Set the pace with confidence. Cell line monitoring and analysis solutions verify the identity, purity and stability of lead candidates with high throughput strategies that are ready for automation.
Cell line monitoring and analysis
Explore the latest and trending topics
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Technical note
Comprehensive quantification of the components in cell culture media
Characterize a broad range of compounds present in cell culture media using ultra-sensitive MRM methods. Substantially improve detection and quantification of low-level targets.
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Webinar
Facilitate clone selection with high-throughput glycan profiling
Discuss high-throughput strategies for glycan analysis that can condense development timelines.
Overview
Cell-line monitoring throughout drug development helps ensure quality in the biotherapeutic.
Gain the advantage of knowledge up front, with rapid, sensitive, and accurate cell line analysis strategies.
Capillary electrophoresis (CE) and mass spectrometry (MS) workflows address the need for speed, while providing accurate, quantitative information on cell culture media components and cell line stability.
Fast cell-line screening with CE
Workflow
Charge ahead to find candidates that make it to market.
Characterize critical properties, address throughput challenges and gain valuable quantitative data on cell-line samples with automation-friendly capillary electrophoresis (CE) workflows.
High-throughput purity, charge heterogeneity and N-glycan analysis CE workflows provide speed, reproducibility and resolution for product characterization during process and cell-line development.
- Enable quick, easy assessment of product quality
- Minimize sample preparation and method development
- Work toward automation with simple to integrate multi-channel formats
- Software templates optimized for peptide mapping and PQA selection
- Reduce regulatory risk with direct control through the Empower Chromatography Data System
Resources
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Technical note
Eliminate the bottleneck for drug purity analysis with high-throughput rapid CE-SDS purity analysis
Screen a large number of clones for lead clone selection with an automation friendly multi-capillary CE-SDS workflow.
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Technical note
Accelerate cIEF method development from days to hours
Streamline evaluation of multiple factors and post-translational modifications in a single set of experiments with a multifactorial DoE approach
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Technical note
Enable a streamlined, accurate and high-throughput glycan analysis assay
High-throughput glycan expression profiling with automation friendly sample preparation and labeling.
Fast cell-line screening with CE
Suited for:
- High-throughput purity analysis
- IRapid CE-SDS assay
BioPhase 8800 system
Purpose-built for the biopharmaceutical scientist for efficiency and quality, enabling multiple samples to be run in parallel.
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BioPhase CE-SDS Protein Analysis kit
Effective quantification and determination of protein purity and size.
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Fast cell-line screening with CE
Suited for:
- High-throughput charge heterogeneity analysis
- Rapid CE-SDS assays
BioPhase 8800 system
Purpose-built for the biopharmaceutical scientist for efficiency and quality, enabling multiple samples to be run in parallel.
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BioPhase Capillary Isoelectric Focusing (cIEF) kit
Experimental protein isoelectric focusing point (pI) and analysis of charge variants.
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Fast cell-line screening with CE
Suited for:
- High throughput N-linked glycan analysis
- Rapid glycan expression profiling
BioPhase 8800 system
Purpose-built for the biopharmaceutical scientist for efficiency and quality, enabling multiple samples to be run in parallel.
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BioPhase Fast Glycan Labeling and Analysis kit
Release and label glycoprotein N-linked glycans for high-resolution capillary electrophoresis using laser-induced fluorescence (LIF) detection and an HR-NCHO separation matrix.
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Monitoring of target CCM compounds with LC/MS
Workflow
Gain qualitative understanding of cell culture media (CCM) components.
Comprehensive information on CCM components sets the stage for success by helping to ensure optimal CCM conditions and the overall quality of the biotherapeutic.
LC-MS workflows designed to address the wide range of polarities and separation properties of CCM compounds provide a highly sensitive method to monitor target analytes in a single run.
- Improve detection and quantitation limits of low-level analytes
- Save sample and reduce matrix effect with less injection volume
- Identification and quantitation of over 110 compounds in a single run
Monitoring of target CCM compounds with LC/MS
Suited for:
- High-throughput monitoring of CCM compounds
- Identification of targeted CCM compounds
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
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SCIEX 7500 system
Detect the previously undetectable and quantify at lower levels than ever before with impressive precision.
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SCIEX OS software
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
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All resources
Filter:
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Technical note
Take charge of your project timelines
Assess molecular liabilities more quickly with the BioPhase 8800 system, allowing rapid developability assessment to streamline the selection of candidates.
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Technical note
Reproducible glycan analysis for clone selection
Enable reproducible separation of a 96-well plate in under 2 hours.
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Technical note
Streamline CE-SDS workflows with kitted reagents and parallel processing
Significantly improve throughput and process 96-well plates in 12 hours with reproducible separation between instruments and kits.
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Technical note
Eliminate labor-intensive benchwork and provide a higher throughput in N-linked glycan analysis
Streamlined N-linked glycan analysis that employs an automated sample preparation with a magnetic bead-mediated glycan workflow followed by capillary electrophoresis (CE).
-
Webinar
Facilitate clone selection with high-throughput glycan profiling
Discuss high-throughput strategies for glycan analysis to condense development timelines.
-
Technical note
Eliminate the bottleneck for drug purity analysis with high-throughput rapid CE-SDS purity analysis
Screen a large number of clones for lead clone selection with an automation friendly multi-capillary CE-SDS workflow.
-
Technical note
Accelerate cIEF method development from days to hours
Streamline evaluation of multiple factors and post-translational modifications in a single set of experiments with a multifactorial DoE approach.
-
Technical note
Enable a streamlined, accurate and high-throughput glycan analysis assay
High-throughput glycan expression profiling with automation friendly sample preparation and labeling.
-
Technical note
Identify over 110 compounds in under 20 mins
Improve detection of low-level target analytes with a single method.
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Technical note
In-depth profiling of metabolites in CCM
Follow quantitative trends to demonstrate cell growth behavior at different stages of development.
Associated applications
Charge heterogeneity analysis
Pursue the end goal with confidence. Achieve the full picture and accelerate decisions with comprehensive characterization of biopharmaceutical charge variants.
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Glycan analysis
Fully understand drug candidate glycoprofiles with pipeline-specific solutions. Gather critical high-resolution information and site-specific data points with advanced glycan analysis for complex biologic development.
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