Post translational modifications can occur at every step of the manufacturing process. These modifications can have an effect on a molecule’s charge states and effect a molecule’s potency. Identifying these charge variants is required as a regulatory release assay. CZE (Capillary Zone Electrophoresis) makes charge variant analysis easier then ever before. In under 5 minutes of separation time, the CZE Rapid Charge Variant Analysis Kit can resolve a native state molecule’s charge variants with little-to-no method development and provide more resolution than icIEF or ion exchange chromatography.
Charge variant analysis in as little as 5 minutes
Fast and simple charge heterogeneity – CZE Rapid Charge Variant Analysis Kit
Simplify your charge variant analysis
Fast identification maximizes your lab time
SCIEX CZE Rapid Charge Variant Analysis Kit provides all of the necessary reagents to analyze a molecule’s charge variants based on its mobility. This widely applicable method provides a fast, powerful separation used to quantify charge variants with a buffer that serves as both a separation matrix and dynamic coating with a bare fused silica capillary. In addition, no sample dilution buffer is required; simply dilute the sample in water and you are ready for your separation. SCIEX CZE Rapid Charge Variant Analysis Kit offers an out of the box solution widely applicable for charge heterogeneity analysis.
- CZE Rapid Charge Variant Separation Buffer, 125 mL
- Acid Wash/Regenerating Solution, 100 mL
- CE Grade Water (H2O), 140 mL
- Protein Test Mix, 1 vial
CZE Rapid Charge Variant Analysis Kit
The SCIEX CZE Kit provides a fast and simple separation used to quantify charge variants with a buffer that serves as both a separation matrix and dynamic coating with a bare fused silica capillary. No sample buffer is required; simply dilute the sample in water and you are ready for your analysis.
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PA 800 Plus Pharmaceutical Analysis System
The PA 800 Plus Pharmaceutical Analysis System is a robust analytical platform that provides characterization of product purity, charge heterogeneity and glycan analysis, to help you with the development and quality control of therapeutic proteins.
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Common EZ-CE Cartridge
No need to inventory multiple cartridge types. One EZ-CE cartridge (part # A55625) for Purity, Rapid Charge Variant Analysis, and Fast Glycan Analysis
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Learning Center
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Document
CZE Kit Application Guide
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Technical note
Native State Charge Variant Analysis of Commercialized Monoclonal Antibodies in Minutes
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Technical note
Subunit charge variant characterization in the native state
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Technical note
Rapid charge heterogeneity analysis of new therapeutic protein modalities
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Document
CZE Rapid Charge Variant Analysis Kit
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Webinar
Simple and fast charge variants analysis of mAbs
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Webinar
Charge Heterogeneity Analysis of Biologics by High Resolution cIEF and High Throughput CZE Methods
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Technical note
mAb Charge Heterogeneity Analysis by CZE Part 3: A Test Method Fit for QC Testing
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Technical note
mAb Charge Heterogeneity Analysis by CZE Part 2: A case Study from Merck Sharp and Dohme
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Technical note
mAb Charge Heterogeneity Analysis by CZE Part 1: Results of an Intercompany Robustness Study
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Document
CZE Capillary Conditioning
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Document
CZE Rapid Charge Variant Analysis
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Document
CZE Shutdown
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Document
CZE Analysis