SCIEX Triple Quad™ 4500 LC-MS/MS System

Consistent, Reliable Quantitation Around the Clock

When your lab is faced with lots of samples and impending deadlines, you can't afford an unreliable mass spec system that could put your lab or your reputation at risk. Some mass spec solutions can crack when faced with pressure:

  • Data quality erodes during long runs
  • Data processing is time consuming and becomes a bottleneck
  • Getting immediate answers to solve problems as they arise is impossible

These challenges can be detrimental to your lab's productivity. The 4500 system is designed to conquer them.

Triple Quad 4500 System
Key Features

Mass Range

5 – 2000 Da

Flexible Ionization Options

Options include Electrospray (ESI) ionization and heated nebulizer ionization probes.

Polarity Switching

50 msec in MRM and Scheduled MRM modes

Detector Type

AcQuRate Pulse Counting CEM

Cutting Edge and Reliable Technology

Technology You Can Rely On

Maximize uptime with a system that can handle even the most difficult matrices with ease. Includes legendary Turbo V™ technology, patented QJet® Ion Guide design, and the ultimate Pulse Counting detector.

Turbo V Source

This legendary source provides high-sensitivity analysis over a wide range of flow rates with quick-change APCI and TurboIonSpray® probes.

QJet Ion Guide

The patented design yields excellent ion containment and operates at high pressure, providing better collisional focusing to enhance ion transmission for ultimate sensitivity.

AcQuRate™ Pulse Counting Detector

The detector technology works in combination with a pulse overlap correction algorithm, enabling more accurate and precise ion detection over a wide dynamic range.

End-to-end Performance and Support

Discover the line-up from LC to support that complements the 4500 system so your lab can realize your full productivity potential.

We know that the mass spec system is just one component to the full workflow, and that maximum productivity is only achieved when all the parts are functioning at their peak – from the LC injection to delivering reliable reports of results. Here’s how the 4500 works together with the supporting cast that bring you from system to success.

HPLC

The chromatographic reliability you need to complement your mass spec.

Software

Discover the software that will speed-up your MRM quantitation data processing.

Support

From training to services and system monitoring, the SCIEX Success Network is your partner for maximum productivity.

Productivity Across Applications

See the 4500 system in action for these common workflows.

The 4500 system is a great fit for applications requiring round-the-clock quantitation, with the robustness to handle repeated injections of complex samples and reliability to minimize downtime. Here you can explore methods and see how the 4500 system performs in these selected applications.

Food allergen testing

93 forensic drugs in urine

Amino acid quantitation

Gluten quantitation in foods

Key Features

Mass Range

5 – 2000 Da

Detector Type

AcQuRate Pulse Counting Detector

Scan Types

Q1 MS, Q3 MS, Product Ion, Precursor Ion, Neutral Loss or Gain, MRM

Ionization Sources

Turbo V; TurboIonSpray; Atmospheric-pressure chemical ionization (APCI); DuoSpray®

Resources

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4500 Series of Instruments Site Planning Guide (ZH)

4500 Series of Instruments Site Planning Guide (IT)

4500 Series of Instruments Site Planning Guide (ES)

4500 Series of Instruments Site Planning Guide (FR)

4500 Series of Instruments Site Planning Guide (JA)

Quantification of Dopamine, Epinephrine, Norepinephrine in Human Plasma by SCIEX Liquid Chromatography-Tandem Mass Spectrometry

SCIEX LC-MS-MS Application Technology on Origin Identification of Dairy Products based on Alpha-lactalbumin and Beta-lactoglobulin

Determination of Six Antiepileptic Drugs in Serum by SCIEX Triple Quad System (ZH)

The application solution for determination of Desloratadine and other 14 kinds of components in Cosmetics by LC-MS/MS method

Determination of Aflatoxins B and G in Grain

A Rapid Screening and Quantitative LC-MS-MS Method of 189 Veterinary Drug Residues in Animal Food by Triple QuadTM 3500

LC-MS-MS Method for Determination of 523 Pesticide Residues in Traditional Chinese Medicine

The Solution of Analysis 13 Nitrosamines in Drinking Water by LC-MS-MS

Determination of Six Antipsychotic Drugs in Serum by SCIEX Liquid Chromatography-Tandem Mass Spectrometry

Determination of Chloramphenicol Thiamphenicol and Florfenicol Residues in Fish

Determination of Tetracycline Antibiotic Residues in Animal-derived Food

Quantification of 74 Prohibited Hormones in Cosmetics Using LC-MS-MS System

Determination of Liposoluble Vitamins in Micro Blood Samples by SCIEX Liquid Chromatography Tandem Mass Spectrometry

Determination of Sulfonamide Residues in Chicken

Determination of Malachite Green and Crystal Violet Residues in Fish

The Application Solution for Determination of Minoxidil and Other 6 Kinds of Components in Cosmetics by LC-MS-MS Method

Determination of Linezolid and Fluconazole in Plasma by SCIEX Liquid Chromatography-Tandem Mass Spectrometry (ZH)

Determination of 74 Pesticides and metabolites in Soil By LC-MS-MS

Determination 29 β-Agonists in Animal Derived Food by LC-MSMS Method (ZH)

Determination of Beta-agonist Residues in Meat

Rapid Screening and Quantification of 223 Illegal Drug Residue in Feed Using LC-MS/MS (ZH)

Rapid Screening of Phenyl-sulfonate Ester Genotoxic Impurities by pMRM-IDA-EPI

Determination of 23 Phthalate Esters in Drinking Water By LC-MS-MS

Determination of Quinolone Residues in Animal-derived Food

Determination of Animal Species Origin from Blood Products by LC-MS-MS

Determination of Genotoxic Impurities Methyl Methanesulfonate and Ethyl Methanesulfonate on SCIEX Triple QuadTM 4500 system

Determination of 23 Phthalate Esters in Cosmetics By LC-MS-MS

Determination of roxarsone in animal feeds using solid-phase extraction coupled with high performance liquid chromatography-tandem mass spectrometry

Determination of Malachite Green and Crystal Violet Residues in Fish

The Application of Multiple Heart-Cutting 2D-LC- X500B in the Analysis of Drug Impurities in Proinsulin (ZH)

Determination of trace angiotensin II in plasma with SCIEX Triple Quad 4500 LC-MS/MS system (ZH)

Determination of 13 Bile Acids in Serum by SCIEX Liquid Chromatography-Tandem Mass Spectrometry

Determination of 8 Polar Pesticides and metabolites in Plasma and Urine Without Derivatization (ZH)

Simultaneous Determination of Aldosterone and Angiotensin I from Human Plasma Using LC-MS/MS (ZH)

The Application of Analysis 13 Haloamides in Drinking Water by LC-MS-MS

Non-derivation LC-MS-MS method for the analysis of nine biogenic amines in food

Determination of Genotoxic Impurities N-nitroso-N-methyl-4-aminobutyric acid on SCIEX Triple QuadTM 4500 system

Rapid Determination of 8 Macrolides Antibiotics in Cosmetics

Determination of Aflatoxins B&G in Grain

LC-MS-MS Method for Rapid Determination of 30 Forbidden Pesticides In Traditional Chinese Medicine

The Application Solution for Determination of Fluconazole and other 8 Kinds of Components in Cosmetics by LC-MS-MS Method

Determination of Tetracycline Antibiotic Residues in Animal-derived Food

Quantitation of 8 Fat Soluble Vitamins in Formula Infant Milk

Analysis of Six Organotin Compounds in Food package Material by LC-MS-MS

Determination of NMDA in Ranitidine Hydrochloride by LC-MS-MS

A Rapid Screening and Quantification Method of Forbidden and Restricted Pesticides in Traditional Chinese Medicine by LC-MS-MS

Simultaneous Determination of 14 Paralytic Shellfish Toxins in Seafood using LC-MS-MS

Determination of Nitrofuran Metabolites in Animal-derived Food

SCIEX Triple Quad 4500 System Quickly Identify the Authenticity of Colloid Drugs

Detection of 8 Antioxidant Residues in Food Package by Triple Quad 4500

Analysis 106 Compounds in Cell Supernatant by Using LC-MS-MS

Determination of Phenoxy Carboxylic Acids Herbicide in Water by LC-MS-MS

Determination of Caspofungin Posaconazole Voriconazole N-Oxide and Voriconazole in Plasma by SCIEX Liquid Chromatography-Tandem Mass Spectrometry

Rapid Determination of The Genotoxic Impurities N-Nitrosodiethylamine by LC-MS-MS

A Rapid Quantitative Method of LC-MS /MS for Dichlorvos in Sea Cucumbers (ZH)

The power of SCIEX Triple Quad liquid chromatography tandem mass spectrometry to detect polycystic ovarian syndrome related androgen (ZH)

Determination of Chloramphenicol Thiamphenicol and Florfenicol Residues in Fish

Determination of seven Antineoplastic and antibacterial drugs in Serum by SCIEX LC-MS/MS

Simultaneous Determination of 7 Kinds of Local Anesthetics in Cosmetics by High Performance Liquid Chromatography-Mass Spectrometry (ZH)

SCIEX LC-MS-MS Application Technology on Quantitation of Lactoferrin in Dairy Products

The Solution of Methamphetamine Detection

Detection of 24 Perfluoroalkyl Substances in Surface water by Triple Quad TM 4500

Simultaneous determination of five cytarabine metabolites and analogs with SelexION Ion mobility Mass Spectrum (ZH)

Detection of Methylmalonic Aciduria by Ion Chromatography Tandem Mass Spectrometry (ZH)

Determination of Quinolone Residues in Animal-derived Food

Fast and Simultaneous Analysis of Ethanol Metabolites and Barbiturates in Human Urine

Fast Screening Method for 86 Forensic Analytes in Human Urine

Analysis of PFAS in drinking water with EPA Method 537.1 and the SCIEX QTRAP® 4500 System

Efficiently Designed Workflows Provide Accurate Results in Forensic Analysis of THC-COOH in Hair

Quantitation of Aflatoxin M1 in Milk using SCIEX QTRAP® 4500 LC-MS/MS System

Cannabis for Per Se Law Testing in Whole Blood using theSCIEX Triple Quad QTRAP 4500 LC-MS/MS System

Nitrosamine Disinfection Byproducts in Drinking Water, LC-MS

Rapid Analysis of Genotoxic Nitrosamines

Identification and Quantification of Designer Drugs in Urine by LC-MS/MS

Microsoft Word - Loratadine tech note 29Sep2017.docx

CYP4500 Protein Assay - Human Induction Kit Extended Panel

Quantification of Major Metabolites of K2 in Human Urine

Screening for Legacy and Novel PFASs Using SCIEX Fluoros Library

Microsoft Word - FINAL CF1836_RUO-MKT-02-2173-A_Automation Ethanol Metabolites in Urine.docx

Rapid Detection of SDHIs in tea by SCIEX Triple Quad LC-MS/MS system

Determination of Nitrofuran Metabolites in Animal-derived Food

SCIEX vision Journal Issue 4

Compruebe y maximice la calidad de sus productos agriculturales

Determination of Beta-agonist Residues in Meat

List of Published Articles of Therapeutic Drug Monitorings (TDM) with SCIEX LC-MS/MS System (Volume 2)

List of Published Articles on Quantitative Methods of Clinical Diagnostics/Lab-Developed Tests (LDTs) with SCIEX LC-MS/MS System

Drug Impurity Analysis Solution

Catalogue of Literatures on target lipidomics using Triple Quad QTRAP mass spectrometry (Volume 1)

Catalogue of Literatures on Metabolomics using SCIEX mass spectrometry (Volume 1)

List of Published Articles of Therapeutic Drug Monitorings (TDM) with SCIEX LC-MS/MS System (Volume 3)

List of Published Articles with SCIEX LC-MS-MS System-Clinical-Volume 4

Determination of Sulfonamide Residues in Chicken

Folder for The Flyers of Food Safety Monitoring Holistic Solution

List of Published Articles with SCIEX LC-MS-MS System-Clinical-Volume 3

List of Published Articles with SCIEX LC-MS-MS System-Clinical-Volume 2

List of Published Articles of Therapeutic Drug Monitorings (TDM) with SCIEX LC-MS/MS System (Volume 4)

Catalogue of Literatures on untarget lipidomics using SCIEX high resolution mass spectrometry (Volume 1)

Catalogue of Literatures on Traditional Chinese Medicine (Volume 1)

List of Published Articles of Therapeutic Drug Monitorings (TDM) with SCIEX LC-MS/MS System (Volume 1)

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Rapid Determination of Nitrosamines of Genotoxic Impurities in Metformin by Triple QuadTM 4500 System

Challenges of screening and identifying NPS in the forensic laboratory

Application of SCIEX 3500 triple quadrupole liquid chromatography mass spectrometry platform for the detection of 30 prohibited pesticides and their metabolites in Chinese herbal medicines and decoction pieces

Novel Psychoactive Substances - Infographic

Detecting and identifying NPS: a brief history

The growing problem of NPS

Overcoming NPS screening challenges in the forensic laboratory

Detecting novel psychoactive substances - the workflow

SCIEX中国药典新规定的完整解决方案

基于SCIEX三重四极杆质谱系统对食品接触材料中丙烯酰胺迁移量的测定

Instrumentenreihe 4500 Handbuch zur Standortplanung

Customer case study Dr.Nimmi Kansal

Rapid and Sensitive Analysis of a 93-Compound Forensic Panel in Urine

LC-MS/MS Method for Rapid Determination of 30 Forbidden Pesticides In Traditional Chinese Medicine

Approaches to drug screening using Triple Quadrupole, QTRAP and QTOF technologies

Harnessing the power of mass spectrometry for early novel psychoactive substances (NPS) detection

LC-MS/MS 技术平台

Food-Fraud-Authenticity

Fast and simultaneous analysis of ethanol metabolites and barbiturates using the QTRAP® 4500 LC-MS/MS system

Rapid and Sensitive Analysis of a 93-Compound Forensic Panel in Urine using the QTRAP/Triple Quad 4500 LC-MS/MS System

Forensic Compendium

Techniques and solutions for forensic drug screening: an interview with Timothy Fassette

SCIEX Triple Quad™ 4500 LC-MS/MS System on Simultaneously Detection of Trimethylamine and Trimethylamine Oxide in human serum

The age of novel psychoactive substances

Applications of SCIEX LC-MS/MS System for Chinese Pharmacopedia (ZH)

Determination of Five Antibiotics and their Metabolites in Serum by SCIEX LC-MS/MS

SCIEX Tandem Mass Spectrometry Method for Quantification of Chondroitin Sulfate and Dermatan Sulfate by Methanolysis Derivatization

Determination of 4 nitrophenol compounds on SCIEX Triple QuadTM 4500 system

The Determination of Aflatoxins in Traditional Chinese Medicines using LC-MS/MS

The Determination of Zearalenone in Traditional Chinese Medicines using LC-MS/MS

LC-MS/MS法快速测定动物源食品中205种兽药的完整解决方案

应用LC-MS/MS快速分析化妆品中10种α-羟基酸

Software

Chemical Standards

Part Number Kit Name/Instrument Description
4406127 MS Chemical Kit 1, Low-High Conc. PPGs Standards chemical kit with low/high concentrations of polypropylene glycol polymers (PPGs). This kit includes all solutions necessary for installation and calibration for all SCIEX Triple Quads, excluding the API 2000™ and API 3000™ instruments.
4412399 MS Chemical Kit2, Higher Conc. PPGs Standards chemical kit with High Concentrations PPGs. This kit includes all solutions necessary for installation and calibration for all API 2000 and 3000 instruments.
4465788 SelexION® Calibration Solution Installation and Calibration Solution for SelexION Ion Mobility Source.
5056819 Essential LCMS Performance Kit Environmental Certified QC kits for use on SCIEX Triple Quad and QTRAP® 4500, 5500, 6500 and 6500+ systems, coupled with high flow LC systems, to test performance in both positive and negative modes for Environmental applications.
5056822 Essential LCMS Performance Kit Toxicology Certified QC kits for use on SCIEX Triple Quad and QTRAP 4500, 5500, 6500 and 6500+ systems, coupled with high flow LC systems, to test performance in both positive and negative modes for Toxicology applications.
5056816 Essential LCMS Performance Kit Small Molecule Pharma Certified QC kits for use on SCIEX Triple Quad and QTRAP 4500, 5500, 6500 and 6500+ systems, coupled with high flow LC systems, to test performance in both positive and negative modes for Pharma (Small Molecule) applications.
5056815 Essential LCMS Performance Kit - Peptide Certified QC kits for use on SCIEX Triple Quad and QTRAP 4500, 5500, 6500 and 6500+ systems, coupled with high flow LC systems, to test performance in positive mode for Peptide applications.