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Whether you are involved in biopharma discovery, early development or late development, you need fast and dependable peptide mapping analysis techniques that you can count on.
In early development candidate selection, determining the appropriate critical quality attributes (CQA) is paramount and depends on extremely complex data processing and analysis. In late development, throughput is your top priority so you can process and analyze high sample volumes, quickly. Although the requirements of peptide mapping analyses change during the development pipeline, the need to store, access and share large data sets is consistent throughout.
With SCIEX mass spec solutions, you can now benefit from 100% sequence coverage in a single injection and see low level post-translational modifications – faster than ever before.
SCIEX combines cutting edge mass spec technology into an integrated solution designed specifically to address the challenges of peptide mapping at all stages of the therapeutic development pipeline.
Comprehensive Sequence Analysis with CESI-MS
Experience the orthogonal separation technique of CESI-MS, providing 100% sequence coverage with a single injection, from a single protease digestion.
Peptide Analysis Becomes Routine with the X500B QTOF
Simplify and accelerate peptide mapping workflows with the powerful and intuitive X500B QTOF system that eliminates complex method development by using a generic data-independent SWATH® Acquisition method for the analysis of all detectable peptides in a sample.
Answers at the Speed of Light
Eliminate time consuming manual data analysis, interpretation and reporting with revolutionary BioPharmaView™ Software. Process large batches, annotate the peptide sequence and report detailed quantitation information – it’s automated and accurate.
For research use only. Not for use in diagnostic procedures.
CESI-MS has exceptional separation efficiency for peptides (especially the very short or very long, or highly charged peptides) and glycopeptide mapping of mAbs. It can differentiate between Asp and IsoAsp deamidation and other PTMs, with the exceptional ability to provide 100% coverage from a single enzyme digestion in a single analysis.
The powerful X500B QTOF System combined with the intuitive SCIEX OS point-and-click icon based interface has revolutionized routine peptide analysis. Dramatically reducing the complexity of setting up LC-MS methods and batches, the system makes standardized peptide mapping analyses accessible to scientists of any skill level, without the involvement of mass spec experts. The use of SWATH Acquisition, an unbiased data-independent acquisition strategy, requires no up-front method development but can provide comprehensive sample coverage for all detectable peptides in a single injection.
Now you can get faster answers to your peptide mapping questions with the powerful data processing capabilities of BioPharmaView Software. Combined with the accurate mass data from the X500B QTOF or TripleTOF® systems, it is a rapid and intuitive package for analyzing your peptide mapping data.
For Biopharma development labs that need to dostandardized peptide mapping analyses, the X500B QTOF System offers an easy-to-use platform that is accessible to all user levels.
Delivers high accuracy, reliability and repeatability across thousands of injections, with maximum uptime
High speed accurate mass analysis with the compact and streamlined QTOF System and the renowned Turbo V™ ionization source
Intuitive point-and-click acquisition software makes it easier than ever to set-up and run your methods
Automated biotherapeutic data processing for accurate peptide identification, including post-translation modifications
For labs that need to perform in-depth biotherapeutic characterization, the increased sensitivity provided by CESI high resolution CE separation and enhanced dynamic range of the TripleTOF 6600 system can help you get the advanced answers you need.
In-depth characterization of digested biologic product—especially short peptides, long hydrophobic peptides, drug-linked peptides, glycopeptides and deamidated peptides.
Maximal sensitivity and broad linear quantitation range for large molecules, ideal for in-depth characterization and detection of low-level peptide species.
Technical Note: Comparative Peptide Mapping of trastuzumab
Technical Note: Automating Quantitation of Oxidation Sites in mAb Characterization
Solutions Guide: Peptide Mapping Analysis
Case Study: Peptide Mapping Case Study
Method Brief: Non-reduced Biotherapeutic Peptide Mapping
Method Brief: Biotherapeutic Peptide Mapping: IDA Method
Method Brief: Biotherapeutic Peptide Mapping: SWATH Acquisition Method
Technical Note: Rapid Characterization of Biologics using CESI and TripleTOF systems
Webinar: Multilevel Characterization of Biotherapeutics using CESI-MS: from intact to peptide mapping
Webinar: Intact Proteoform Characterization using CESI-MS
Webinar: CESI-MS for Biotherapeutic Characterization
Technical Note: Fast, Efficient Disulfide Bond Mapping Using BioPharmaView Software
Technical Note: Automated High-throughput Trypsin Digests for Peptide Mapping Analysis
Software Bulletin: BioPharmaView™ Software Bulletin
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