BioPhase 8800 system


The BioPhase 8800 system is a multi-capillary electrophoresis system that enables biopharma scientists to run multiple samples in parallel, accelerating the development and execution of sensitive, high-throughput analytical methods. The increased throughput and reproducibility of the system minimizes bottlenecks in the drug development pipeline, helping shorten time to market.

Check out the newly added capability for fast glycan analysis on the BioPhase 8800 system by navigating below:

BioPhase 8800 System

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Multiply your results. Multiply your success. Accelerate the development of your biotherapeutics.

Innovated from the ground up, the BioPhase 8800 system helps biopharmaceutical labs take charge of their development pipelines.

Scientists can now assess molecular liabilities more quickly, allowing rapid developability assessments to streamline the selection of candidates to be progressed into an effective therapy.

Run more samples, and more molecules, on a single system through not 1, but 8 capillaries in parallel.

Existing approaches to detect and characterize changes during development of monoclonal antibodies (mAbs), next-generation therapeutics and gene therapies are challenged to deliver the detailed information you need in the time you need it.

The BioPhase 8800 system facilitates parallel processing of 8 samples simultaneously, while retaining the capability to deliver sensitive capillary electrophoresis sodium dodecyl sulfate (CE-SDS), ribonucleic acid (RNA), capillary isoelectric focusing (cIEF) and glycan characterization analysis, enabling uncompromised accuracy for large sample sets and faster time to answers.

Overcome QTOF MS/MS duty cycle deficiencies

Expand

Take on multiple molecules and multiple applications in less time—all on a single platform.
Tunable fragmentation of all molecule types

Accelerate

Shorten time to market with high-throughput, 8-capillary analytics.
MS/MS scan rates of up to 133Hz

Simplify

With user-friendly software and pre-packaged reagents, running applications on the the BioPhase 8800 system is quick and easy.

Explore the BioPhase 8800 system.

Delivering consistent, comparable and compliant data at scale across the biologic development continuum, the BioPhase 8800 system provides high-throughput, high-sensitivity analysis for bioprocessing, analytical development and QA/QC, all in a single system.

7500 system 7500 system
Compatability
Acoustic Droplet Ejection (ADE)

Compatability

Convenient 96-well plate format compatible with standard liquid handling systems.

Robustness
Robustness

Robustness

Designed for robustness, hardware and software advances ensure repeatability and increased reliability.

Flexibility
Echo MS probe

Flexibility

Flexible to your workflow requirement, switching between UV and UV-LIF detection is simple and seamless. Integrated detection modules make it easy to go from one assay to the next, without sacrificing consistency or performance.

Software
Software width=

Software

Reimagined software makes getting results quick and easy. Simple drag-and-drop functionality for method and sequence creation complements innovative data analysis, to accelerate characterization from start to finish.

Compatability

Convenient 96-well plate format compatible with standard liquid handling systems.

Robustness

Designed for robustness, hardware and software advances ensure repeatability and increased reliability.

Flexibility

Flexible to your workflow requirement, switching between UV and UV-LIF detection is simple and seamless. Integrated detection modules make it easy to go from one assay to the next, without sacrificing consistency or performance.

Software

Reimagined software makes getting results quick and easy. Simple drag-and-drop functionality for method and sequence creation complements innovative data analysis, to accelerate characterization from start to finish.

Take charge of your development timelines.

Zeno DDA EAD/ CID

Adapt to your ever-changing drug pipeline

Easily handle new and more complex molecules and their analytical challenges.

SWATH Acquisition

Reduce method development time

Shorten the time from start-up to answers using 8 channels combined with validated kits and simplified software.

Zeno MRMHR

Sensitive impurity quantitation you can trust

With high-sensitivity UV and laser-induced fluorescence (LIF) detectors, the BioPhase 8800 system generates results you can trust.

Confident answers at warp speed.

Increase speed to market by making confident decisions quickly, based on sensitive, high-resolution data that you’ve come to trust from SCIEX. This speed of analysis helps retain sample integrity between the first sample and the last—delivering consistent, accurate characterization and quantitation for large sample sets, fast.

BioPhase 8800 driver for Empower software

Take control of your BioPhase 8800 system with Empower Chromatography Data System (CDS) for data integrity compliance. Reduce regulatory risk and maximize method transfer efficiency.

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RNA

The BioPhase 8800 system allows for seamless method transferability and multi-capillary throughput for a multitude of RNA species. The RNA 9000 Purity & Integrity kit with the BioPhase 8800 system combines high-throughput screening with ultra-high resolution analysis of RNA products.

Protein purity

The BioPhase 8800 system provides automated, quantitative and repeatable sizing and purity analysis of proteins using the SCIEX gold standard BioPhase CE-SDS Protein Analysis kit. This kit utilizes a replaceable gel matrix to deliver a high-resolution analysis that keeps pace with your workloads while also minimizing sample prep and processing time.

Charge heterogeneity

The BioPhase 8800 system delivers rapid and reproducible charge heterogeneity analysis via multi-capillary isoelectric focusing (cIEF). Parallel processing of 8 samples simultaneously allows for significant improvements in method development and optimization time when analyzing critical molecule charge variants.

Glycan identification

The BioPhase 8800 system provides parallel processing of eight glycan samples simultaneously, enabling high throughput glycan analysis workflows. With the Fast Glycan Labeling and Analysis kit, data collection in less than one minute per sample with highly robust and exceptional performance shortens development time while providing reliable CQA analysis.

Confident answers at warp speed.

Increase speed to market by making confident decisions quickly, based on sensitive, high-resolution data that you’ve come to trust from SCIEX. This speed of analysis helps retain sample integrity between the first sample and the last – delivering consistent, accurate characterization and quantification for large samples sets, FAST.

analysis-kit

Streamline your workflow.

Validated assay kits simplify operation and minimize user error in core industry applications including CE-SDS protein analysis, cIEF analysis, fast glycan analysis and RNA analysis.

Factory-built, multi-capillary, temperature-controlled cartridges help to ensure maximum data reproducibility.

Resource Library

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  • Technical Notes Technical Notes Application guide
  • New

DNA 20 kb Plasmid and Linear Kit Application Guide

Instructions for sample preparation using the DNA 20 kb Plasmid and Linear Kit, with instructions for data acquisition and data analysis on the BioPhase 8800 system. Includes instructions for data acquisition with the BioPhase 8800 Driver for Empower™

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  • Pharma Pharma Protein purity
  • Technical Notes Technical Notes Technical notes
  • New

One-platform strategy for comprehensive characterization of the bispecific antibody, emicizumab, using the BioPhase 8800 system

Significantly shorten the timeline for assay development while achieving comprehensive characterization of size and charge variants of bispecfic monoclonal antibodies (mAbs) using a multi-capillary platform.

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  • Pharma Pharma Protein purity
  • Technical Notes Technical Notes Technical notes
  • New

Monoclonal antibody CE-SDS purity analysis with the SCIEX low pH SDS sample buffer on the BioPhase 8800 system

Greatly reduce sample processing and analysis time, and achieve excellent CE-SDS repeatability and intermediate precision results based on the IgG profiling of three different biosimilars for drozitumab, infliximab, and adalimumab using the BioPhase 8800 system.

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  • Pharma Pharma Protein purity
  • Technical Notes Technical Notes Technical notes
  • New

Lightning capillary electrophoresis sodium dodecyl sulfate (CE-SDS) workflow for high-throughput analysis of biotherapeutics

Explore a highly robust CE-SDS workflow with excellent intermediate precision, accuracy and no carryover or loss of separation efficiency that is 1.5 times faster than the SCIEX original CE-SDS workflow.

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  • Pharma Pharma Gene therapy
  • Technical Notes Technical Notes Technical notes
  • New

A new approach for high-resolution full and empty AAV capsid analysis utilizing a high-throughput method for comprehensive AAV evaluation on a single CE platform

Discover how to save time and cost while reducing laboratory footprint when analyzing multiple AAV critical quality attributes using a single, mutli-capillary platform.

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  • Pharma Pharma Gene therapy
  • Technical Notes Technical Notes Technical notes
  • New

Characterization of lentiviral vector quality attributes using capillary electrophoresis (CE) platform technology

Mitigate the technical difficulties in characterizing lentiviral vectors for the assessment of multiple quality attributes through a CE platform-based approach.

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  • Pharma Pharma Charge heterogeneity
  • Technical notes Technical notes Technical notes
  • New

A design of experiment (DoE) approach to facilitate capillary isoelectric focusing method development for Hemlibra

Significantly reduce the method development time from weeks to 1 day using a multifactorial DoE approach to facilitate high-speed cIEF method optimization for the bispecfic humanized monoclonal antibody, Hemlibra.

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  • Pharma Pharma RNA
  • Technical notes Technical notes Technical notes
  • New

High-throughput, highly reproducible RNA analysis on the BioPhase 8800 system using the Empower Chromatography Data System (CDS)

Discover how to perform high-throughput and highly reproducible RNA analyses in a compliant environment using the BioPhase 8800 driver for Empower software and the RNA 9000 Purity & Integrity kit.

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  • Pharma Pharma RNA
  • Technical notes Technical notes Technical notes
  • New

Separation of circular RNA from the linear precursor by multi-capillary electrophoresis

Achieve rapid separation of circular RNA species using a high resolution mRNA analysis kit and a high-throughput electrophoresis system.

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  • Pharma Pharma RNA
  • Technical notes Technical notes Technical notes
  • New

mRNA-LNP nucleic acid assessment from distinct formulations by multi-capillary gel electrophoresis

Learn how you can easily achieve robust characterization for in vitro transcribed mRNA utilized for mRNA-LNP synthesis using the BioPhase 8800 system and RNA 9000 Purity & Integrity kit

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  • Application Guide Application Guide Application guide
  • New

BioPhase 8800 system consumables and reagents catalog

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  • Application Guide Application Guide Application guide
  • New

Fast Glycan Labeling and Analysis kit application guide

Instructions for sample preparation using the Fast Glycan Labeling and Analysis kit and for data acquisition and analysis using BioPhase software on the BioPhase 8800 system.

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  • Pharma Pharma Protein purity
  • Application Guide Application Guide Application guide
  • New

BioPhase CE-SDS Protein Analysis kit

Get instructions for sample preparation and data analysis when using the BioPhase CE-SDS Protein Analysis kit.

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  • Pharma Pharma RNA
  • Application Guide Application Guide Application guide
  • New

RNA 9000 Purity & Integrity kit

Get instructions for sample preparation and data analysis when using the RNA 9000 Purity & Integrity kit on the BioPhase 8800 system.

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  • Pharma Pharma Charge heterogeneity
  • Application Guide Application Guide Application guide
  • New

BioPhase Capillary Isoelectric Focusing (cIEF) kit

Get instructions for sample preparation and data analysis when using the BioPhase Capillary Isoelectric Focusing (cIEF) kit

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  • Pharma Pharma RNA
  • Technical Notes Technical Notes Technical notes
  • New

High-resolution characterization of both sgRNA and Cas9 mRNA in a single analysis for CRISPR/Cas9 applications

Discover an efficient and time-saving workflow to assess various critical quality attributes (CQAs) for potential mRNA vaccines and CRISPR reagents using the BioPhase 8800 system and the RNA 9000 Purity & Integrity kit.

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  • Pharma Pharma RNA
  • Technical Notes Technical Notes Technical notes
  • New

Genome integrity analysis of adeno-associated viruses (AAVs)

Evaluate the genome integrity and purity of AAVs irrespective of their serotype in a high-throughput format using the RNA 9000 Purity & Integrity kit with the BioPhase 8800 system. Discover the benefits of high sensitivity and excellent inter-capillary reproducibility.

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  • Pharma Pharma Protein purity
  • Technical Notes Technical Notes Technical notes
  • New

High-throughput multi-capillary SDS gel electrophoresis of proteins

The BioPhase 8800 system utilizes a multi-capillary format to provide high-throughput sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) of proteins, enabling characterization to be performed on multiple samples in parallel and shortening development time.

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  • Pharma Pharma Protein purity
  • Technical Notes Technical Notes Technical notes
  • Featured

Acceleration of method optimization for AAV capsid purity analysis using multi-capillary electrophoresis platform

The ability to perform eight separations in parallel on the BioPhase 8800 system allows for faster processing of samples and overall increased throughput to accelerate method development for adeno-associated viruses (AAVs).

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  • Pharma Pharma Gene therapy
  • Technical Notes Technical Notes Technical notes
  • Most Read

BioPhase 8800 System 21 CFR Part 11 compliance

The BioPhase 8800 system software has the design and features to meet the 21 CFR Part 11 compliance and regulatory requirements for operation.

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  • Pharma Pharma Charge heterogeneity
  • Technical Notes Technical Notes Technical notes
  • Featured

Rapid and reproducible parallel processing of charge heterogeneity analysis of protein therapeutics by multi-capillary isoelectric focusing

The BioPhase 8800 system offers a solution to the limited throughput that current single-capillary cIEF systems provide. The new multi-capillary system enables parallel isoelectric focusing analysis for up to 8 samples at a time, allowing for rapid charge heterogeneity analysis of protein therapeutics.

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  • Pharma Pharma Gene therapy
  • Technical Notes Technical Notes Technical notes
  • Featured

Amplification-free analysis of lentiviral vector genome integrity on BioPhase 8800 system

Accelerate analysis time and potentially speed up lentiviral vector (LV)-related product development processes for gene therapy with high-throughput genome integrity analysis of multiple LVs simultaneously on the BioPhase 8800 system.

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  • Pharma Pharma Protein purity
  • Technical Notes Technical Notes Technical notes
  • Featured

CE-SDS analysis of Etanercept using BioPhase 8800 system

Accelerate method development for protein analysis with the multi-capillary separation on the BioPhase 8800 system by simultaneously analyzing multiple Etanercept samples prepared under different conditions and assessing the consistency of deglycosylation reactions in other lots.

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  • Pharma Pharma Glycan identification
  • Technical Notes Technical Notes Technical notes
  • New

Reproducibility study of a high-throughput released N-glycan workflow

This technical note demonstrates the robustness and consistency of the high-throughput analysis of APTS-labeled N-linked glycans by capillary electrophoresis (CE) with laser-induced fluorescence (LIF) detection. The inter- and intracapillary reproducibility validation using the BioPhase Fast Glycan Labeling and Analysis kit yielded 576 data points from 2 instruments, 2 cartridges and 3 chemistry kits.

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  • Pharma Pharma Glycan identification
  • Technical Notes Technical Notes Technical notes
  • New

Released N-linked glycan analysis employing automated sample preparation on a Biomek i5 liquid handler

This technical note presents a streamlined N-linked glycan analysis that employs an automated sample preparation with the magnetic bead-mediated glycan workflow followed by capillary electrophoresis (CE). The inter- and intra-capillary reproducibility results demonstrate the robustness of the assay with automated sample preparation.

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  • Pharma Pharma Glycan identification
  • Technical Notes Technical Notes Technical notes
  • New

High-throughput released N-glycan identification using CE and a customizable glycan library

This technical note demonstrates the procedures for a highthroughput N-linked glycan identification using the new BioPhase Fast Glycan Labeling and Analysis kit with the BioPhase 8800 system. This kit allows customers to achieve large-scale N-glycan profiling with streamlined sample preparation. The user-friendly BioPhase 8800 software empowers customers to customize molecule-specific glycan libraries, which can be employed in a platform separation method.

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