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Differential mobility spectrometry (DMS) and ion mobility spectrometry are analytical techniques used to separate hard to resolve ions based on their gas phase mobility. Multiple types of ion mobility devices exist, such as drift tubes, traveling wave, and high-field asymmetric waveform devices. However, none carry the power of SCIEX SelexION® technology that delivers highly-selective, robust and powerful ion separation that significantly enhances your quantitative and qualitative performance.
The SelexION® Differential Mobility Device can help you address your biggest analytical challenges:
|Rapid, sensitive analysis of sphingolipid variant profiles with simplified sample extraction||09/25/2020|
|Insights 120 Under the hood: SelexION® Differential Mobility Separation technology explained||06/08/2020|
|Analysis of Prostaglandin Isomers using the SelexION® Device||04/23/2020|
|Separation of Bile Acid Isomers with Differential Mobility Spectrometry||04/15/2020|
|Analysis of Chiral Amphetamines Using Differential Mobility Spectrometry and Mass Spectrometry||02/21/2020|
|A Clinical Research Method for the Measurement of LowLevel Testosterone in Serum using Differential Mobility Separation with LC-MS/MS||01/30/2020|
|Increased Throughput for the Characterization of Bispecific Antibodies on Subunit Level using SelexION® Differential Mobility Separation Technology||01/14/2020|
|SelexION from SCIEX: Ion Mobility Provides Solution to Selectivity Challenges in Steroid Analysis||12/18/2019|
|Differentiation of α2,3 and α2,6 Sialic Acid Linked Glycan Isomers||10/16/2019|
|SelexION Technology for TripleTOF Systems Site Planning Guide (DE)||08/01/2019|
|SelexION Technology for TripleTOF Systems Site Planning Guide||08/01/2019|
|SelexION Technology for TripleTOF Systems Site Planning Guide (FR)||08/01/2019|
|SelexION Technology for TripleTOF Systems Site Planning Guide (IT)||08/01/2019|
|SelexION Technology for TripleTOF Systems Site Planning Guide (ES)||08/01/2019|
|SelexION/SelexION+ Technology Site Planning Guide for SCIEX Triple Quad and QTRAP Systems (EN)||08/01/2019|
|SelexION/SelexION+ Technology Site Planning Guide for SCIEX Triple Quad and QTRAP Systems (DE)||08/01/2019|
|SelexION/SelexION+ Technology Site Planning Guide for SCIEX Triple Quad and QTRAP Systems (FR)||08/01/2019|
|SelexION/SelexION+ Technology Site Planning Guide for SCIEX Triple Quad and QTRAP Systems (IT)||08/01/2019|
|SelexION/SelexION+ Technology Site Planning Guide for SCIEX Triple Quad and QTRAP Systems (ES)||08/01/2019|
|SelexION/SelexION+ Technology Site Planning Guide for SCIEX Triple Quad and QTRAP Systems (ZH)||08/01/2019|
|SelexION Technology for TripleTOF Systems Site Planning Guide (ZH)||08/01/2019|
|SelexION Technology for TripleTOF Systems Site Planning Guide (JA)||08/01/2019|
|Triple Quad™ 5500 LC/MS/MS System and SelexIONTM technology||05/06/2019|
|Differential Ion Mobility-Enabling Accurate Analysis of Small and Large Molecules from Complex Biological Samples||03/25/2019|
|Separation of Ephedrine and Pseudoephedrine Isomers Using SCIEX SelexION Differential Mobility Technology||02/15/2019|
|SelexION/SelexION+ Technology User Guide for SCIEX Triple Quad and QTRAP Systems (IT)||01/15/2019|
|SelexION/SelexION+ Technology User Guide for SCIEX Triple Quad and QTRAP Systems (DE)||01/15/2019|
|SelexION/SelexION+ Technology User Guide for SCIEX Triple Quad and QTRAP Systems (FR)||01/15/2019|
|SelexION/SelexION+ Technology User Guide for SCIEX Triple Quad and QTRAP Systems (EN)||01/15/2019|
|SelexION/SelexION+ Technology User Guide for SCIEX Triple Quad and QTRAP Systems (ES)||01/15/2019|
|SelexION/SelexION+ Technology User Guide for SCIEX Triple Quad and QTRAP Systems (ZH)||01/15/2019|
|Separation of Bile Acid Isomers with Differential Mobility Spectrometry||12/03/2018|
|Resolution of Ether and Diacyl-Linked Phospholipids by Differential ION Mobility Spectrometry (DMS)||11/19/2018|
|Sensitive and Accurate Quantitation of Retinoic Acids in Biological Samples with QTRAP 6500 and SelexION Technology||11/12/2018|
|SelexION Technology: A New Solution to Selectivity Challenges in Quantitative Bioanalysis||11/06/2018|
|Differential Ion Mobility Separation of Iso-Elemental Lipid Species||11/02/2018|
|Separation of Diastereomeric Flubatine Metabolites using SelexION® Technology||10/16/2018|
|Differential Mobility Spectrometry Resolves Chlorine- and Acetate- Adducts of Phosphatidylcholine (PC)||10/09/2018|
|Differential Ion Mobility Separation of Glycosylceramides (Cerebrosides) SelexION Technology||09/01/2018|
|Exploring the Figures of Merit of Differential Mobility Spectrometry (DMS) Cells of Varied Geometries||06/06/2018|
|Using Differential Mobility Spectrometry and Machine Learning-Based Modelling to Predict the Physicochemical Properties of Molecules||06/05/2018|
|Differential Mobility Separation for Improving Lipidomic Analysis by Mass Spectrometry||03/05/2018|
|Differential Mobility Spectrometry Analysis of Glycans and Glycopeptides||01/31/2018|
|Differential Mobility Spectrometry Theory||12/20/2017|
|Selexion dms technology increasing the selectivity of lc msms analysis||12/06/2017|
|Omics Applications-SelexION® Differential Mobility Spectrometry Technology||10/11/2017|
|User Guide: SelexION and SelexION+ Technology Troubleshooting||09/30/2017|
|Bioanalysis Quantitation Applications eBook||09/25/2017|
|Determination of Limaprost in Human Plasma||09/13/2017|
|Selexion Valproic Acid Tech Note||08/31/2017|
|Solutions for Biotherapeutic Characterization||08/01/2017|
|SCIEX SelexION Series Ion Mobility System Declaration of Conformance||06/30/2017|
|Differential Mobility Separation with SCIEX SelexION Technology – A Novel Technique for the Bioanalysis of Poor Fragmenting Molecules Like Valproic Acid||06/29/2017|
|The Use of SelexION® to Increase Sensitivity for Trace Level Analysis of Small Polar Molecules||06/21/2017|
|Differential Mobility Spectrometry Resolves Isobaric Metabolite Overlap||06/15/2017|
|SCIEX Quantitation and Metabolism Solutions Brochure||05/26/2017|
|SelexION Differential Ion Mobility Technology||05/01/2017|
|SelexION Differential Ion Mobility Intro||04/10/2017|
|SelexION Differential Mobility Technology Address your Biggest Analytical Challenges||04/01/2017|
|Advanced Biotransform Solution Guide||03/28/2017|
|Dysregulated Lipid Profiles of Non-Alcoholic Fatty Liver Disease (NAFLD)||12/05/2016|
|Differential Mobility Separation Mass Spectrometry for Quantitation of Large Peptides in Biological Matrices||12/01/2016|
|SelexION ION Mobility Technology - A New Dimension in Selectivity||11/28/2016|
|LC-MS/MS Quantitation of Underivatized Glyphosate and Other Polar Pesticides||06/01/2016|
|Novel Chemical Standards Kits Enable Facile Lipid Quantitation||05/01/2016|
|Quantification of Peptides with Poor MS/MS Fragmentation using Novel Jet Injector SelexION® + MIM Workflow||01/31/2016|
|Automating Optimization of Compensation Voltages for Differential Mobility Separation using Skyline||12/11/2015|
|Multiple Mass Spectrometric Strategies for High-Selectivity Quantification of Proteins and Peptides||12/02/2015|
|Rapid Quantitation of Substance P in Plasma using Differential Mobility Spectrometry and Micro Flow Liquid Chromatography||12/01/2015|
|Using Differential Mobility Spectrometry to Separate and Localize Sites of Post-Translational Modifications on Peptides||11/01/2015|
|Quantitative Lipid Analysis using MRM and Differential Ion Mobility Spectrometry (DMS)||09/01/2015|
|Resolution of Sphingomyelins in Complex Lipid Extracts by Differential Ion Mobility Spectrometry (DMS)||09/01/2015|
|User Guide: SelexION Technology for TripleTOF Systems User Guide||05/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems User Guide (DE)||05/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems User Guide (IT)||05/31/2015|
|User Guide: SelexION Technology for TripleTOF Systems User Guide (FR)||05/31/2015|
|SelexION Technology for TripleTOF Systems User Guide (ES)||05/31/2015|
|Caring for TurboV Ion Source Electrodes||01/01/2014|
|SelexION Technology User Guide||05/10/2013|
For scientists who are challenged by assays with isobaric interferences and difficult-to-separate co-eluting contaminants, this fast, reproducible and easy-to-use approach will enhance the selectivity of your LC-MS/MS separations.
Enhance selectivity without the need for additional complex sample preparation
Perform fast separation analyses compatible with UHPLC timescales
Overcome co-eluting matrix interferences and improve data quality in complex samples
Separate and quantify isobaric molecular species for more accurate biological insights
Maximize mass spec workflow flexibility with easy install that doesn’t require breaking the system vacuum
SCIEX SelexION device is a small, planar mobility cell that significantly increases analytical separation power, even if compounds have identical molecular weights and chromatographic retention times, made possible by a mobility region and optional polar modifiers in the transport region.
Two parallel flat plates define a mobility region, allowing nitrogen carrier gas to create forward directional flow between the ion source and the mass spec analyzer. Analytes are separated based on their respective size, shape, charge state and chemical interaction, prior to entering the mass spec.
Polar modifiers in the transport region can lead to a significant increase in analyte separation and peak capacity. Chemical modifiers, such as isopropanol or acetonitrile, influence ion mobility based on their ability to cluster with analytes.
See how the small, planar SelexION DMS device can enhance analytical separations for isobaric species and co-eluting contaminants.
SelexION offers a unique approach to separation that is unmatched by any other available method. Firstly, it is a planar device that separates ions based on differences in mobility in two different regions of the field dependent mobility curve (Ref 1). Secondly, due to its size, the system can operate with very short residence times with optimal performance when using chemical modifiers, and can be used in transparent mode to allow for maximal workflow flexibility.
SelexION offers the ability to turn off separation voltage and operate in a ‘transparent’ mode to transmit all ions, providing the option to perform non-ion mobility assays without removing the front-end device (Ref 1).
Used in pharmaceutical, academic and food and environment testing labs across the globe, SelexION DMS technology brings the power of ion mobility to even routine users. The technology is compatible with several SCIEX Triple Quad™, QTRAP® and TripleTOF® platforms. Explore the table below to see what SelexION device is right for your system.
SelexION+ ion mobility cell is also available for use on SCIEX 6500+ Series mass spectrometers. The SelexION+ device is enhanced by a jet injector that reduces the ion residence time within fringing fields at the DMS inlet. This delivers a 2-fold increase in transmission over the standard SelexION device.
From pharmaceutical drug discovery/development and lipidomic analysis to food, environmental testing and so much more, learn how SelexION technology has enhanced results in these key applications.
SelexION Differential Ion Mobility Technology takes some of the world's most advanced mass spectrometry systems and adds a new dimension of selectivity to enhance quantitative and qualitative performance. Compatible with many SCIEX systems, SelexION device can be installed and uninstalled within 2-minutes without breaking vacuum, giving you the freedom to use ion mobility technology as needed.
Most sensitive and selective system to push quantitation further than ever before
Sensitivity and performance to easily meet analytical and regulatory demands for low-level trace detection.
Highest sensitivity high-resolution mass system for comprehensive data acquisition
Top-5 Reasons to Use SelexION Technology
SelexION Applications eBook
SelexION Technology Peer-Reviewed Publications
Pharma SelectION Peer-Reviewed Publications
Video- Introduction to SelexION DMS Technology
Video- SelexION Technology in Action
User Guide- SelexION and SelexION+ Systems User Guide
SelexION Ion Mobility Brochure
User Guide- SelexION and SelexION+ Technology Troubleshooting
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