Intabio ZT System | SCIEX
Comprehensive characterization of proteoforms with icIEF-UV/MS
Intabio ZT system

Comprehensive charge variant analysis made simple

The Intabio ZT system couples icIEF separation and UV detection with high-resolution mass spectrometry for peak identification.

Cut out risk, cut out information gaps.
Gain multiple pieces of critical data up front.

Accelerate candidate selection by achieving separation, quantitation, and direct identification of biopharmaceutical charge variants and their proteoforms with icIEF-UV/MS via the Intabio ZT system.

Collect the data for comprehensive charge variant ID in minutes not weeks.

Comprehensive proteoform identification in minutes

The process of identifying individual charge variant components and interpreting their structural differences conventionally takes weeks and requires the use of multiple instruments, with multiple manual steps.

With the Intabio ZT system - separation, quantitation and identification of individual charge variants can be achieved in minutes on a single platform.

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Request more information to learn how the Intabio ZT system can work for specific your needs.

Separation of charge variants with imaged capillary isoelectric focusing (icIEF) and quantitation with imaged UV detection occurs within the separation channel

To enable electrospray ionization, electrolyte is introduced through the mobilizer channel near the ESI tip, to re-ionize the charge variants. The electric field is re-oriented to initiate the mobilization of the peaks toward the electrospray “ESI” tip. This novel chemical mobilization process ensures that peak resolution is maintained throughout MS detection.

Separated charge variants are introduced to the mass spectrometer by electrospray ionization for peak identification.

Eliminate the guess work with the ZenoTOF 7600 system

Enable a more detailed characterization approach by leveraging the enhanced capabilities of the powerful ZenoTOF 7600 system with EAD fragmentation technology.

Guide decisions with multidimensional analysis using the Intabio ZT system

Contact SCIEX
Request more information to learn how the Intabio ZT system can work for specific your needs.

Wherever you play in the pipeline, change the game in modern medicine

Clone selection, cell line development

Intact protein analysis, charge variant analysis, PTM characterization

Process development

Charge variants, glycoforms, PQA assessment

Formulation

Stability/degradation

Manufacturing attribute monitoring

CQA and PQA monitoring