Contact us today and try SCIEX OS software for free, request a demo or ask for more information.
SCIEX OS software 2.2 is mass spectrometer software for the modern laboratory. Its remarkable quantitative usability, efficiency and integrity will transform and streamline your LC-MS/MS workflows. The powerful algorithms and automation at its core will enable you to make informed decisions quickly.
Specialist in Protein Mass Spectrometry
Peak Proteins, UK
SCIEX OS is a quick to learn software that will increase your productivity and consistently deliver high-quality and actionable data from your mass spectrometry workflows.
Whether you operate a single SCIEX instrument with SCIEX OS or a fleet of them you benefit from an integrated experience across them all from QTOF, triple quadrupole and QTRAP.
The accuracy, precision and consistency of SCIEX OS ensures your data quality is never compromised–through every stage of your mass spectrometry workflow–batch after batch.
Quantification and qualification processing
Acquisition, control and quantification and qualification processingFEATURES
Optimized quantification processing
* Add-on module, separate license required
** Excluding the SCIEX Triple Quad 4500, 5500+ and 6500+ systems
"Moving forward, labs will need to consider the complexity of the science that they are using for their toxicology screening. Streamlined workflows and efficient software play an extremely important role in achieving that."
Program Manager, NPS Discovery / CFSRE Philadelphia, Pennsylvania, US
"It's a huge leap forward in innovation, just to make mass spec simpler and more accessible to people. SCIEX OS has enabled anyone to walk up to the system and run their intact mass samples."
Specialist in Protein Mass Spectrometry Peak Proteins, UK
"In new innovations, the software is key, as the software enables the creation of results. Software that integrates data acquisition, processing, interrogation and reporting gives added value in terms of efficiency with which these results can be generated."
Senior Principal Scientist for Assay Development and Analytical Support Development Bioanalysis group Janssen R&D, Belgium
|Software Plus||Software Legacy||Software Advance||Software Assist|
|Software upgrades (e.g., version 1.6.3 to 1.7) for eligible software|
|Software updates (includes point releases and hotfixes)|
|Access to premium Learning Hub and knowledge base content online|
|Priority access to remote software support (during business hours) via telephone and SCIEX Now|
|Discounted rates on selected software licenses and related software services|
|Discounted rates for validation and compliance services for easier upgrades|
Existing users of SCIEX OS software can download the latest updates here.
Follow this link to activate a new SCIEX OS software licence.
The latest operating manuals are available here for your reference.
Here is a link to all the relevant end-user license agreements for your version of SCIEX OS software.
Please visit our training section for courses on how to further your SCIEX OS software experience.
Spend less time digging for answers. Only review data of interest with flag-based labelling and filtering tools.
Increase performance with the powerful AutoPeak integration algorithm for more reliable integration across samples, batches and analytes. This will allow you to achieve reliable peak integration with ease, even with low-level peaks and complex matrices. No manual intervention is needed to re-integrate peaks, remove interferences or adjust retention time.
In a high-throughput lab environment that requires consistency and the continued delivery of high-quality data, you need a layout for your analysis that is familiar and enables you to interpret data faster. Custom workspaces can now be saved.
Simplify calibration curve review.
SCIEX OS software has the ability to support “IF” statements for your analysis queries. There is functionality to execute calculations within the “IF” statement. “IF” statements can be built into the flagging rules when the outcome is a numeric value. Some of the data analysis you wish to conduct may be complex, therefore there is no limitation on the formula size of your query. Nested “IF” statements are also supported, and they can be packaged into a .frml file format and shared.
Import processing methods into SCIEX OS. Your Analyst® Software or MultiQuant™ Software processing methods can be imported directly into SCIEX OS Software.
This is where you enter details about your samples, including the mass spectrometry and liquid chromatography methods and the autosampler values, such as rack position, plate type, vial position and sample injection volume. You can also indicate the processing method to use and where to save the results file in the directory. Building a batch is simple and straightforward, and any existing Analyst® Software methods can be directly imported into SCIEX OS Software.
Other features available in the Batch workspace include auto-calibrate functionality, which enables accurate mass systems to select the right type of calibration solution for your method and the plate layout of the autosampler rack. Previously saved batches can also be reopened, and the Manage tab can be used for adding rows to your batch. When your details are entered, the batch is ready to go and you can hit Submit.
Acquire data overnight, and have it waiting for you in the morning. By incorporating your processing method into your batch, once a sample is finished acquiring, it will start processing automatically. When you return to work, the data is ready for your review, saving time and getting to the results faster.
After you hit Submit in the Batch workspace, you can view the progress of your analysis in the Queue workspace. The acquisition status is displayed, so you can quickly see that your samples are running smoothly. The estimated start time allows you to forecast when the analysis will be complete. The Queue workspace displays many of the same details from the Batch workspace, such as MS and LC methods. You have the power to start and stop the queue from here, should you wish to make changes to your batch.
Decision rules functionality allows for immediate detection of failures and implementation of corrective action based on criteria that you establish. This non-subjective decision making adapts to changing conditions during analysis. The decision rules functionality continually checks against customized criteria. With decision rules, you don’t have to wait for acquisition, data processing and data review to discover failures and take action.
Create your own rules to address failures when they occur. With decision rules, you are able to associate your processing method in the batch and apply flagging rules to make real-time decisions during data acquisition, which saves time and reduces sample loss.
In the MS Method workspace, you can create a standard MRM or MRMHR method, depending on whether you are operating a SCIEX Triple Quad™ system or an accurate mass instrument. If you are running a SCIEX accurate mass instrument, you might want to create a SWATH acquisition method. Guided method creators are available to assist you in developing new methods for new analytes you want to analyze.
Source parameters (such as source gases, curtain gas and temperature settings) for the Turbo V ion source and the OptiFlow Pro ion source can be configured here.
The Experiment section is for selecting the type of experiment to run, such as TOF MS, MRM and MRMHR. You can select multiple experiments for your analysis, so your system can acquire even more data for you.
Whether it's an infusion, flow injection, on-column or MRM3 approach, the automated compound optimization feature for quantification is simple, flexible and completely automated. There are also options for choosing optimal parameters such as signal-to-noise (S/N) ratio or intensity requirements.
Scheduled MRM (sMRM) is an exciting feature that helps drive the accuracy and precision of your mass spectrometer. sMRM accounts for any potential retention time (RT) drifts, and all RTs can be updated with a single click. sMRM also has functionality to call out single dwell time instances so you can maximize the abundance of low-intensity ions. In addition, interactive sMRM plots dynamically update with any changes in the sMRM method.
Easily transfer acquisition methods from Analyst® Software to SCIEX OS. This saves time and helps prevent transcription errors. Convert your acquisition method directly in the SCIEX OS MS Method workspace and your method transfer is done!
SCIEX OS Software enables you to build separate liquid chromatography methods. The information displayed in the LC Method workspace will depend on the LC configuration you select for your analysis. Here, you can input all the details regarding flow rates, autosampler conditions, column oven temperature controls and potential wavelength data for photodiode array detector (PDA) wavelengths. You can also adjust any other settings you may need, such as executing an auto-purge before analysis.
You can open and edit previously saved methods and even disable modifications until a designated administrator unlocks the capability.
Use one LC method for multiple MS methods to reduce method development time, explore different MS methods and simplifying method management.
The Tuning Procedures drop-down menu shows specific options for you instrument. You can use the detector optimization tool to optimize the detector voltage if you notice the sensitivity of the system seems low.
SCIEX OS Software enables automated tuning for the SCIEX Triple Quad™ 7500 LC-MS/MS System – QTRAP® Ready and the X500 series QTOF systems by calibrating all scans across all modes for added confidence that your system is ready to use with fast, easy and simple tuning. Your instrument will be calibrated correctly with built-in acceptance criteria for a higher first-time success rate, saving you a significant amount of time.
A single calibrant for both positive and negative mode means:
Follow detailed step-by-step instructions to easily tune and calibrate your instrument. Standard tuning as well as custom tuning procedure options are available. Built-in specifications for mass calibration, peak width, and intensity ensures confidence that your instrument is in good health.
The navigation tools in the Explorer workspace allow you to quickly move through the samples for an overview of your data. You can view the data in several ways depending on your preference.
Save time when you need to dig deeper into the raw data, with a click of the mouse. PeakView® Software is wrapped inside SCIEX OS Software in the Explorer workspace. Easily launch the Explore workspace from the peak review pane in Analytics in one click!
The Configuration workspace displays active devices, allowing you to activate or deactivate the hardware in your workflow.
The Configuration workspace also provides the ability to add devices you may need or edit the configuration of your instruments. Within the workspace, you can adjust settings for queue management, such as maximum idle time allowed before the system goes into standby and the maximum number of samples allowed. There are also rule settings that advise users on what to do when a sample is missing, for example. If you are operating one of the X500 series QTOF instruments, you can specify calibration settings and what the system should do if there is a calibration failure.
Easily set up and manage multiple devices on one mass spectrometer. You can add devices individually and simply check the box next to the device you want to activate.
The Library workspace is used to import a library that you would like to use as part of your workflow. Libraries provide additional confirmation and assurances for confirm your data acquisitions. You can import a LibraryView™ software package or your own custom library. During this process, you can select which compounds you would like to include in your processing. You may want to include every compound in the SCIEX All-in-One HR-MS/MS Library, for instance, or just extract the compounds that are crucial to your experiment.
Easily add new compounds to MS/MS libraries directly from the peak review pane, making library building a breeze!
The Event Log workspace shows you useful diagnostic information and events happening within SCIEX OS Software. Within this workspace, you can archive a log at your specific intervals. You can also open previously archived event logs here, so you can dig into any of the information that may be of use.
All events, all in one place. You can see and export all events, or you can select devices or workspaces to see specific events.
From compliant routine analyses to flexible research workflows, the intuitive Audit Trail workspace ensures full traceability and accountability. It includes built-in data integrity features that allow you to tailor each functionality specifically to your lab’s compliance and data security requirements.
SCIEX integrated compliance services include integrated analytical instrument qualification and software validation packages that cover your complete SCIEX system workflow
All events, all in one place. You can see and export all events, or you can select devices or workspaces to see specific events.