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spectrometer. SCIEX has the broadest portfolio of ESI-MS front-ends
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flow, microflow, nanoflow LC-MS and even ultra-low flow
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Differential mobility spectrometry (DMS) and
ion mobility spectrometry are analytical techniques used to separate
ions based on their gas phase mobility. Multiple types of ion
devices exist, such as drift tubes, traveling wave, and high-field
asymmetric waveform devices. Learn how you can separate yourself
Differential Ion Mobility.
The latest ion sources from SCIEX enable
enhanced sensitivity and robustness with greater desolvation range
across all MS platforms, from Triple Quad to QTRAP and QTOF.
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vMethod applications are pre-configured and verified LC-MS/MS
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details for applicable MS/MS library databases for key applications.
and personal care products (PPCPs)
and protein bioanalysis
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libraries can dramatically enhance the quality of your analysis,
you much improved confidence in your data. With a comprehensive
at your fingertips, you can easily create methods and process
and non-targeted screening data on your complex samples, faster and
easier than ever before.
All in one
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Boost the performance of your mass
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iChemistry Solutions are the world's only reagents and
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RNA 9000 Purity & Integrity kit
kit for amino acid analysis of hydrolysates
kit for amino acid analysis of physiological fluids
protein digestion solution
Biologics analysis kit for
protein assay - human induction kit
CZE rapid charge variant analysis kit
glycan analysis and labeling for the PA 800 plus
standards kit for pesticide analysis
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From substantiating new discoveries through
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data that you can genuinely count upon. With a portfolio of
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with best-in-class hardware, software and support all integrate to
revolutionize your lab.
Native Mode Analysis
Nucleic Acid and Plasmid Analysis
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Capillary electrophoresis sodium dodecyl sulfate (CE-SDS) is the only way to obtain automated, quantitative purity data (i.e. glycosylated vs non-glycosylated) on both intact and reduced monoclonal antibodies. It is quantitative, automated and fast.
CE-SDS data acquired by some technologies is regularly manipulated and enhanced. This may mask weaknesses in hardware and chemistries, and more importantly data quality. Only raw, unprocessed data can provide the confidence critical to both you and the regulatory for product submission and commercialization.
Only SCIEX CE technology uses circulating liquid temperature control to maximize data quality preventing the need for any data enhancement and manipulation. Additionally, our technology supports a wider range of method options.
In addition to quantitative data, automation, and full method development flexibility, the following benefits of SCIEX CE-SDS technology provide the critical confidence that you seek in your purity analysis from analytical development to QC.
The SCIEX CE-SDS proprietary replaceable gel technology, , is referenced in USP chapter <129>  and the application is recommended by a published intercompany collaboration.
Patented circulating liquid cooling of the capillary provides reproducible data that requires no enhancements nor manipulations. SCIEX CE-SDS always gives you secure raw data that better quantitates low MW species.
Modular PDA or laser-induced fluorescence detection provides at least three orders of magnitude of impurity detection – 0.1% and 0.01% respectively.
The fastest separation without sacrificing resolution (12 min reduced, 18 min. non-reduced).
SCIEX CE-SDS offers detection with PDA or LIF and two validated chemistry kits.
Part # A10663
Component Quantity/Amount. Capillary, 50 μm I.D. bare-fused silica 2. SDS-MW Gel Buffer - proprietary formulation, pH 8, 0.2% SDS 140 mL. SDS-MW Sample Buffer - 100 mM Tris-HCl, pH 9.0, 1% SDS 50 mL. IgG Control Standard 1 mL. Internal Standard, 10 kDa protein, 5 mg/mL 0.4 mL. Acidic Wash Solution, 0.1 N HCl 100 mL. Basic Wash Solution, 0.1 N NaOH 100 mL.
Part # 390953. Component Quantity/Amount. Capillary, 50 μm I.D. bare-fused silica 2. SDS-MW Gel Buffer - proprietary formulation, pH 8, 0.2% SDS 140 mL. SDS-MW Sample Buffer - 100 mM Tris-HCl pH 9.0, 1%SDS 50 mL SDS-MW Size Standard (10 to 225 kDa, 16 mg/mL) 100 μL. Internal Standard, 10 kDa, protein 5mg/mL 0.4 mL. Acidic Wash Solution (0.1 N HCl) 100 mL. Basic Wash Solution (0.1N NaOH) 100 mL.
For ultimate sensitivity in impurity detection, upgrade to Laser Induced Fluorescence (LIF) detection. This upgrade (part # A59494) requires a PA 800 Plus or CESI 8000 Plus. This package consists of a durable solid-state laser and detector that can easily be switched with the PDA detection set-up.
The PA 800 Plus Pharmaceutical Analysis System is a robust analytical platform that provides characterization of product purity, charge heterogeneity and glycan analysis, to help you with the development and quality control of therapeutic proteins.
No need to inventory multiple cartridge types. One EZ-CE cartridge (part # A55625) for Purity, Rapid Charge Variant Analysis, and Fast Glycan Analysis
. Gel US Patent # US7,381,317. Automating the process of gel replacement is disclosed in US.
. Patent # USRE37,606.
. Chemistries referenced in USP Chapter <129>.
. A Series of Collaborations between Various Pharmaceutical Companies and Regulatory Authorities Concerning the Analysis of Biomolecules Using Capillary Electrophoresis.” Chromatographia 2006, 64, September (No. 5/6).
. The PA 800 Plus ensures requirements of 21CFR211.194 can be met by providing raw, unmanipulated data.
. US Patent 5,198,091.
. USP Chapter <129> Analytical Procedures for Recombinant Therapeutic Monoclonal Antibodies.
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