Consistent, Reliable Quantitation Around the Clock

SCIEX Triple Quad™ 4500 LC-MS/MS System

When your lab is faced with lots of samples and impending deadlines, you can't afford an unreliable mass spec system that could put your lab or your reputation at risk. Some mass spec solutions can crack when faced with pressure:

Data quality erodes during long runs
Data processing is time consuming and becomes a bottleneck
Getting immediate answers to solve problems as they arise is impossible

These challenges can be detrimental to your lab's productivity. The 4500 system is designed to conquer them.

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Key features

Mass range

5 – 2000 Da

Flexible Ionization Options

Options include Electrospray (ESI) ionization and heated nebulizer ionization probes.

Polarity Switching

50 msec in MRM and Scheduled MRM modes

Detector Type

AcQuRate Pulse Counting CEM

Cutting Edge and Reliable Technology

Technology You Can Rely On

Maximize uptime with a system that can handle even the most difficult matrices with ease. Includes legendary Turbo V™ ion source, QJet® ion guide design, and the ultimate Pulse Counting detector.

Turbo V Source

This legendary source provides high-sensitivity analysis over a wide range of flow rates with quick-change APCI and TurboIonSpray® probes.

QJet Ion Guide

The innovative design yields excellent ion containment and operates at high pressure, providing better collisional focusing to enhance ion transmission for ultimate sensitivity.

AcQuRate™ Pulse Counting Detector

The detector technology works in combination with a pulse overlap correction algorithm, enabling more accurate and precise ion detection over a wide dynamic range.

Discover the line-up from LC to support that complements the 4500 system so your lab can realize your full productivity potential.

We know that the mass spec system is just one component to the full workflow, and that maximum productivity is only achieved when all the parts are functioning at their peak – from the LC injection to delivering reliable reports of results. Here’s how the 4500 works together with the supporting cast that bring you from system to success.

HPLC

The chromatographic reliability you need to complement your mass spec.

Software

Discover the software that will speed-up your MRM quantitation data processing.

Support

From training to services and system monitoring, the SCIEX Success Network is your partner for maximum productivity.

See the 4500 system in action for these common workflows.

The 4500 system is a great fit for applications requiring round-the-clock quantitation, with the robustness to handle repeated injections of complex samples and reliability to minimize downtime. Here you can explore methods and see how the 4500 system performs in these selected applications.

Key features

Mass range

5-2000 Da

Detector Type

AcQuRate Pulse Counting Detector

Scan Types

Q1 MS, Q3 MS, Product Ion, Precursor Ion, Neutral Loss or Gain, MRM

Ionization Sources

Turbo V; TurboIonSpray; Atmospheric-pressure chemical ionization (APCI); DuoSpray®

List of Published Articles on Quantitative Methods of Clinical Diagnostics/Lab-Developed Tests (LDTs) with SCIEX LC-MS/MS System

Quantification of Dopamine, Epinephrine, Norepinephrine in Human Plasma by SCIEX Liquid Chromatography-Tandem Mass Spectrometry

SCIEX LC-MS-MS Application Technology on Origin Identification of Dairy Products based on Alpha-lactalbumin and Beta-lactoglobulin