The SCIEX clinical diagnostic portfolio is For In Vitro Diagnostic Use. Rx Only. Product(s) not available in all countries. For information on availability, please contact your local sales representative or refer to https://sciex.com/diagnostics. All other products are For Research Use Only. Not for use in Diagnostic Procedures.
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When working with a mAb, you need to know the different charge variants to determine identity and stability. You also need the utmost confidence in your results, as the success of your biologic can depend on the accuracy of your results.
Whether you have several methods to develop, samples to QC with limited resources or labs around the world that all need to use the same methods, you need a solution that you can trust. You need to develop charge heterogeneity methods with high resolution and precision that are fast and easy to use, as well as easily transferable across the globe.
The SCIEX PA 800 Plus allows you to confidently assess charge heterogeneity with ultra-high resolution (CIEF) or simplify your sample preparation (CZE). The PA 800 Plus simplifies your workflows and streamlines your methods so you can improve lab productivity and performance. The system also provides you with the raw data required for regulatory acceptance.
Labs that need to analyze mAbs for identity and stability can rapidly obtain high resolution charge heterogeneity information with simple sample preparation, using CZE. You can also develop methods with high resolution and precision, that are fast and easy to use, as well as easily transferable across the globe.
For maximum sensitivity, ultra-high-resolution capillary isoelectric focusing (cIEF) is capable of achieving separation between isoforms as closely related as 0.03 pI units. The SCIEX cIEF workflow on the PA 800 Plus System has proven robustness and portability. Universal or platform methods can also be created – significantly decreasing method development efforts, simplifying workflows with a single method for molecules across a wide pI range.
For research use only. Not for use in diagnostic procedures.
Capillary zone electrophoresis (CZE) results in faster separation compared to liquid chromatography, reduced sample preparation complexity, and minimal required optimization – all with high reproducibility.
For maximum resolution, capillary isoelectric focusing (cIEF) is capable of achieving separation between isoforms as closely related as 0.03 pI units.
Watch the Webinar: Charge Heterogeneity Analysis of Biologics by High Resolution cIEF and High Throughput CZE Methods
Video Length 57:03
Methods for Particular pH Ranges Available
Broad pH coverage (3-10) in a single run means you run fewer batches
Be confident in your results with reproducible, highly accurate pI determination
Save time with fast, simple sample preparation.
Screen charge variants in about 10 minutes.
Use the same method over a wide range of pI.
The Advanced cIEF Starter Kit helps you get the highest level of precision for pI determination and isoform quantitation of your sample.
With an inventory of just the EZ-CE cartridge you can run CE-SDS, Fast Glycan, and Rapid Charge Variant analyses.
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