Technology innovation such as high-resolution accurate mass spectrometry has paved the way toward a comprehensive study of the exposome.
The exposome was introduced by C.P. Wild in 2005 as a concept for studying the relationship between chemical exposures and nonchemical factors (such as diet, lifestyle and social behaviors) and how these interact with the unique characteristics of humans (such as genetics, physiology and epigenetics) to impact our health. 1-3
This multi-disciplinary approach has been adopted by many research areas, including environmental epidemiology, health risk assessment and environmental and human biomonitoring.4-6 Traditional measurements of exposure include targeted monitoring and untargeted discovery of unknown chemicals.1,4 Exposomics takes this a step further to measure internal exposures, relying on metabolomics, lipidomics and proteomics to assess health and disease effects.
The exposome deals with thousands of environmental factors that vary by time, place and source. The most significant challenge for epidemiological research is that these factors fluctuate over a lifetime, changing due to aging, infections, lifestyle, stress, preexisting disease, psychosocial issues and other factors.7 Moreover, as with most omics-based studies, exposomics also needs you to analyze a wide range of molecules with varying chemical properties and a broad range of concentrations.
Clearly you need a characterization strategy that is effective for targeted and non-targeted screening and quantification.
High-throughput analysis using high-resolution accurate mass spectrometry
Expand the potential of your exposomics analysis with high-resolution accurate mass spectrometry. SCIEX high-resolution accurate mass spectrometry offers you specificity, sensitivity and reliability for your qualitative and quantitative environmental analyses, including targeted and non-targeted screening methods. Get ready to:
6-month study of the pesticide desphenyl-chloridazon in natural water
This easy-to-use accurate mass spectrometer system analyzes data faster using the power of SWATH® Acquisition.
This all-in-one software lets you acquire, process and analyze data, and even generate reports.
Employ the MRM sensitivity of a triple quadrupole system to get even better identification and quantification.
Access more 17,000 compounds available at the click of a button.
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Chemical profiling of accurate mass LC-MS/MS data to identify unexpected environmental pollutants | Download |