Biologics Explorer software
Achieve clarity on your biotherapeutic
Leveraging the latest acquisition techniques and built on a heritage of proven performance, Biologics Explorer software delivers highly accurate and informative workflows for fully characterizing protein biotherapeutics. Reach decisions on the most important critical quality attributes for biopharmaceuticals faster and more confidently.
Wide variety of workflows
Biologics Explorer software supports the most important LC-MS characterization assays right out of the box, based on industry best practices. The intuitive nodal structure is easy to optimize so you can get exactly what you want from your assays. Available workflows include:
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01:
Intact protein and subunit analysis
Cut through the noise in real time to visualize what matters and interact with the answer directly. Biologics Explorer software provides one simple solution that delivers visual and written data for the characterization of intact protein therapeutics.
Heat maps and a 3D display provide a multi-dimensional view of data files to facilitate quick assessment of data quality and impurity level at the intact level.
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02:
Middle-down mAb fragment analysis
Perform comprehensive analysis of protein subunits, with templates optimized for biotherapeutic characterization. Achieve consistent high-sequence coverage, enable rapid method development and confident PTM localization with intuitive visual tools. Make decisions on candidate developability or product quality sooner.
Streamline method development and gain critical information quickly with simple visual tools for comparative analysis.
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03:
Peptide mapping
Maximize efficiency with pipeline specific workflow templates optimized based on needs:
- Quick and efficient peptide mapping for quality checks
- In-depth peptide mapping
- Detect unexpected modifications
- N-/O-glycan site specific mapping
- Isomer differentiation
Visualize sequence coverage and modifications in a single interactive viewing pane.
- Sequence coverage map with color coding to indicate modification type
- Identified peptides shown in table format
- See MS/MS information by selecting desired peptide
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04:
Disulfide bond and PTM determination
Enable comprehensive identification and spectra annotation of complex peptides with disulfide linkages.
Disulfide bond mapping using CID and EAD.
Visualize CID (A) and EAD (B) provide complementary results for a disulfide-linked peptide from the HC of T-DXd.
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05:
Multi-attribute methodology (MAM)
Reduce overall analytical testing burden with ready-to-use workflow templates. Enable confident peptide mapping results and visualization tools, with the ability to export product quality attribute (PQA) lists to compliance-ready SCIEX OS software for quantification and monitoring.
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06:
Intabio ZT system
Access multidimensional data from one integrated icIEF-UV/MS workflow. Within one layout simultaneously view UV electropherogram, results summary, MS data, deconvoluted ion map results and raw MS data to generate a single report for comprehensive overview of charge variants with peak identification.
Biologics Explorer software relates all the information for proteoform identification on one screen.
Visualizations provide insight
- Next generation biologics are becoming more complex with more potential post-translational modifications and protein forms. This produces a vast amount of digital information from mass spec characterization.
- With the use of intuitive visualizations, Biologics Explorer software gets you from sample to insight - fast! The software provides the ability to immediately see patterns and features even in raw data, ensuring you don't miss identifying anything important.
Built for EAD
- Electron activated dissociation (EAD) in the ZenoTOF 7600 system breaks new ground in depth of coverage for peptide mapping and PTM analysis of biopharmaceuticals. EAD produces incredibly rich MS/MS spectra.
- Biologics Explorer software is critical for transforming those rich spectra into incredibly informative results. The data processing engine is optimized to extract the maximum amount of information from every CID and EAD spectrum.
Transparency from start to report
- Unlike Biologics Explorer, biologics characterization in some applications can leave you wondering how exactly the result was reached. The data can go in, and an answer can come out, without any clarity around how it happened.
- Biologics Explorer software is all about transparency. The workflow-based setup allows you to see all the steps of what is happening with optimization at each node to get the best out of your data.
Powered by Genedata Expressionist®
- Biologics Explorer software is built upon an industry-leading platform for biopharmaceutical mass spectrometry. Leveraging the expert knowledge and proven capabilities of Genedata Expressionist®.
Biologics Explorer software is compatible with these featured systems below and across all SCIEX high resolution mass spectrometers:
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
A purpose-built QTOF system, designed specifically to accelerate everyday biologics characterization.
Eliminate the guess work and monitor biologics at the intact-protein level, gaining insights into charge variant-associated quality attributes.