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The Power of Precision
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Advance your research with front-end instruments designed to help you realize the full power of your mass spectrometer. SCIEX has the broadest portfolio of ESI-MS front-ends that can facilitate various flow rates, sample requirements and sensitivities. No one else offers the entire range of analytical flow, microflow, nanoflow LC-MS and even ultra-low flow CESI-MS.
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Differential mobility spectrometry (DMS) and ion mobility spectrometry are analytical techniques used to separate ions based on their gas phase mobility. Multiple types of ion mobility devices exist, such as drift tubes, traveling wave, and high-field asymmetric waveform devices. Learn how you can separate yourself with Differential Ion Mobility.
The latest ion sources from SCIEX enable enhanced sensitivity and robustness with greater desolvation range across all MS platforms, from Triple Quad to QTRAP and QTOF.
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vMethod applications are pre-configured and verified LC-MS/MS methods that reduce the need for method development – significantly cutting the time, effort and money to deploy a new assay. Every vMethod provides method conditions, recommended sample prep, LC and MS conditions, and details for applicable MS/MS library databases for key applications.
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High resolution and QTRAP libraries can dramatically enhance the quality of your analysis, giving you much improved confidence in your data. With a comprehensive library at your fingertips, you can easily create methods and process targeted and non-targeted screening data on your complex samples, faster and easier than ever before.
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Boost the performance of your mass spectrometer and improve sensitivity, productivity, and data precision. iChemistry Solutions are the world's only reagents and consumables that are custom designed with your success in mind.
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From substantiating new discoveries through to end-to-end validated workflows for high-throughput biomarker testing in the clinic, thousands of scientists worldwide depend upon mass spec innovation from SCIEX to advance their work in the fields of clinical, research, omics and diagnostics.
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How do you protect your reputation and meet today’s global food safety standards? Whether you are a commercial lab or a food manufacturer, the quality of your food testing data is vital to your business. SCIEX solutions help you meet maximum residue limits (MRLs) with high-quality data that you can genuinely count upon. With a portfolio of applications, your lab can quickly and easily react to diverse market needs.
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How do you ensure the integrity of your results in an industry that is never constant? By accurately detecting even the smallest compound angles you can deliver evidence that stands. SCIEX forensic analysis solutions deliver fast, highly accurate data across a multitude of compounds and biomarkers, from the known to the new and novel.
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Transform the capacity and capability of your biologics pipeline with complete end-to-end solutions that make your lab more productive, and more successful. With a longstanding track record in pharma discovery, development and manufacturing, our unparalleled application knowledge with best-in-class hardware, software and support all integrate to revolutionize your lab.
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The SCIEX Now Learning Hub offers the most diverse and flexible learning options available, with best-inclass content that helps you to get the most out of your instrument and take your lab to the next level. Available personalized learning paths based on the latest memory science ensure better knowledge retention, and automated onboarding and enrollment means you’ll get up and running faster.
SCIEX Now Learning Hub offers the most diverse and flexible learning options available, with best-in-class content that helps you to get the most out of your instrument and take your lab to the next level. Available personalized learning paths based on the latest memory science ensure better knowledge retention, and automated onboarding and enrollment means you’ll get up and running faster.
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You can browse, filter, or search our extensive list of training offerings. Choose from over 100 self-paced eLearnings or search for an instructor-led course near you. Once you select the course you want to take, you will be directed to Learning Hub for enrollment (login required).
SCIEX Now Online is the Everything, Anytime destination for all your SCIEX support needs. You can keep track of activities that matter most to you and manage your lab in the most efficient way possible. Extensive self-help resources like our deep Knowledge Base, enable you to solve many problems on your own. SCIEX Now is available 24/7 and your new SCIEX instruments are automatically added to your profile when you purchase.
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LC-MS/MS assay development can be challenging, particularly for analytes that coelute with contaminants or become buried within background noise. The SCIEX SelexION differential mobility separation device (DMS) provides an extra level of selectivity so you can resolve difficult analytes and achieve higher confidence in detection and quantitation. Designed to install between the ionization source and the vacuum interface of your mass spectrometer, SelexION provides a further degree of separation beyond retention time and mass. SelexION uses gas phase differential ion mobility to enable the separation of coeluting compounds, isobaric and isomeric compounds, and compounds buried within high background noise. Instead of spending more time on LC separation strategies and sample preparation, SelexION simplifies your workflow with an innovative add-on separation solution. The SelexION differential mobility separation device:
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Require more information? Learn more
SelexION can enhance analyte detection, improve quantitation limits, simplify sample preparation, and shorten assay development time. With applications in food and environmental analysis, forensics, lipidomics, peptide and protein quantitation, and small molecule bioanalysis and metabolism, SelexION DMS can enrich your assays, streamline your workflows, and improve your overall productivity.
Easy to install
Compact and simple design allows the cell to be installed without the use of any tools and in less than 2 minutes
Robust and stable
Updated curtain plate to accommodate the differential ion mobility cell. Maintains the same level of robustness and stability associated with the original design
Watch Video
Combine sensitivity and selectivity with unmatched reproducibility and robustness
Video Length
For scientists who are challenged by assays with isobaric interferences and difficult-to-separate co-eluting contaminants, this fast, reproducible and easy-to-use approach will enhance the selectivity of your LC-MS/MS separations. Learn More >
Enhance selectivity without the need for additional complex sample preparation
Perform fast separation analyses compatible with UHPLC timescales
Overcome co-eluting matrix interferences and improve data quality in complex samples
Separate and quantify isobaric molecular species for more accurate biological insights
Maximize mass spec workflow flexibility with easy install that doesn’t require breaking the system vacuum
Used in pharmaceutical, academic and food and environment testing labs across the globe, SelexION DMS technology brings the power of differential ion mobility to even routine users. The technology is compatible with several SCIEX Triple Quad™, QTRAP and TripleTOF platforms. Explore the table below to see what SelexION device is right for your system.
We also offer the SelexION+ ion mobility cell, currently available for use on the SCIEX 6500+ series mass spectrometers. The SelexION+ device is enhanced by a jet injector that reduces the ion residence time within fringing fields at the DMS inlet. This delivers a 2-fold increase in transmission over the standard SelexION device.
Read more about SelexION technology >
From pharmaceutical drug discovery/development and lipidomic analysis to food, environmental testing and so much more, learn how SelexION technology has enhanced results in these key applications.
Improve lipid class separation for more confident lipid ID
Get a complete solution for lipidomics research
Improve selectivity for quantitative bioanalysis
Identify and quantify food contaminants
SelexION differential ion mobility technology takes some of the world's most advanced mass spectrometry systems and adds a new dimension of selectivity to enhance quantitative and qualitative performance. Compatible with many SCIEX systems, SelexION device can be installed and uninstalled within 2-minutes without breaking vacuum, giving you the freedom to use ion mobility technology as needed.
Most sensitive and selective system to push quantitation further than ever before
Sensitivity and performance to easily meet analytical and regulatory demands for low-level trace detection.
Achieve the optimum of quantitative performance
Highest sensitivity high-resolution mass system for comprehensive data acquisition
High-resolution mass system with ultra-fast acquisition speeds
SCIEX SelexION device is a small, planar mobility cell that significantly increases analytical separation power, even if compounds have identical molecular weights and chromatographic retention times, made possible by a mobility region and optional polar modifiers in the transport region.Watch the Video >
Two parallel flat plates define a mobility region, allowing nitrogen carrier gas to create forward directional flow between the ion source and the mass spec analyzer. Analytes are separated based on their respective size, shape, charge state and chemical interaction, prior to entering the mass spec.
Polar modifiers in the transport region can lead to a significant increase in analyte separation and peak capacity. Chemical modifiers, such as isopropanol or acetonitrile, influence ion mobility based on their ability to cluster with analytes.
See how the small, planar SelexION DMS device can enhance analytical separations for isobaric species and co-eluting contaminants.
SelexION offers a unique approach to separation that is unmatched by any other available method. Firstly, it is a planar device that separates ions based on differences in mobility in two different regions of the field dependent mobility curve (Ref 1). Secondly, due to its size, the system can operate with very short residence times with optimal performance when using chemical modifiers, and can be used in transparent mode to allow for maximal workflow flexibility.Learn More >
Other types of standard low field mobility devices, such as drift tubes, separate ions based upon differences in the low field mobility constant related to analyte mass, and are generally less effective at separating isobaric ions (Refs 2, 3).
Planar devices such as SelexION eliminates heterogeneous electric fields within the device, leading to increased resolving power compared to curved surface mobility devices (Refs 4, 5).
SelexION offers the ability to turn off separation voltage and operate in a ‘transparent’ mode to transmit all ions, providing the option to perform non-ion mobility assays without removing the front-end device (Ref 1).
