guide (FR)

LIFluor™ EnhanCE dsDNA 1000 Dye アプリケーションガイド

IgG Purity and Heterogeneity Assay Kit Application Guide (JA)

IgG Purity and Heterogeneity Assay Kit Application Guide (ZH)

PA 800 Plus Pharmaceutical Analysis System SDS-MW Analysis Kit Application Guide

ssDNA 100-R 试剂盒 应用指南

dsDNA 1000 Kit Application Guide

CZE Rapid Charge Variant Analysis Kit Application Guide (CN)

dsDNA 1000キット アプリケーションガイド

PA 800 Plus Pharmaceutical Analysis System cIEF Application Guide

ssDNA 100-R Kit Application Guide

LIFluor™ EnhanCE dsDNA 1000 Dye 应用指南

CZE Rapid Charge Variant Analysis Kit Application Guide (EN)

IgG純度および不均一性分析キット

PA 800 Plus Pharmaceutical Analysis System SDS-MW Analysis Kit Application Guide

LIFluor™ EnhanCE dsDNA 1000 Dye Application Guide

ssDNA 100-R アプリケーションガイド

CZE Rapid Charge Variant Analysis Kit Application Guide (JA)

dsDNA 1000 试剂盒 应用指南

Bring High Quality Buffer Production to Your Lab

CE Instrument Maintenance

Caracterice con Confianza

Agenda CE-SDS update Ger

CE Training Overview 2021

windows10-Announcement.pdf

Empower Your PA 800 Plus with Waters Empower3 Enterprise Software

Robust, Flexible Solutions for Cell and Gene Therapy

SCIEX Fast Glycan Labeling and Analysis Technology

Meet the Expert at your SCIEX Consultancy Day

Capillary electrophoresis kits

精简、全面的 LC-MS 多质量属性监控(MAM) 工作流程

Low pH Phosphate SDS Sample Buffer

LC-MS/MS 技术平台

助力疫苗研发

赋能 PA800 Plus-Water Empower 3 企业软件

SCIEX Capillary Electrophoresis Consumables Guide

Increase Method Robustness with SCIEX Low pH SDS Sample Buffer

Gene Therapy and Oligonucleotide Compendium

CE Training Overview DE 2021

Comprehensive Capillary Electrophoresis Training Course

SCIEX CZE Rapid Charge Variant Analysis Kit

PA 800 Plus Pharmaceutical Analysis System Brochure

Capillary Electrophoresis with Indirect Ultraviolet Detection for Pharmaceutical Counterion Analysis

No Slide Title

AB SCIEX

Kein Folientitel

Kein Folientitel

A sensitive and robust plasmid analysis method by Capillary Electrophoresis-Laser Induced Fluorescence

CZE Rapid Charge Variant Analysis

CZE Capillary Conditioning

CZE Shutdown

CZE Analysis

Low level quantitation of impurities in bispecific proteins using CE-SDS with LIF detection

Rapid CZE analysis of erythropoietin variants

Análisis Sensible de Impurezas de las Proteínas de la Cápside AAV por CE usando un Colorante Fluorescente Chromeo P503

Capillary Electrophoresis in Quality Control: Part I: Application for Therapeutic Proteins

Fast Glycan Labeling and Analysis Kit Application Guide

A Robust cIEF Method: Intermediate Precision

Assessing Glycosimilarity of Biotherapeutics

Microsoft Word - Sciex Plasmid Analysis TN Final.docx

TN-Evap_labeling-formated-verGA8 _v2

Achieving Robust cIEF Analysis of Monoclonal Antibodies While Increasing Capillary Run-Life and Maintaining High Resolution and Reproducibility

Accurate Analysis of Double Stranded DNA over an Extended Size Range

Assay of IgG Purity and Heterogeneity using High-Resolution Sodium Dodecyl Sulfate Capillary Gel Electrophoresis

Determination of Full, Partial and Empty Capsid Ratios forAdeno-Associated Virus (AAV) Analysis

Sensitive AAV Capsid Protein Impurity Analysis by CE Using

Preparation Scale-Up of Complex Biological Samples for Deep N-glycomic Analysis by CE-LIF and CESI-MS

Microsoft Word - 96 Well-Plate Final.docx

Purity Analysis of Adeno-Associated Virus(AAV) Capsid Proteins using CE-SDS Method

Native State Charge Variant Analysis of Commercialized Monoclonal Antibodies in Minutes

RNA Analysis for CRISPR by capillary electrophoresis with laser-induced fluorescence detection

Genome Sizing Methodology for Genome Integrity Analysis of Adeno-Associated Viruses (AAV)

Automation of CE-SDS for IgG Purity/Heterogeniety

Comparative characterization of the Fc domain N-glycosylation in monoclonal antibody and fusion protein therapeutics

Ultrafast Analysis of Human Milk Oligosaccharides (HMOs)

Capillary Electrophoresis in Quality Control: Part II: CE-SDS: Method Development and Robustness

Separation of Recombinant Human Erythropoietin (rhEPO) using the European Pharmacopoeia Method on the PA 800 plus Pharmaceutical Analysis System

Simplifying CE-SDS Data Processing

Strengths of PA 800 Plus for Multi‐Attribute Protein Analyzer

Method_Optimization.pdf

Velocity-corrected area calculation SCIEX PA 800 Plus Empower Driver version 1.3 vs. 32 Karat Software

Identification of System Parameters Critical for High-Performance cIEF (AIB A-11634)

Automated Fast Glycan Sequencing

Purity Analysis of Adeno-Associated Virus (AAV) Capsid Proteins using CE-LIF Technology

Evaluación de la glicosimilaridad de bioterapéuticos

Optimize Non-Reduced CE-SDS Analysis with the SCIEX Low pH SDS Sample Buffer

SDS-MW calibration and molecular weight estimation using the SCIEX PA 800 Plus Empower Driver version 1.3

Optimization of a Robust and Sensitive Capillary Electrophoresis- Laser Induced Flourescence Method for Monitoring Plasmid Stability and Purity

High-Resolution cIEF of Therapeutic Monoclonal Antibodies

A Single Analytical Platform for Glycan Analysis, Charge Heterogeneity, and Purity Determination of the NISTmAb Fast Methods to Maximize the Use of the PA 800 Plus

Rapid CZE Analysis of Erythropoietin Variants

Heterogeneity analysis of cysteine-linked antibody-drug conjugate by CE method

Analyzing the Average Degree of Substitution of Betadex Sulfobutyl Ether Sodium by Capillary electrophoresis (Chinese)

Analysis of purity and isoelectric points of HPV by capillary electrophoresis (Chinese)

Determination of free carrier proteins in polysaccharideprotein conjugate vaccines by capillary micellar electrokinetic chromatography

CE-SDS-LIF方法对单抗药物的纯度分析(5-TAMRA标记)

SCIEX毛细管电泳在药典中的应用方案

Quantification of Whey Protein Content in Infant Formula by CE-SDS (Chinese)

Multi-Laboratory Validation for the Purity Analysis of Protein Products in CE-SDS Method Using CESI 8000 Plus (Chinese)

The Determination of α-lactalbumin and β-lactoglobulin in Dairy by Capillary Zone Electrophoresis (Chinese)

Purity Analysis of mRNA Vaccine by Using CGE-LIF (Chinese)

Comparation the N-Glycan of different sources recombinant human erythropoietin by using capillary electrophoresis with laser-induced fluorescence detector

The Determination of Lactoferrin in Dairy by Capillary Zone Electrophoresis (Chinese)

PA 800 Plus Empower Driver Notes de version

PA 800 Plus Empower Driver Versionshinweise

PA 800 Plus Empower Driver Notas de la versión

Size distribution analysis of residual host cell DNA fragments in lentivirus by CGE-LIF

High-precision lentivirus titer determination and protein profiling

Analysis of capping efficiency of mRNA by capillary gel electrophoresis

Size analysis of residual host cell DNA in Lentivirus by CGE-LIF

359_368_10337_2006_3_printpdf.pdf

Analysis of Poly A tail distribution of mRNA by capillary gel electrophoresis (Chinese)

PA 800 Plus Empower Driver 版本发布说明

PA 800 Plus Empower Driver リリースノート

PA 800 Plus Empower Driver Note di rilascio

PA 800 Plus Empower Driver Release Notes

RNA Kit

Specifications  
A66528 PA 800 Plus Pharmaceutical Analysis System Includes separation module with UV, photodiode array and LIF detection; system controller with PA 800 Plus software; system startup kit and reagents
A66527 PA 800S Plus Pharmaceutical Analysis System Includes separation module with photodiode array detection; system controller with PA 800 Plus software; system startup kit and reagents
Dimensions Height: 29.2 in (74.2 cm)
Door Open: 38.8 in (98.6 cm)
Width: 25 in (63.5 cm)
Depth: 28.4 in (72.1 cm)
Weight (uncrated) 188 lbs (85.3 kg) (includes photodiode array detection)
Electrical Requirements Voltage: 100 - 240 V; 50/60 Hz
Voltage Range 1 to 30 kV programmable at 0.1 kV increments
Current Range 3 to 300 μA programmable at 0.1 μA increments
Pressure Delivery Range -5 to +100 psi
Sample Temperature Control 4 - 60°C
Capillary Temperature Control 15 - 60°C
Sample Trays: 2 x 96-well plates 2 x 48 universal vials 2 x 48 0.2 mL microvials
Buffer Tray 2 x 36 universal vials
Detection Capability UV/Vis
200, 214, 254, 280 nm standard filter
190 - 600 nm (custom filter option)
Diode Array
190 - 600 nm (programmable)
0.5 - 32 Hz scan collection frequency (programmable)
Laser Induced Fluorescence (LIF)
300 - 700 nm excitation range
350 - 750 nm emission range
0 - 1000 RFU
Source Lasers with 3 mW Power Output 488 nm solid-state laser (included in A66528)
Learning Center  
Installing the LIF Aperture and Probe Guide/Stabilizer Step-by-Step Video Guide Watch
Cartridge Removal, Rebuild and Reinstallation Step-by-Step Video Guide Watch
Change the Coolant Tubing Step-by-Step Video Guide Watch
Change a Detector Step-by-Step Video Guide Watch
Capillary Removal Step-by-Step Video Guide Watch
Capillary Storage Step-by-Step Video Guide Watch
CE-SDS MW Application Guide Download
Glycan Analysis Application Guide Download
Fast Glycan Software Download
Sample Preparation for the Fast Glycan Technology on the PA 800 Plus Watch
Fast Glycan Sequencing Using a Fully Automated Carbohydrate Sequencer Download