Optimize your processes with solutions that overcome the analytical challenges of viral vector-based drugs.
Take control of full and empty ratios and protein and genome profiles. Break down the boundaries of protein and post-translational modification (PTM) characterization with dedicated high-resolution workflows offering unprecedented depth.
The development of viral vector vaccines and therapeutics means overcoming many challenges.
Intuitive, innovative and informative analytical solutions for viral-vector characterization help ensure safe and effective drugs and let you stay focused.
Work with an evolving partner to realize the full potential of using viral vectors—such as adenoviruses (AVs), adeno-associated viruses (AAVs) and lentiviruses (LVs)—and virus-like particles as delivery vehicles for nucleic acid-based gene therapies and vaccines.
Workflow
Viral vector characterization for vaccine and therapeutic drug development includes assessing multiple critical quality attributes (CQAs). This can be a cumbersome task, especially when different serotypes require assay adjustments.
Save time by characterizing multiple CQAs with serotype-independent workflows on a single platform. The ability to determine viral protein profiles, genome integrity, nucleic acid impurities, titer and full and empty ratios with high sensitivity on a user-friendly system lets you move your viral vector programs forward with confidence.
Suited for:
Purpose-built for the biopharmaceutical scientist for efficiency and quality, enabling multiple samples to be run in parallel.
Purity and integrity analysis of RNA therapeutics, vaccines and single stranded oligos.
Effective quantification and determination of protein purity and size.
Pre-assembled bare-fused silica 8-capillary cartridge for the BioPhase 8800 system - 8 x 30 cm. (P/N 5080121)
Webinar
A new, versatile approach for high resolution full and empty AAV analysis
Learn how to break through the boundaries of critical quality attribute (CQA) determination of adeno-associated viruses (AAVs) using a single platform. Leverage high-resolution data to push your viral vector development forward with platform methods.
Technical note
Genome integrity, protein profiling and full and empty ratio assessment of AAV on a single CE platform
Reach new milestones by assessing adeno-associated virus (AAV) critical quality attributes (CQAs) on an intuitive platform that provides sensitive, high-quality data for multiple viral-vector quality attributes.
Suited for:
Characterize therapeutic molecules with confidence with the kit-based system.
Purity and integrity analysis of RNA therapeutics, vaccines and single stranded oligos.
Effective quantitation and determination of protein purity and size.
Pre-assembled bare-fused silica capillary cartridge for the PA 800 Plus system.
Featured resources
Technical note
Purity analysis of AAV capsid proteins
Set new frontiers for protein profiling and protein purity assessment of AAVs with an intuitive solution that provides accurate and sensitive and informative data.
Technical note
High-precision lentivirus titer determination and protein profiling
Take control of the quality of your lentiviral vectors with high-performance solutions. Learn how to characterize proteins, determine protein profiles and enhance your understanding of process changes with intuitive workflows.
Workflow
Viral capsid proteins can impact uptake by cells and therefore directly impact their effectiveness. Thorough protein characterization helps ensure the quality of your viral vectors.
Assess capsid protein integrity through high-quality data coupled with powerful intact mass deconvolution and elucidate the identities and positions of challenging post-translational modifications (PTMs) that can impact safety and efficacy.
Move beyond boundaries of low sample amounts with highly sensitive workflows.
Suited for:
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
Be empowered with highly accurate and informative workflows for fully characterizing protein therapeutics and viral vector proteins.
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Suited for:
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
A purpose-built QTOF system, designed specifically to accelerate everyday biologics characterization.
Be empowered with highly accurate and informative workflows for fully characterizing protein therapeutics and viral vector proteins.
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Workflow
The changing landscape of packaging cell lines and the need to combat future pandemics with unprecedented response times require highly adaptable solutions for detecting process-related impurities in viral vector products.
High-quality data from fast scanning solutions provide excellent coverage and depth to identify thousands of low abundance residual host cell proteins without the need for lengthy assay development.
Enable your team to ensure product safety and keep processes moving with confidence.
Solution
Suited for:
Enjoy the perfect balance of sensitivity and robustness with a feature-rich microflow LC solution built for small and large molecule quantitation and characterization.
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
Webinar
A new, versatile approach for high resolution full and empty AAV analysis
Learn how to break through the boundaries of critical quality attribute (CQA) determination of adeno-associated viruses (AAVs) using a single platform. Leverage high-resolution data to push your viral vector development forward with platform methods.
Technical note
Genome integrity, protein profiling and full and empty ratio assessment of AAV on a single CE platform
Reach new milestones by assessing adeno-associated virus (AAV) critical quality attributes (CQAs) on an intuitive platform that provides sensitive, high-quality data for multiple viral-vector quality attributes.
Technical note
Purity analysis of AAV capsid proteins
Set new frontiers for protein profiling and protein purity assessment of AAVs with an intuitive solution that provides accurate and sensitive and informative data.
Technical note
High-precision lentivirus titer determination and protein profiling
Take control of the quality of your lentiviral vectors with high performance solutions. Learn how to characterize proteins, determine protein profiles, and enhance your understanding of process change.
Technical note
Intact protein analysis and peptide mapping of AAV capsid proteins
Uncover a sensitive and easy-to-adopt solution that enables confident identification of low abundance proteins and post-translational modifications (PTMs), including structurally similar isomers that can impact vector infectivity and efficacy.
Technical note
Intact viral protein characterization with powerful time-resolved deconvolution
Discover an innovative way to achieve protein deconvolution with 3-dimensional data visualization. See more and miss fewer relevant features of your sample.
Webinar
Analysis of process-related impurities in cell and gene therapy products
Dr. Ejvind Mørtz (Alphalyse) is changing the paradigm of host cell protein analysis with highly flexible, sensitive and reliable MS solutions. Discover workflows that offer more detailed information on impurities in viral vector products.
Advance your projects with purpose-built solutions for the analysis of plasmid DNA (pDNA) and double-stranded DNA (dsDNA) to support the development of your messenger RNA (mRNA), viral vectors, recombinant proteins and other new modalities.
Optimize workflows to reliably detect and monitor process-related impurities. Ensure the safety of next-generation viral products with accurate, reproducible sizing of residual DNA and RNA and simultaneous quantitation.
Set your own schedule for CRISPR/Cas9 gene editing with innovative, intuitive analytical solutions. Unleash the potential of your Cas9 messenger RNA (mRNA), single guide RNA (sgRNA) and Cas9 proteins by understanding quality, purity and safety and assessing on/off target effects.