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The M5 MicroLC is a feature rich microflow LC-MS solution meant to simplify both small and large molecule quantitation and characterization. In addition to using a small sample size, this extremely sensitive, versatile instrument will help you save on costs, space, and fully integrates with your SCIEX mass spectrometer of choice.
The M5 MicroLC is the perfect balance of sensitivity and robustness—more sensitive than traditional analytical flow LC and more flexible and more robust than nanoflow LC — giving you the potential to optimize your biopharma workflows, today and into the future.
Microfluidic control for accurate flow down to 1 µL/min. Quantitate with up to a 10x sensitivity improvement
Easily customizable and compatible with any micro column, you can switch between assays for an unlimited number of potential drug candidates
Trap-and-Elute option with additional gradient pump for fast sample loading
With flow rates as low as to 1 µL/min to boost signal, and with vial bottom-sensing technology, you can now get more from your limited sample
Experience the greater sensitivity, flexibility, and robustness with the advanced technology in the M5 MicroLC.
Compared to analytical flow, the lower flow rate range of the M5 MicroLC delivers a higher percentage of ions into the mass spectrometer so you get greater sensitivity for your precious samples.
Get dual flow path capability by adding a second gradient pump – Cutting analysis time by giving you the option of taking the trap offline.
Know your connections are perfect with finger-tight, no tool fittings. Just listen for the click, and you are good to go.
Patented Microfluidic Flow Control™ technology allows you to get consistent, accurate results without flow splitting.
The M5 MicroLC LC-MS instrument is engineered to give you maximum performance, flexibility and robustness for your workflow of choice.
See how we can put the M5 MicroLC to work for you.
Reach your required LLOQ by achieving up to 10x more sensitivity.
Vial-bottom sensing technology helps you get the most from your limited samples.
Easily customizable, you can use any column, and any chemistry to switch between assays for an unlimited number of potential drug candidates.
Reduce your cost per sample with up to 125x less solvent consumption so you can minimize purchase, storage, and disposal costs.
The adoption of LC-MS system is becoming more desirable in today’s laboratories due to its high selectivity, accuracy, and precision for analyzing bioanalysis candidates. The M5 MicroLC offers a complete solution to optimize your biologic workflows, today and into the future.
Quantify signature peptides or therapeutic peptides in complex matrices, such as serum and plasma.
Targeted antibody quant with outstanding sensitivity and linear dynamic range.
Accelerate bioanalytical method development for ADCs with high-sensitivity assays for antibody and/or drug payload.
Enhance small molecule and metabolite analysis with microflow sensitivity.
|Space Saving||Stackable on your SCIEX 6500+ to maximize floor space|
|Customizable||Choose the columns you need to accomplish your goals|
|Integrated Solutions||Pair with SCIEX Mass Spectrometers and Analyst® software|
|Maximize Uptime||Utilize trap-and-elute workflow for increased robustness|
|Easily Implemented||Ready to work with your existing Turbo V Source or OptiFlow™ Turbo V Source|
Discover the benefits of moving to MicroFlow. From increased sensitivity and using less sample to cost savings, see how MicroFlow is the right solution for you.
Pair your M5 MicroLC with specially designed columns and industry-leading mass spectrometers for maximum sensitivity for your most challenging applications.
Designed and optimized for SCIEX's microLC systems, our columns operate at high linear flow velocities to ensure optimal performance at faster speeds and higher throughput levels.
Combine our M5 MicroLC system, with industry-leading mass spectrometers for increased sensitivity and robustness across a wide range of applications.
Gain all the sensitivity benefits of moving to microflow rates, without sacrificing the robustness and usability you’ve come to expect from traditional analytical flow assays.
Technical Note: Improve quantitation of total antibody-drug conjugates (ADCs)
Technical Note: Support a growing class of new drug molecules using robust bioanalytical methods
Technical Note: Gain accurate and highly sensitive characterization and quantitation of intact monoclonal antibodies
Technical Note: Use a combination of immunocapture-based target enrichment and trap-and-elute microflow LC-MS/MS for analyzing and studying insulin glargine in biological samples
Technical Note: Microflow Chromatography Provides Improved Sensitivity and Coverage of Polar Metabolites for Targeted Metabolomics - Complete Workflow
Webinar: Increase your metabolome coverage with only a quarter the effort
M5 MicroLC System Training
|MicroFlow MoGraph Series 4 Use Up To 5x Less Standard||12/17/2018|
|MicroFlow MoGraph Series 5 Greater Flexibility||12/17/2018|
|MicroFlow MoGraph Series 6 Continuous Operation||12/17/2018|
|MicroFlow MoGraph Series 3 Use Up To 250x Less Solvent||10/19/2018|
|MicroFlow MoGraph Series 1 Greater Sensitivity||10/12/2018|
|MicroFlow MoGraph Series 2 Less Sample Needed||10/12/2018|
|M5 MicroLC Systems Operator Guide||06/20/2018|
|M5 MicroLC and M5MicroLC-TE Specifications||04/15/2018|
|Why move to Optiflow||02/10/2018|
|Analysis of Intact Monoclonal Antibodies Using an M3 MicroLC with the TripleTOF 6600||01/05/2018|
|Bioanalysis Quantitation Applications eBook||09/25/2017|
|Advanced Biotransform Solution: Sensitive Microflow Analysis of Peptide Catabolism||09/15/2017|
|Robust and Sensitive Workflow for Qualitative and Quantitative Analysis of Intact Monoclonal Antibodies Using Microflow LC and TripleTOF Mass Spectrometry||06/25/2017|
|SCIEX Quantitation and Metabolism Solutions Brochure||05/26/2017|
|Why SCIEX Microflow||03/10/2017|
|Sensitive and Accurate Quantitation of the Antibody-Drug Conjugate Ado-Trastuzumab Emtansine in Rat Plasma||01/10/2017|
|Quantitation of Insulin Glargine in Human Plasma||12/15/2016|
|Using Microflow LC–MS for Top-Down Sequencing and Bottom-Up Peptide Mapping||12/12/2016|
|Throughput and Sample Preparation Improvements for Endocrine Research by Micro-flow LC-MS/MS||10/14/2016|
|Sensitive Quantitation of Glucagon in Rat Plasma with Trap-and -Elute MicroLC-MS||07/20/2016|
|Novel Targeted Metabolic Profiling Workflow for Simultaneous Reverse Phase and Normal Phase LC-MS/MS Analysis on a M3 MicroLC System||06/06/2016|
|Improving Sensitivity in Bioanalysis Using Trap-and-Elute MicroLC-MS||06/06/2016|
|Improving Quantitative Sensitivity for Monoclonal Antibodies with the M3 MicroLC||04/26/2016|
|新製品M3 Micro LC||03/15/2016|
|Improving Sensitivity in Bioanalysis using Trap-and-Elute MicroLC-MS||01/25/2016|
|Improving Sensitivity for an Immunocapture LC-MS Assay of Infliximab in Rat Plasma Using Trap-and-Elute MicroLC-MS||01/10/2016|
|Improving Sensitivity in Bioanalysis using Trap-and-Elute MicroLC-MS||12/18/2015|
|Rapid Quantitation of Substance P in Plasma using Differential Mobility Spectrometry and Micro Flow Liquid Chromatography||12/01/2015|
|Novel High-Throughput Microflow UHPLC Method for LC-MS/MS Quantitation||06/01/2015|
|Comprehensive workflow solutions to quantify biotherapeutics by LC-MS|
|Microflow LC applications with a focus on peptide quantification|
|Determination of therapeutic oligonucleotides using LC-MS|
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