AB Sciex is doing business as SCIEX. © 2010-2019 AB Sciex. The trademarks mentioned herein are the property of the AB Sciex Pte. Ltd. or their respective owners. AB SCIEX™ is being used under license. Beckman Coulter® is being used under license. Product(s) may not be available in all countries. For information on availability, please contact your local representative. For research use only. Not for use in diagnostic procedures.
For research use only. Not for use in diagnostic procedures.
The QTRAP 4500 System takes the legendary 4000 QTRAP Platform and intelligently re-engineers it to set a new benchmark for reliable quantitation and library searching – with 100-fold more full-scan sensitivity over basic triple quadrupoles in the same class. The LC-MS/MS workhorse, intelligently re-engineered.
As one of the only triple quadrupole instruments with optional Linear Accelerator™ Trap technology, the QTRAP 4500 System enables powerful, unique workflows that deliver a new level of confidence in your data:
Whether your research is focused on ADME, regulated bioanalysis, food and environmental contaminant screening, targeted quantitative proteomics, or forensic toxicology, the QTRAP 4500 System covers your key performance criteria:
Known as the LC-MS/MS workhorse, this is the intelligently re-engineered design of the 4000 QTRAP Platform, and sets a new benchmark for robust quantitation and library searching.
The system is ideal for laboratories requiring ultimate robustness, ruggedness, and reliability for high-throughput screening of many compounds in many samples every day.
Check out how SCIEX customers are using the QTRAP 4500 System in these scientific publications.
Powered by BIOZ, the world's first search engine for life science experimentation. Their cloud platform combines the work of scientists with AI technologies to help life scientists make faster and smarter experimentation decisions.
These scientific articles are supplied by a third-party resource and have not been evaluated by SCIEX. Articles are provided as-is and without warranty of any kind, including intellectual property rights and reported issues.
|Mass Range||Up to 2000 Da|
|Features||Turbo V, Pulse Counting Detector|
|Detector Type||AcQuRate Pulse Counting Detector|
|Scan Types||Q1 MS, Q3 MS, Product Ion, Precursor Ion, Neutral Loss or Gain, MRM, EMS, EPI, ER, MS3, MRM3, TripleTrap Scanning|
|Ionization Sources||Turbo V; TurboIonSpray; Atmospheric-pressure chemical ionization (APCI); DuoSpray®, and NanoSpray® III, Phytronix LDTD, Advion LESA Clarity, Digital PicoView, NanoSource|
Unmatched, simultaneous quantitative and qualitative analysis
TripleTrap Scanning with QTRAP Technology: Unique to SCIEX mass spectrometry platforms, QTRAP Technology delivers a 100-fold increase in full-scan sensitivity over basic triple quadrupoles enhancing qualitative workflows while the advantage of simultaneous quantitation and library searching workflows.
High-confidence library searching and fast eQ Electronics for UHPLC: The 4500 Series uses proven eQ Electronics delivering polarity switching speeds of 50 msec and scan speeds of 20,000 Da/sec, creating a potent solution for detecting unexpected contaminants. Combined with a single comprehensive library of thousands of QTRAP Spectra for library matching, contaminants at the lowest levels can be confidently identified on a UHPLC time scale.
MRM3-enhanced selectivity: MRM3 workflows provide enhanced quantitative selectivity when high background or challenging co-eluting interferences make standard MRM quantitation difficult. This type of higher selectivity workflow can facilitate the quantitation of tryptic peptides in complex matrices and help avoid the need for labor-intensive chromatography methods.
Drive productivity: The Turbo V Source provides high-sensitivity analysis over a wide range of flow rates with quick-change atmostpheric-pressure chemical ionization (APCI) and TurboIonSpray Probes. With functional flow-rate ranges from 5 µl/min to 3 mL/min, the Turbo V Source is the perfect match for narrow bore, standard bore, micro flow and analytical flow UHPLC flow rates, delivering unmatched desolvation and stability for the most demanding applications.
Proven QJet® 2 Ion Guide – enhanced sensitivity and simplicity: The patented QJet 2 Ion Guide design yields improved ion containment and operates at higher pressures providing better collisional focusing to enhance ion transmission and increase sensitivity. The new design also reduces the gas load, allowing the turbo pump to run cooler in its ideal operating range. It all adds up to our most reliable LC-MS/MS workhorse ever – and with tool-free maintenance, routine cleanup of the QJet 2 Ion Guide can be accomplished within minutes.
Analyst Method Converter: SCIEX is conscious of the fact that customers must consider the impact of method transfers on resources, time-lines, and data quality. For this reason, SCIEX has created the Convert Methods Utility, an innovative tool that takes pre-developed Analyst MS-Methods established on the 3200, 4000, 5000 and even 5500 Platforms and updates them instantly for use with the 4500 Series for a seamless, accelerated integration.
|4500 QTRAP Lab Wall Branding||03/21/2019|
|Quantitation Analysis of Human Insulin-like Growth Factor I (IGF1) in Serum by Using SPE-LC-MS/MS Workflow||02/19/2019|
|Identification & Confirmation of Structurally Related Degradation Products of Simvastatin||01/07/2019|
|Parts and Equipment Guide for Ion Sources and Mass Spectrometers (EN)||12/31/2018|
|Parts and Equipment Guide for Ion Sources and Mass Spectrometers (DE)||12/31/2018|
|Parts and Equipment Guide for Ion Sources and Mass Spectrometers (ES)||12/31/2018|
|Parts and Equipment Guide for Ion Sources and Mass Spectrometers (FR)||12/31/2018|
|Parts and Equipment Guide for Ion Sources and Mass Spectrometers (IT)||12/31/2018|
|Parts and Equipment Guide for Ion Sources and Mass Spectrometers (JA)||12/31/2018|
|Parts and Equipment Guide for Ion Sources and Mass Spectrometers (ZH)||12/31/2018|
|Environmental Compendium Volume 3||12/10/2018|
|Highly Selective Bioanalytcal Quantitation Method for Analysis of (R)-Amlodapine and (S)-Amlodapine Enantiomers in Human Plasma using LC-MS/MS||12/06/2018|
|Powerful Scan Modes of QTRAP System Technology||11/27/2018|
|Resolution of Ether and Diacyl-Linked Phospholipids by Differential ION Mobility Spectrometry (DMS)||11/19/2018|
|Simultaneous Quantitation of Fat-Soluble Vitamins in Formula Infant Milk by LC-MSMS||11/17/2018|
|Quantitative Analysis of Fentanyl and Analogues in Human Whole Blood||10/24/2018|
|Quantitative and Qualitative Metabolomics for the Investigation of Intracellular Metabolism||10/22/2018|
|Confirmation of Pesticides in Jalapeno Peppers Using QTRAP MS-MS Data and Library Matching in SCIEX OS-Q||08/01/2018|
|Essential LC-MS Performance Kits||06/01/2018|
|User Guide: NanoSpray Ion Source Operator Guide (IT)||05/31/2018|
|User Guide: NanoSpray Ion Source Operator Guide (DE)||05/31/2018|
|User Guide: NanoSpray Ion Source Operator Guide (FR)||05/31/2018|
|User Guide: NanoSpray Ion Source Operator Guide (EN)||05/31/2018|
|LC-MS-MS Solution for Determination of Nitrosamine Disinfection byproducts in Drinking Water||05/20/2018|
|Analysis of PFAs in drinking water wEPA Method 537.1||05/01/2018|
|LC-MS-MS 101-What you always wanted to know||04/24/2018|
|Ion Source Tests, Specifications, and Data Log||03/10/2018|
|SCIEX QTRAP 4500 Mass Spectrometer Declaration of Conformance||02/09/2018|
|NanoSpray III Source and Heated Interface||02/07/2018|
|User Guide: Turbo V Ion Source Operator Guide (ES)||12/20/2017|
|User Guide: Turbo V Ion Source Operator Guide (PL)||12/20/2017|
|User Guide: Turbo V Ion Source Operator Guide (PT)||12/20/2017|
|Turbo V Ion Source Operator Guide (RU)||12/20/2017|
|Turbo V Ion Source Operator Guide (ZH)||12/20/2017|
|Turbo V Ion Source Operator Guide (JA)||12/20/2017|
|User Guide: Turbo V Ion Source Operator Guide (IT)||12/20/2017|
|User Guide: Turbo V Ion Source Operator Guide (FR)||12/20/2017|
|4500 Series of Instruments Site Planning Guide (North America/EMEA only)||12/20/2017|
|4500 Series of Instruments User Guide (DE)||12/20/2017|
|4500 Series of Instruments Site Planning Guide (DE)||12/20/2017|
|4500 Series of Instruments Qualified Maintenance Person Guide (DE)||12/20/2017|
|4500 Series of Instruments Qualified Maintenance Person Guide (ES)||12/20/2017|
|4500 Series of Instruments User Guide (ES)||12/20/2017|
|4500 Series of Instruments Qualified Maintenance Person Guide (FR)||12/20/2017|
|4500 Series of Instruments Site Planning Guide (FR)||12/20/2017|
|4500 Series of Instruments User Guide (FR)||12/20/2017|
|4500 Series of Instruments Qualified Maintenance Person Guide (IT)||12/20/2017|
|4500 Series of Instruments Site Planning Guide (IT)||12/20/2017|
|4500 Series of Instruments User Guide (IT)||12/20/2017|
|Expanding Suspect Screenig and Non-Targeted Identification||12/20/2017|
|Dont miss Synthetic Drug Present in Sample||12/20/2017|
|Over 17K Compounds Available-X500R and Spectral Libraries||12/10/2017|
|MRM3 Quantitation for Highest Selectivity in Complex Matrices||12/05/2017|
|Extending Metabolome Coverage-untargeted Metabolomic Workflows||12/05/2017|
|DuoSpray Ion Source for Triple Quadrupole and QTRAP Systems Operator Guide (DE)||10/10/2017|
|Turbo V Ion Source Operator Guide (DE)||10/10/2017|
|Turbo V Ion Source Operator Guide (EN)||10/10/2017|
|DuoSpray Ion Source for Triple Quadrupole and QTRAP Systems Operator Guide||10/01/2017|
|Assessing Ease of Method Transfer from the API 4000 System to the SCIEX Triple Quad 4500 System for the Quantification of Loratadine in Human Plasma||09/26/2017|
|Pesticides and potency in CANNABIS LC-MS-MS testing||08/08/2017|
|vMethod Application for Food Testing||07/25/2017|
|Screening and Speciation of Raw and Processed Meat Products||06/01/2017|
|Identification of the Metabolites of Tetrachloronamide by QTRAP 4500 Complex Mass Spectrometry System||06/01/2017|
|Cannabis for Per Se Law Testing in Whole Blood using theSCIEX Triple Quad QTRAP 4500 LC-MS/MS System||03/06/2017|
|Solution for Cannabis in Whole Blood Analysis||03/06/2017|
|QTRAP Compendium (JP)||01/10/2017|
|M3 MicroLC for TripleQuad-QTRAP Test and Data Log||12/10/2016|
|M3 MicroLC-TE for Triple Quad and QTRAP Test and Data Log||12/10/2016|
|High Selectivity Quantification of Protein Isoforms using MRM3 Workflow||12/01/2016|
|Throughput and Sample Preparation Improvements for Endocrine Research by Micro-flow LC-MS/MS||10/14/2016|
|LC-MS/MS Analysis of Emerging Food Contaminants (Beverages)||08/01/2016|
|Target and non-target water testing: claim and reality||07/27/2016|
|Screening for fungal and bacterial toxins using QTRAP® technology||07/12/2016|
|Automated glyphosate testing in water and food samples||07/07/2016|
|LC-MS/MS analysis of marker compounds for sensory quality and authenticity of fruit juices||05/16/2016|
|Qualitative and quantitative analysis of pesticides in food samples using the X500R QTOF System||05/11/2016|
|Solution for Food Allergen Screening||05/02/2016|
|Comprehensive Quantitation and Identification of Pesticides in Food Samples Using the SCIEX UltraLC 100 and the SCIEX QTRAP 4500 System||05/01/2016|
|Simultaneous analysis of 12 food allergens in baked and raw food products using the LC-MS/MS QTRAP 4500 system||05/01/2016|
|User Guide: 3500, 4500, and 6500+ Systems Electromagnetic Environment Information||04/20/2016|
|Rapid and Sensitive Analysis of a 93-Compound Forensic Panel in Urine||04/10/2016|
|4500 Series Brochure||03/15/2016|
|4500 Brochure - The Workhorse||03/01/2016|
|Fast and Simultaneous Analysis of Ethanol Metabolites and Barbiturates using QTRAP 4500 LC-MS/MS System||02/01/2016|
|SCIEX Defined Major Repairs||01/10/2016|
|Rapid and Sensitive Analysis of a 93-Compound Forensic Panel in Urine using the QTRAP/Triple Quad 4500 LC-MS/MS System||10/01/2015|
|User Guide: PhotoSpray Ion Source Operator Guide||09/16/2015|
|User Guide: DuoSpray Ion Source for Triple Quadrupole and QTRAP Systems Operator Guide (IT)||08/31/2015|
|User Guide: DuoSpray Ion Source for Triple Quadrupole and QTRAP Systems Operator Guide (FR)||08/31/2015|
|User Guide: PhotoSpray Ion Source Operator Guide (IT)||08/31/2015|
|User Guide: PhotoSpray Ion Source Operator Guide (DE)||08/31/2015|
|User Guide: PhotoSpray Ion Source Operator Guide (FR)||08/31/2015|
|User Guide: DuoSpray Ion Source for Triple Quadrupole and QTRAP Systems Operator Guide (ES)||08/31/2015|
|User Guide: PhotoSpray Ion Source Operator Guide (ES)||08/31/2015|
|Ultra-fast amino acid analysis using the SCIEX Triple Quad 4500 System and the SCIEX MicroLC 200 System with aTRAQ Reagent Technology||08/01/2015|
|Automated Sample Preparation for the Monitoring of Ethanol Metabolites in Urine by LC-MS/MS||07/31/2015|
|CYP4500 Protein Assay - Human Induction Kit Extended Panel||07/01/2015|
|Spectral Libraries for Food Analysis - Antibiotics||03/05/2015|
|Spectral Libraries for Food Analysis - Pesticides||03/05/2015|
|Automated Sample Preparation and Analysis Workflow for Mycotoxin Contamination in Different Food Matrices||09/01/2014|
|User Guide: SCIEX 4500 Series of Instruments Site Planning Guide||06/01/2014|
|User Guide: SCIEX 4500 Series Site Planning Guide (JA)||06/01/2014|
|QTRAP Functionality: Is it Useful to Toxicology Labs||06/01/2014|
|Using Your QTRAP LC/MS/MS System at Full Potential (Libraries)||01/01/2014|
|Are Pork Extracts Present in My Gummy Bears? Gelatin Speciation by LC-MS/MS||01/01/2014|
|Analysis of Propofol (2,6-Diisopropylphenol) and its Metabolites in One Injection using the DuoSpray™ Ion Source||01/01/2014|
|Identification and Quantitation of Designer Drugs in Urine by LC-MS/MS||01/01/2014|
|Prep-and-Shoot: Complete automation of the hydrolysis and analysis of forensic urine samples by LC-MS/MS||01/01/2014|
|The Use of Micro Flow LC Coupled to MS/MS in Veterinary Drug Residue Analysis||01/01/2014|
|Automated Sample Preparation and Analysis Workflows for Pesticide Residue Screening in Food Samples using DPX-QuEChERS||10/02/2013|
|Instrument Front-End Cleaning Procedure Manual||10/01/2013|
|Method Development for Fake Lamb Meat Detection using SCIEX QTRAP 4500 system (CH)||04/01/2013|
|4500 Series of Instruments System User Guide||04/01/2013|
|High Throughput Automated Sample Preparation and Analysis Workflow for Comprehensive Forensic Toxicology Screening using LC/MS/MS||03/12/2013|
|Automated Derivatization, SPE Cleanup and LC-MS/MS Determination of Gyphosate and Other Polar Pesticides||01/01/2013|
|Comprehensive Forensic Toxicology Screening in Serum using On-Line SPE LC-MS/MS||01/01/2013|
|Master Your Data to Get to the Answer, View Results with Ease and Confidence (targeted)||01/01/2013|
|Using Your QTRAP® LC/MS/MS System at Full Potential||01/01/2013|
|LC-MS/MS Analysis of Emerging Food Contaminants Quantitation and Identification Acrylamide in Starch-Rich Food||04/01/2012|
|The Use of Micro Flow UHPLC in Pesticide Screening of Food Samples by LC-MS/MS||04/01/2012|
|LC-MS/MS For Environmental Testing||03/01/2012|
|Rapid Quantitation and Identification of Carbendazim in Orange Juice Using the New SCIEX QTRAP 4500 LC/MS/ MS System||03/01/2012|
|User Guide: NanoSpray III Ion Source Consumables||01/01/2012|
|LC-MS/MS Analysis of Water using the Eksigent ekspert microLC 200 and SCIEX QTRAP 4500||01/01/2012|
|Quantitative LC-MS/MS Combining Confident Identification with Scheduled MRM, Fast Polarity Switching, UHPLC Time Scales||01/01/2012|
|Simple LC-MS/MS Screening and Quantification Methods for the Analysis of 41 Common Pain Drugs in an Oral Fluid Matrix||01/01/2012|
|Introducing the SCIEX QTRAP 5500 LC-MS/MS System||10/05/2010|
|Higher Confidence in Identification with QTRAP LC/MS/MS Systems when Screening and Quantifying Pesticides in Fruit and Vegetable Samples||03/01/2010|
|User Guide: NanoSpray Head and Emitter Tip Assembly Quick Start Guide|
|MassSpectator - Food Safety Edition|
Triple quadrupole: 5 – 2,000 Da
Linear ion trap: 50 - 2,000 Da
Options include Electrospray (ESI) ionization and heated nebulizer ionization probes.
50 msec in MRM and Scheduled MRM modes
AcQuRate Pulse Counting CEM
Maximize uptime with a system that can handle even the most difficult matrices with ease. Includes legendary Turbo V™ technology, patented QJet® Ion Guide design, and the ultimate Pulse Counting detector.
This legendary source provides high-sensitivity analysis over a wide range of flow rates with quick-change APCI and TurboIonSpray® probes.
The patented design yields excellent ion containment and operates at high pressure, providing better collisional focusing to enhance ion transmission for ultimate sensitivity.
The detector technology works in combination with a pulse overlap correction algorithm, enabling more accurate and precise ion detection over a wide dynamic range.
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