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Differential mobility spectrometry (DMS) and
ion mobility spectrometry are analytical techniques used to separate
ions based on their gas phase mobility. Multiple types of ion
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asymmetric waveform devices. Learn how you can separate yourself
Differential Ion Mobility.
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across all MS platforms, from Triple Quad to QTRAP and QTOF.
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and protein bioanalysis
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and non-targeted screening data on your complex samples, faster and
easier than ever before.
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protein digestion solution
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protein assay - human induction kit
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glycan analysis and labeling for the PA 800 plus
standards kit for pesticide analysis
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When working with a monoclonal antibody, you need to know the different charge variants to determine identity and stability. You also need the utmost confidence in your results, as the success of your biologic can depend on the accuracy of your results.
Whether you have several methods to develop, samples to QC with limited resources or labs around the world that all need to use the same methods, you need a solution that you can trust. You need to develop charge heterogeneity methods with high resolution and precision that are fast and easy to use, as well as easily transferable across the globe.
The SCIEX PA 800 Plus allows you to confidently assess charge heterogeneity with ultra-high resolution (CIEF) or simplify your sample preparation (CZE). The PA 800 Plus simplifies your workflows and streamlines your methods so you can improve lab productivity and performance. The system also provides you with the raw data required for regulatory acceptance.
Capillary zone electrophoresis (CZE) results in faster separation compared to liquid chromatography, reduced sample preparation complexity, and minimal required optimization – all with high reproducibility.
For maximum resolution, capillary isoelectric focusing (cIEF) is capable of achieving separation between isoforms as closely related as 0.03 pI units.
Watch the Webinar: Charge Heterogeneity Analysis of Biologics by High Resolution cIEF and High Throughput CZE Methods
Explore the wide selection of capillary electrophoresis-mass spectrometry (CE-MS) solutions that SCIEX offers to solve your challenges for next-generation biotherapeutics, from early discovery through development.
Labs that need to analyze mAbs for identity and stability can rapidly obtain high resolution charge heterogeneity information with simple sample preparation, using CZE. You can also develop methods with high resolution and precision, that are fast and easy to use, as well as easily transferable across the globe.
Save time with fast, simple sample preparation.
Screen charge variants in about 10 minutes.
Use the same method over a wide range of pI.
Flexible platform for multiple analytical assays with a temperature controlled capillary for the utmost reproducibility.
With an inventory of just the EZ-CE cartridge you can run CE-SDS, Fast Glycan, and Rapid Charge Variant analyses.
Charge variant analysis has never been easier. No sample buffer is required; simply dilute the sample in water and you are ready for your separation.
Intercompany Study to Evaluate the Robustness of CZE Technology for the Heterogeneity Analysis of mAbs
MAb charge heterogeneity analysis - A case Study from Merck Sharp & Dohme
MAb charge heterogeneity analysis - A Test Method Fit for QC Testing
Simple and fast charge variants analysis of mAbs by CZE with Dr. Yan He from Pfizer
For maximum sensitivity, ultra-high-resolution capillary isoelectric focusing (cIEF) is capable of achieving separation between isoforms as closely related as 0.03 pI units. The SCIEX cIEF workflow on the PA 800 Plus System has proven both robust and portable. Universal or platform methods can also be created – significantly decreasing method development efforts and simplifying workflows with a single method for molecules across a wide pI range.
Methods for Particular pH Ranges Available
Broad pH coverage (3-10) in a single run means you run fewer batches
Be confident in your results with reproducible, highly accurate pI determination
pI Marker Kit features synthetic peptides for high resolution and quantitative reproducibility in calculating protein pI.
Identification of System Parameters Critical for High-Performance cIEF
High-Resolution cIEF of Therapeutic Monoclonal Antibodies: A Platform Method Covering pH 4-10
A Robust cIEF Method: Intermediate Precision for the pH 5-7 Range
Achieving Robust cIEF Analysis of Monoclonal Antibodies While Increasing Capillary Run-Life and Maintaining High Resolution
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