The ZenoTOF 8600 system is designed to deliver reproducible, interpretable data across demanding workflows, helping scientists evaluate performance with evidence as studies evolve and scale.
ZenoTOF 8600 system
Unlock the proof that powers extraordinary discoveries
- Designed for reproducible, interpretable data as studies scale
- Supports proteomics, metabolomics, lipidomics, quantitation, Met ID, biopharma, and screening
- Software‑driven capability designed to evolve without disrupting workflows
- Evidence and data available for hands‑on evaluation
Confidence when it counts
Designed for real-world analytical pressure
As studies grow in size and complexity, analytical confidence depends on data quality that holds across changing conditions. The ZenoTOF 8600 system is designed to support dependable identification, quantitation, and characterization data today while supporting workflows as they evolve.
Built for confidence at scale
Confident discovery at scale
Designed to support reliable interpretation of low-abundance proteins and metabolites as studies grow and scientific questions evolve.
Robust quantitation across demanding workflows
Combines sensitivity, acquisition speed, and quantitative precision to support rigor and reproducibility beyond individual experiments.
Rigorous structural characterization
Delivers rich, high-quality MS/MS using versatile fragmentation approaches to support confident characterization of drug metabolites, lipids, and complex molecules across workflows.
A platform designed to adapt
Software-delivered advances are intended to expand capability without disrupting established workflows or data continuity.
For scientists who demand evidence, not promises.
Unlock the proof that powers extraordinary discoveries with real data, real workflows, and inspectable evidence
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See for yourself: access real data, real workflows, and evidence you can inspect.
Access the data files
Discover recorded presentations from leading scientists covering real workflows, method choices, and outcomes.
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Demand more than protein identification
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"The ZenoTOF 8600 system's flexibility to move between DIA, DDA, and PRM [or MRM] acquisition modes, combined with EAD fragmentation for applications inaccessible to collision-based dissociation alone, consolidates capabilities that previously required multiple platforms."
Matthias Mann Professor, Max Planck Institute of Biochemistry
Designed to protect data quality under demanding conditions
Mass Guard technology with an optical detector is designed to support operation at higher ion currents while helping protect the system from contamination
Flexible ionization across LC flow regimes
The OptiFlow Pro ion source is designed for flexibility when switching between nano-, micro-, and analytical-flow regimes, supporting a range of experimental strategies.
High-speed DIA, designed to improve selectivity at scale
ZT Scan DIA 3.0 supports scan speeds up to 1342 Hz, enabling narrow, continuously sliding isolation windows to improve precursor selectivity while maintaining dense MS/MS.
Fragmentation options for structural confidence
High-energy electron-activated dissociation (EAD) enables acquisition of high-quality spectra on timescales comparable to CID, enabling confident structural interpretation of lipids, metabolites, and protein modifications.
Sensitivity options for low-abundance features
The Zeno trap operation accumulates ions before pulsing them into the TOF, enabling confident analysis of low-level signals.
Designed to evolve with your science
Flexible front-end options, acquisition modes, and processing solutions enable researchers to adapt their methods to evolving experimental needs while maintaining data quality.
The proof to confidently assign biological significance across the metabolome
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“The ZenoTOF 8600 enhances significantly our capacity to detect and identify metabolites, to find things that matter, and to understand mechanisms.”
Nicola Zamboni Adjunct Professor, Inst. of Molecular Systems Biology, ETH Zurich
Confidence across workflows
The ZenoTOF 8600 system is a QTOF platform designed to support confident discovery, robust quantitation, and rigorous molecular characterization across demanding workflows. It emphasizes reproducible, interpretable data as studies scale, with capabilities intended to remain reliable as conditions change. The platform supports proteomics, metabolomics, lipidomics, Met ID, biopharma characterization, and high-throughput screening, with software-delivered advances designed to expand capability over time.
Proteomics demands depth, throughput, and quantitative reliability—often simultaneously. The ZenoTOF 8600 system supports discovery, quantitative, structural, and targeted proteomics on a single platform, designed to deliver consistent performance in real-world research environments.
Common use cases
- Discovery proteomics using DIA workflows where depth and quantitative reproducibility must scale across large cohorts
- Quantitative proteomics for longitudinal or population‑scale studies requiring consistent performance over time
- Low‑input and sensitivity‑driven proteomics where confidence in low‑abundance measurements is critical
- PTM, glycoproteomics, and structural proteomics workflows requiring rich, interpretable MS/MS for confident localization and characterization
- Targeted and hybrid discovery‑to‑validation proteomics on a single platform
Breaking down the metabolome requires unambiguous, interpretable data. The ZenoTOF 8600 system is designed to reduce uncertainty from the moment data are acquired, supporting confident annotation and defensible biological interpretation as datasets scale.
Common use cases
- Untargeted metabolomics profiling where confident annotation and reduced MS/MS ambiguity are required
- Targeted quantitative metabolomics in complex biological matrices, including low‑abundance metabolites
- Large‑cohort metabolomics studies where reproducibility and comparability across runs are essential
- Structural confirmation of metabolites and pathway intermediates using complementary fragmentation
- Studies transitioning from discovery to biologically defensible interpretation
Lipid structures can be fragile and isomeric. The ZenoTOF 8600 system supports comprehensive MS/MS and structural confirmation workflows designed to enhance interpretability, where subtle structural differences drive biological meaning.
Common use cases
- Untargeted lipidomics requiring confident differentiation of isomeric and isobaric species
- Structural lipid characterization where subtle positional or compositional differences drive biological meaning
- Quantitative lipidomics workflows demanding reproducibility across cohorts and conditions
- Studies combining coverage and structural confidence without reliance on extreme chromatography
- Integration of lipidomics into multi‑omics studies requiring consistent data quality
Quantitative needs range from optimized targeted assays to fully untargeted experiments. The ZenoTOF 8600 system supports multiple acquisition approaches designed to deliver reliable quantitation across varying study designs, sample types, and throughput requirements.
Common use cases
- Targeted quantitative assays for small molecules or peptides where sensitivity and precision are required
- Untargeted quantitative workflows where MS/MS‑level confidence supports reliable quantitation
- Quantitative studies spanning discovery through validation without changing platforms
- High‑throughput quantitative analysis requiring stable performance across varying sample loads
- Longitudinal or regulated‑adjacent studies where reproducibility under real‑world conditions matters
Metabolite identification often requires more than accurate mass. The ZenoTOF 8600 system supports rich MS/MS for structural clarity and confident tracking of low-abundance metabolites in complex matrices, helping strengthen confidence in identification and biotransformation interpretation.
Common use cases
- Drug metabolite identification requiring confident detection and structural characterization of low‑level species
- Biotransformation studies where minor modifications must be localized with high certainty
- Met ID workflows in complex matrices where rich MS/MS reduces reliance on assumptions
- Studies supporting regulatory decision‑making that require defensible metabolite characterization
- Extension of Met ID into higher‑throughput regimes without sacrificing interpretability
Biotherapeutic characterization requires rigorous, interpretable analysis across multiple levels of detail. The ZenoTOF 8600 system supports intact and aggregation analyses, peptide mapping, subunit workflows, and deeper structural approaches, enabling comprehensive characterization on a single platform.
Common use cases
- Intact and native mass analysis for assessment of mass, heterogeneity, and aggregation
- Peptide mapping workflows focused on confirmation and sequence integrity
- Subunit and middle‑down characterization to extend structural insight beyond peptide‑level analysis
- Higher‑order and conformational studies supporting comparability and structural understanding
- Multi‑stage biotherapeutic characterization on a single platform without workflow disruption
High-throughput screening requires speed without compromising analytical reliability. When paired with acoustic sampling workflows, the ZenoTOF 8600 platform is designed to support rapid sample introduction while maintaining interpretable mass spectrometry performance.
Common use cases
- High‑throughput screening workflows requiring speed without compromising data quality
- Intact protein screening where signal quality and reproducibility are critical across large sample sets
- Limited‑sample or precious‑sample studies benefiting from low sample consumption
- Early‑stage screening workflows that need interpretable mass spectrometry data at scale
- Expansion of screening capacity without changing analytical platforms
Designed to evolve with your science
Scientific workflows evolve faster than instrument replacement cycles. The ZenoTOF 8600 platform is designed to strengthen over time through software updates, workflow flexibility, and ecosystem compatibility—so new capabilities can be added without disrupting established methods or data continuity.
Powered by SCIEX OS software
SCIEX OS software provides a unified environment for acquisition, monitoring, and data handling across workflows. It is designed to support consistent performance over time by enabling system monitoring, automated tuning, and streamlined operation, helping maintain data quality as studies scale and conditions change.
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Software‑driven gains in selectivity, reproducibility, and scale
ZT Scan DIA demonstrates how software‑delivered capability can strengthen analytical performance on the same trusted platform. Iterative advancements are designed to improve precursor selectivity while maintaining dense MS/MS sampling, supporting reproducible quantitation and confident interpretation in complex datasets. By using an acquisition strategy rather than a hardware change, ZT Scan DIA enables workflows to evolve while keeping methods consistent and studies comparable.
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Front‑end solutions with the flexibility to support how science is done
The ZenoTOF 8600 system is designed to support a range of front‑end solutions, enabling researchers to adapt experimental strategies as scientific questions change. Flexible ionization, sampling, and workflow configurations enable users to transition among sensitivity‑driven studies, higher‑throughput analyses, and structural workflows without compromising analytical rigor. This flexibility helps extend the platform's useful lifetime, supporting new applications and study designs on the same core system.
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Third‑party software compatibility, for the freedom to work with the tools you trust
Modern research environments rely on diverse software ecosystems. The ZenoTOF 8600 platform is designed to support data access and compatibility with third‑party software tools, enabling collaboration, transparency, and continuity across analysis pipelines. This openness allows teams to integrate the system into existing workflows, apply preferred analysis approaches, and share data confidently across collaborators and partners—supporting evidence‑based decisions rather than isolated results.
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Designed to reduce operational impact without compromising performance
Operational efficiency matters in real labs, where systems run continuously, datasets grow quickly, and uptime directly affects productivity. The ZenoTOF 8600 system is designed to support efficient operation across energy use, data handling, serviceability, and long‑term support, helping reduce friction as studies scale. These considerations matter most in labs that run long acquisition schedules, work with large cohorts, and share infrastructure.
More energy efficient
The ZenoTOF 8600 system uses dry roughing pumps, which can reduce electricity consumption by up to 24% compared to oil‑sealed pumps under typical operating conditions. By eliminating oil handling and associated maintenance, dry pumps also help reduce routine intervention while supporting stable, day‑to‑day operation. For labs running long acquisition schedules or multiple systems, these efficiencies can translate into lower operational overhead without compromising analytical performance.
Computer and data storage efficiency
As studies scale, data volume becomes a practical constraint. The ZenoTOF 8600 platform is designed to support efficient data handling and storage strategies, enabling laboratories to manage large datasets generated by high‑throughput and cohort‑scale workflows. Compatibility with modern data infrastructure and flexible data access supports long‑term storage, reanalysis, and collaboration—helping ensure that data remains usable and accessible as scientific questions evolve.
Serviceability
The system is designed with serviceability in mind, helping minimize disruption during routine maintenance and system optimization. Design choices that support stable operation under demanding conditions help reduce unexpected downtime, supporting continuity in large or time‑sensitive studies. This focus on serviceability is intended to help laboratories maintain consistent performance over extended use, rather than optimizing only for short‑term benchmarks.
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Support
Ongoing support plays a critical role in long‑term system value. Our support helps you maintain performance over time with application guidance, system optimization, and access to evolving workflow knowledge. This approach supports confident operation as workflows change, methods evolve, and analytical demands increase, helping ensure that operational efficiency extends beyond the instrument itself to the broader research environment.
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Resources
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Technical note
Achieve deep proteome coverage at high throughput with ZT Scan DIA 3.0
Maintain over 90% proteome depth while increasing throughput up to 8× across large cohort studies.
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Technical note
Improve protein identification and quantitation precision with ultra‑selective DIA
Increase protein identification and quantifiable coverage with narrower Q1 windows and reduced MS/MS interference.
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Technical note
Enhance LFQ accuracy and proteome depth with narrow‑window scanning DIA
Achieve deeper coverage and more accurate quantitation with up to 39% more precursors identified in complex samples.
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Technical note
Improve metabolite identification and quantitation with narrow-window ZT Scan DIA 3.0
Learn how ~0.9 Da Q1 deconvolution reduces chimeric spectra and delivers broader metabolite coverage with more confident MS/MS-level quantitation.