AB Sciex is doing business as SCIEX. © 2010-2018 AB Sciex. The trademarks mentioned herein are the property of the AB Sciex Pte. Ltd. or their respective owners. AB SCIEX™ is being used under license. Beckman Coulter® is being used under license. Product(s) may not be available in all countries. For information on availability, please contact your local representative. For research use only. Not for use in diagnostic procedures.
PA 800 plus Pharmaceutical Analysis System

PA 800 plus Pharmaceutical Analysis System

PA 800 plus Pharmaceutical Analysis System

PA 800 plus Pharmaceutical Analysis System

PA 800 plus Pharmaceutical Analysis System

PA 800 plus Pharmaceutical Analysis System

PA 800 plus Pharmaceutical Analysis System

PA 800 plus Pharmaceutical Analysis System

PA 800 plus Pharmaceutical Analysis System
PA 800 plus Pharmaceutical Analysis System
PA 800 plus Pharmaceutical Analysis System
PA 800 plus Pharmaceutical Analysis System

PA 800 Plus Pharmaceutical Analysis System

For research use only. Not for use in diagnostic procedures.

Automated and Quantitative Analysis of Biologics

The PA 800 Plus is a robust analytical platform that provides characterization of product purity, charge heterogeneity and glycan analysis, to help you with the development and quality control of therapeutic proteins.

Intelligent features to enhance your operational efficiency:

  • The ease of ready-to-use cartridges plus the flexibility of custom method development expands your testing capabilities
  • Circulating Liquid Sample temperature control helps to maintain assay reproducibility
  • Automated methods and extended sample-handling capability allow walkaway operation
  • Versatile modular detection capability delivers real-time analysis with high precision for a variety of assays
  • Optimize and Lock down methods in Analytical Development for routine use in QA/QC

See the resources section below for webinars, videos, brochures, tech notes and manuals.

To find out how the PA 800 Plus can help you, request your samples to be analyzed now.

Request a Quote
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Characterize Therapeutic Proteins with Confidence
on the PA 800 Plus

Perform Consistent, and Compliant Biotherapeutics Characterization Faster than Ever

Variations in biotherapeutics affect the safety and efficacy of patient treatment and the reputation of your organization. With the PA 800 Plus Pharmaceutical Analysis System, you can confidently safeguard the success of your biologics. Run multiple characterizations from a single system that biopharma labs depend on, and produce qualitative and quantitative analyses, with speed and confidence.

The PA 800 Plus Pharmaceutical Analysis System is a robust analytical platform that provides characterization of product purity, charge heterogeneity, and glycan analysis, to help you with the development and quality control of therapeutic proteins.

You can do ALL this on the PA 800 Plus

  • Monoclonal Antibodies
    • Purity/Heterogeneity with Gold Standard CE-SDS in < 18 minutes
    • Glycan Analysis with award-winning Fast Glycan Technology
    • Charge Heterogeneity with simple and fast CZE or with hi-res cIEF
  • Peptides and Proteins beyond mAbs
  • Plasmids and Nucleic Acid Therapeutics – high-resolution and quantitative
  • Other biotherapeutics

Multiple Biotherapeutic Characterizations on ONE Platform

Biologics Characterization Results You Can Trust

Characterize molecules, large or small, with industry and regulatory compliant capillary electrophoresis (CE) technology. It’s why every biopharmaceutical company with therapeutic IgGs currently on the market uses SCIEX CE systems in their bioanalytical processes.

Trusted, Fast and Accurate Biotherapeutic Characterization

You Can Do ALL This on Your PA 800 Plus

Run Glycans up to 5x Faster than HILIC

Related Products

Resources and Support

RUO-MKT-18-5205-D
For research use only. Not for use in diagnostic procedures.

Resources
Filter by Type:

Title Date
Method Optimization and Evaluation for RNA Purity Analysis Using CE-LIF Technology 09/10/2018
IgG Purity-Heterogeneity and SDS-MW Assays with 96-Well Plate Adaption 08/01/2018
Better Characterize Your New Biologics with Robust Hi-Res Charge Het 07/19/2018
Assessing Glycosimilarity of Biotherapeutics 06/27/2018
Characterization of the Fc domain N-glycosylation in mAb and fusion protein therapeutics by CGE-LIF vs UPLC-FL 06/27/2018
High Throughput Off Platform Biopharma Method Development Using 96 Well Plate Format and CE-SDS 06/01/2018
PA 800 plus Pharmaceutical Analysis System Brochure 05/09/2018
A Single Analytical Platform for Glycan Analysis, Charge Heterogeneity, and Purity Determination of the NISTmAb 05/04/2018
The Importance of Temperature Control in Capillary Electrophoresis of Carbohydrates 04/30/2018
Clinical IVD LC-MS-MS Systems 04/10/2018
SDS-MW Analysis Kit for PA800-Application Guide 04/01/2018
Carbohydrate Labeling and Analysis Kit for PA800-Application Guide 04/01/2018
Innovations in Glycan Analysis on the PA 800 Plus, LC-MS and CESI-MS 03/10/2018
Purity, Identity, Heterogeneity Solutions Guide 03/10/2018
PA 800 plus Pre-Installation Guide 03/01/2018
IgG Purity and Heterogeneity Assay Kit for PA800 03/01/2018
Achieving Robust cIEF Analysis of Monoclonal Antibodies While Increasing Capillary Run-Life and Maintaining High Resolution and Reproducibility 03/01/2018
PA 800 plus cIEF Application Guide 02/01/2018
PA 800 plus Software Validation Pack 02/01/2018
Robust cIEF Method: Intermediate Precision for the pH 5-7 Range 01/05/2018
Assay of IgG Purity and Heterogeneity Using High-Resolution Sodium Dodecyl Sulfate Capillary Gel Electrophoresis (AIB A-1973) 01/05/2018
Capillary Electrophoresis in Quality Control: Part I: Application for Therapeutic Proteins 01/05/2018
Capillary Electrophoresis in Quality Control: Part II: CE-SDS: Method Development and Robustness 01/05/2018
SCIEX Fast Glycan Labeling and Analysis Technology 01/05/2018
PA 800 plus System Administrators Guide 01/01/2018
Holistic Approach to Understanding cIEF 12/28/2017
Capillary Electrophoresis with Indirect Ultraviolet Detection for Pharmaceutical Counterion Analysis 12/28/2017
High-Resolution cIEF of Therapeutic Monoclonal Antibodies: A Platform Method Covering pH 4-10 (AIB A-12026) 11/28/2017
Identification of System Parameters Critical for High-Performance cIEF (AIB A-11634) 11/28/2017
Automation of PA 800 plus CE-SDS Assays (IB-18278) 11/25/2017
Fast Glycan Sequencing Using a Fully Automated Carbohydrate Sequencer 09/14/2017
PA 800 Plus Carbohydrate Labeling and Analysis Guide 09/08/2017
Automated and Quantitative Analysis of Biologics with PA 800 Plus Pharmaceutical System 08/01/2017
mAb Characterization-Purity, Charge Heterogeneity and Glycan Analysis on a Single Platform Technology 06/22/2017
Sample Preparation for the Fast Glycan Technology on the PA 800 Plus 06/15/2017
Fast Glycan Labeling and Analysis Kit Application Guide 06/12/2017
CE Installation Qualification Guide 05/01/2017
Intercompany Collabration 03/29/2017
Complementary Study of the N-linked Glycosylation Profiling of a Therapeutic Glycoprotein 01/31/2017
Quantitative Results for N-Glycan, CE-SDS and Charge Heterogeneity Applications 10/19/2016
Separations Part Number Catalog 08/01/2016
Charge Heterogeneity Analysis of Biologics by High Resolution cIEF and High Throughput CZE Methods 06/29/2016
Automated and Quantitative Analysis of Biologics using the PA 800 Plus Pharma 04/12/2016
PA 800 Installing the Cartridge Aperture 04/07/2016
Installing the LIF Aperture and Probe Guide/Stabilizer 04/01/2016
PA 800 Installing the LIF detector 04/01/2016
PA 800 Trimming a Capillary 04/01/2016
PA 800 Uninstalling the LIF detector 04/01/2016
Biopharma CE Method Compliance in a Global Market 03/23/2016
Fully Automated One Hour Sample Preparation for Ultrafast N-Glycosylation Analysis of Antibody Therapeutics 03/10/2016
Capillary Storage 03/01/2016
PA 800 Cartridge Installation 03/01/2016
Removing the Ejector and Electrode on the PA 800 plus and PA 800 Enhanced 03/01/2016
Replacing the Ejector and Electrode on the PA 800 plus and PA 800 Enhanced 03/01/2016
PA 800 Cartridge Removal 02/01/2016
mAb charge heterogeneity analysis by CZE Part 3: A Test Method Fit for QC Testing 07/02/2015
mAb charge heterogeneity analysis by CZE Part 2: A case Study from Merck Sharp and Dohme 06/30/2015
mAb Charge Heterogeneity Analysis by CZE Part 1 Results of an Intercompany Robustness Study 06/18/2015
P-101-T New Methodology to Rapidly Identify Responders During Infliximab Treatment in Inflammatory Diseases 01/28/2015
P217W Fully Automated Sample Preparation with Ultrafast N-Glycosylation Analysis of Therapeutic Antibodies 01/28/2015
Sample preparation of mAb N-glycans using Magnetic Bead Technology and CE-LIF 11/25/2014
Purity Analysis of Bispecific Antibodies by Affinity Capillary Electrophoresis 10/02/2014
Characterizing Biologics Virtual Workshop 09/23/2014
Characterizing Biologics Virtual Workshop 09/23/2014
Cartridge Installation 05/09/2014
Cartridge Removal 05/09/2014
Cartridge Removal, Rebuild and Reinstallation 05/09/2014
Changing a Detector 05/09/2014
PA 800 Capillary Removal 05/09/2014
PA800 Cartridge Changing the Coolant Tubing 05/09/2014
PA 800 Removing the Ejector and Electrode on the PA 800 plus and PA 800 Enhanced 05/09/2014
Rapid Characterization & Assessment of Candidate Biosimilars Part 1 04/07/2014
PA 800 plus Maintenance Guide 01/08/2014
PA 800 plus Methods Development Guide 01/01/2014
Automation of CE-SDS Sample Preparation for PA 800 plus CE-SDS Assays 01/01/2014
PA 800 plus Pharmaceutical Analysis System User's Guide 01/01/2014
What Pesticides Have You Eaten Today 05/02/2012
PA 800 Change a Detector 11/03/2011
PA 800 Changing the Coolant Tubing 11/03/2011
PA 800 Cartridge Removal Rebuild and Reinstallation 11/03/2011
PA 800 Installing the Cartridge Aperture 05/09/2009
Utilizing Capillary Electrophoresis in a Quality Control Environment 04/22/2009
Capillary Ion Electrophoresis in Drug Discovery
CE Theory and Applications in Biopharma
Characterizing Biologics Virtual Workshop
cIEF in BR&D Analytical Development Webinar
Consistent, Confident and Compliant mAb Purity Results
Database Assisted Capillary Electrophoresis for Analytical Glycomics
Robust CE Methods: A Biomolecule Intercompany Collaboration as a Tool to Understand Method Variability
Rapid Magnetic bead based Sample Preparation for Automated and High Throughput N-glycan Analysis of Theraputic Antibodies
Measuring the Capillary
PA 800 Capillary Stoage
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A66528 PA 800 Plus Pharmaceutical Analysis System Includes separation module with UV, photodiode array and LIF detection; system controller with PA 800 Plus software; system startup kit and reagents
A66527 PA 800S Plus Pharmaceutical Analysis System Includes separation module with photodiode array detection; system controller with PA 800 Plus software; system startup kit and reagents
Dimensions Height: 29.2 in (74.2 cm)
Door Open: 38.8 in (98.6 cm)
Width: 25 in (63.5 cm)
Depth: 28.4 in (72.1 cm)
Weight (uncrated) 188 lbs (85.3 kg) (includes photodiode array detection)
Electrical Requirements Voltage: 100 - 240 V; 50/60 Hz
Voltage Range 1 to 30 kV programmable at 0.1 kV increments
Current Range 3 to 300 μA programmable at 0.1 μA increments
Pressure Delivery Range -5 to +100 psi
Sample Temperature Control 4 - 60°C
Capillary Temperature Control 15 - 60°C
Sample Trays: 2 x 96-well plates 2 x 48 universal vials 2 x 48 0.2 mL microvials
Buffer Tray 2 x 36 universal vials
Detection Capability UV/Vis
200, 214, 254, 280 nm standard filter
190 - 600 nm (custom filter option)
Diode Array
190 - 600 nm (programmable)
0.5 - 32 Hz scan collection frequency (programmable)
Laser Induced Fluorescence (LIF)
300 - 700 nm excitation range
350 - 750 nm emission range
0 - 1000 RFU
Source Lasers with 3 mW Power Output 488 nm solid-state laser (included in A66528)

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Industry and Regulatory Proven CE Technology

The PA 800 Plus Pharmaceutical Analysis System is a robust analytical platform so you can have confidence in your data, without sacrificing speed.

Fast Glycan Sample Preparation

Increase Efficiency

Running multiple assays on one platform simplifies staff training, maximizes ROI and reduces laboratory footprint.

Read More
C100HT System Set-up in Minutes

Trust Your Assays

Extensive intercompany studies demonstrate the robustness of SCIEX capillary electrophoresis assays, encompassing CE-SDS, cIEF, CZE, and glycan analysis.

Read More
SelexION Technology

Simplify Compliance

The USP has included validated procedures and system suitability criteria for IgG Purity and heterogeneity analysis by capillary electrophoresis.

Read More
SelexION Technology

Maximize Sensitivity

Achieve as low as 0.01% impurity detection, with at least three orders of magnitude of impurity, with modular detection (UV, PDA, LIF)

Read More
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Kit-based Assays

Get the reagents you need to run your experiments with one of the broadest selections of kit-based assays.

Learn More
SWATH® Acquisition

EZ-CE Cartridge

The convenient EZ-CE cartridge is ready-to-use across multiple applications.

Learn More
SelexION Technology

Connect to a Mass Spec

Integrate CE with electrospray ionization (ESI) and connect to a mass spec with the CESI 8000 Plus.

Learn More
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Automated and Quantitative Analysis of Biotherapeutics

Generate highly reproducible data with PA 800 Plus quantitative and automated solutions. Our engineers have collaborated closely with biopharma development and QC groups experienced in biologics characterization to create assays that address your analytical challenges.

Protein Purity Analysis

Quantitative Protein Purity Analysis with SDS-Gel Capillary Electrophoresis

Learn More

Glycan Analysis

Run glycans up to 5x faster than HILIC with simplified sample preparation, rapid, high-resolution separations, and automated glycan identification.

Learn More

Charge Heterogeneity

Conduct advanced capillary isoelectric focusing (cIEF) and hi-speed capillary zone electrophoresis (CZE) for charge heterogeneity analysis

Learn More

Peptide/Protein Characterization

Analyze peptide and protein biotherapeutics beyond mAbs.

Learn More

Plasmid/Nucleic Acid Analysis

Includes sensitive and effective techniques for nucleic acid purity, heterogeneity and sizing analyses

Learn More
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Learning Center

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Transferability

Develop and lock-down methods applicable to QC or regulated environments. Easily transfer methods using robust, automated assays with proven portability. Perfect for the global multi-user and multi-instrument organizations.

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EZ-CE Cartridge

The convenient EZ-CE cartridge is ready-to-use across multiple applications. Enhance data consistency and minimize staff training with the PA 800 Plus EZ-CE cartridge.

Learn More
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1. Multiple Applications, One Platform

Run multiple protein characterizations from a single system to improve your operational efficiency and effectiveness.

2. Raw Unmanipulated Data

Have the confidence critical to both you and regulatory agencies for product submission and commercialization with raw, unmanipulated data.

C100HT
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3. Reproducibility Matters

Get repeatable results with exclusive recirculating liquid coolant to control separation temperature precisely.

4. Portability Matters

Easily transfer methods using robust, automated assays with proven portability ‐ ideal for global multi-user, multi-instrument

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PA 800

Watch Video

Glycoprotein to Identified Glycans within
Record 90 minutes

SCIEX Fast Glycan Labeling and Analysis delivers rapid glycan heterogeneity identification, capable of profiling your glycans in record time. Read all about our Fast Glycan Technology.

Video Length 0:53

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Watch Video

mAb charge heterogeneity analysis by CZE

7/2/2015

Part 3: A Test Method Fit for QC Testing

Purity, Charge Heterogeneity and Glycan Analysis on a Single Platform

6/22/2017

High Thru-put CE-SDS Method for Challenging Therapeutics

6/1/2018

ADC calculations made easy by CE

4/16/2018

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AB Sciex is doing business as SCIEX. © 2010-2018 AB Sciex. The trademarks mentioned herein are the property of the AB Sciex Pte. Ltd. or their respective owners. AB SCIEX™ is being used under license. Beckman Coulter® is being used under license. Product(s) may not be available in all countries. For information on availability, please contact your local representative. For research use only. Not for use in diagnostic procedures.