September 24-26, 2024
A 3-day live virtual event you won't want to miss
EDT: 10:00 a.m. - 2:00 p.m.
PDT: 7:00 a.m. - 11:00 a.m.
GMT: 3:00 p.m. - 7:00 p.m.
SCIEX summit
Highlighting scientific breakthroughs in mass spectrometry that really count
Join scientists and researchers from around the globe to discuss the importance of LC-MS in fields like food and environmental testing, pharmaceutical and biopharmaceutical discovery and development and biomedical and omics research.
Day one: Innovation and data insights
- Discover how to achieve high sensitivity, speed, and resilience when working with large, complex sample sets
- Learn strategies to speed up your covalent protein drug discovery
- Gain insights into accelerating the development of multiple modalities
- Understand the latest advancements in quantitative proteomics with ZT Scan DIA
- Overcome limitations with cutting-edge artificial intelligence quantitation software
Day two: Characterization and discovery
- Characterize and quantify calreticulin (CALR) arginylation using electron-activated top-down proteomics
- Achieve in-depth profiling of metabolites and lipids in biological samples
- Obtain accurate and reliable metabolite identification using electron-based fragmentation (EAD)
- Detect trace amounts of pesticide residues in food by targeted and non-targeted, IDA and SWATH approaches
- Enhance routine characterization of low-abundant sequence variant (SV) through fast and sensitive EAD-DDA
Day three: Quantitation and screening
- Enhanced sensitivity and robustness deliver stringent quantitation for veterinary drug testing for meat
- See how intuitive, compliant-ready SCIEX OS software enables pharmacokinetic parameter monitoring with ease and reliability
- Understand the challenges and best practices for oligoneucleotide analysis by LC-MS
- Discover how exploiting fast acquisition rates can be used to identify and quantify over 2250 fatty-acids lipids
- Hear about the accurate detection and quantitation of trace-lelvel PFAS compounds
Agenda-at-a-glance
Note: Due to the interactive nature of the live event, start and end times are subject to change. Please log in early.
Meet the moderators
Join us for an engaging 3-day event featuring insights from industry experts, giveaways, and interactive poll questions. Each day will be led by a SCIEX expert, ensuring a dynamic and informative experience.
Day one: innovation and data insights
Jamie Wighton, Senior Director LC-MS Research, SCIEX
Jamie joined SCIEX 20 years ago and has held multiple technical and leadership roles throughout his career at SCIEX. Starting out as an engineer in manufacturing operations, Jamie has since led teams in supply chain, product development, and most recently the research and product applications teams within R&D. Prior to joining SCIEX, Jamie worked at JDS Uniphase as an optical test engineer.
Jamie holds a B.Sc. in engineering physics from Queen’s University.
Day two: characterization and discovery
Tatjana Talamantes, Senior Product Manager, Accurate Mass, SCIEX
Tatjana is a Senior Product Manager at SCIEX, overseeing accurate mass systems since 2021. She collaborates with R&D, sales, and marketing teams to ensure effective project execution and portfolio management.
Previously, Tatjana was a Product Manager at MOBILion Systems, leading the pre-commercialization of SLIM-based ion mobility instruments. She also has held roles at Thermo Fisher Scientific as a Sr. Vertical Marketing Specialist and Sr. Field Applications Scientist.
Tatjana holds a B.A. in chemistry from Austin College and a Ph.D. in biomedical sciences and biochemistry from the University of North Texas Health Science Center.
Day three: quantitation and screening
Ian Moore, Sr. Technical Product Manager, Nominal Mass, SCIEX
With over ten years in product development, Ian is the Senior Technical Product Manager for nominal mass LC-MS/MS systems at SCIEX. He has also served as a Technical Product Manager and Global Technical Marketing Manager. Ian began his SCIEX career as an Application Scientist, focusing on biologics bioanalysis and DiscoveryQuant software validation.
Before SCIEX, Ian was the Lead Analytical Scientist at Custom Biologics, overseeing LC-MS/MS method development and clinical trial analysis. He also served as a Senior Scientist at Affinium Pharmaceuticals, focusing on metabolic stability profiling and enzyme inhibition assays.
Ian holds a postdoctoral position at McMaster University, specializing in antibiotic resistance and enzyme inhibitor screening
Meet the speakers
Biomedical and omics research
Biomedical and omics researchers worldwide rely on cutting-edge LC-MS/MS solutions to meet their dynamic needs. From biomarker discovery to translational research and beyond, SCIEX technology empowers you to delve deeper into the intricacies of biology to uncover crucial insights with unparalleled precision and efficiency.
Expanding qualitative and quantitative sensitivity for immunopeptidomics using ZT Scan DIA
Tony Purcell, Professor, Monash University
Tuesday, September 24
12:05 pm EDT
Learn how utilizing a research-grade Zeno-trap time-of-flight LC-MS system can advance current applications in immunopeptidomics and proteomics, including:
- What is ZT Scan DIA, the technology and how it benefits data acquisition
- Preliminary proteomics and immunopeptidomics results using ZT Scan DIA
- Future applications of immunopeptidomics using ZT Scan DIA
Artificial intelligence quantitation (AI quant): molecular structure and mass spectral data quality driven processing of high-resolution mass spectrometry for quantitative analysis
Kevin Bateman, Retired Pharmacokinetics, Pharmacodynamics and Drug Metabolism Expert
Tuesday, September 24
12:40 am EDT
High-resolution mass spectrometry (HRMS) has long sought to be a viable alternative for quantitative workflows but has been unable to broadly compete, mainly due to the lack of suitable data processing software. In this work we describe:
- A molecular structure-dependent workflow
- The holistic and user-independent processesing of HRMS data
- The automatic quantification of small drug-like molecules
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In-depth metabolomics and lipidomics analyses
Michael Witting, Deputy Head Metabolomics and Proteomics Core and Executive Manager Metabolomics, Helmholtz Munich
Wednesday, September 25
10:55 am EDT
Routine measurement of metabolites and lipids has become a cornerstone of biomedical research. At the MPC, Helmholtz Munich, non-targeted analysis is based on the SCIEX ZenoTOF 7600 for accurate and in-depth analysis and annotation of metabolites and lipids from different biological specimens.
- Application of Zeno trap enabled non-targeted workflows to large scale metabolomics and lipidomics studies
- Enhanced sensitivity enables deeper profiling of biological samples
- Increased confidence in identifications through comprehensive structural elucidation using Electron activated dissociation (EAD)
Top-down characterization of post-translational arginylation using electron activated dissociation (EAD)
Tom Lin, Instructor, Washington University in St. Louis
Wednesday, September 25
10:20 am EDT
Learn about our top-down proteomics workflow for the characterization and quantification of calreticulin (CALR) arginylation. MS1 profile and MS2 fragmentation were characterized by EAD. Preferential fragmentation at the CALR N-terminals yielded sufficient c ions facilitating precise localization of the arginylation sites. Learn about:
- Arginylation regulates CALR degradation and ER function
- EAD is efficient in characterizing N-terminal arginylation
- The workflow sets up the foundation for unbiased top-down activity-based arginylation profiling
Fast scanning quantitative lipidomics analysis using the SCIEX 7500+ system
Paul Baker, Senior Scientific Liason, Lipidomics and Metabolomics, SCIEX
Thursday, September 26
12:00 pm EDT
A panel of >2250 lipids was used to demonstrate the power and capability of the SCIEX 7500+ system to sensitively identify and quantify lipids at the fatty acid level using a multiple reaction monitoring (MRM). HILIC-like chromatography provides class separation to mitigate inter-lipid class isobaric overlap, but means that the speed at which individual MRM transitions are measured is crucial to ensure good coverage and quantitative accuracy.
- The ~4X faster analytical speed of the SCIEX 7500+ system improves the quantitative performance of a large, broadly targeted lipid panel
- The number of lipid molecular species quantified with %CV < 20 increased 59% during a period of the highest MRM concurrency (n = 925) compared to the fastest speed recommended on the SCIEX 7500 system
- The faster MRM acquisition rates improve peak shapes by increasing the number of data points across the peak and providing better resolution of near-eluting lipid isomers
Pharma and biopharma
To bring safe and effective therapies to market, it is vital for pharma and biopharma scientists to have the right information available at every stage of the process. Discover analytical strategies that are advancing pharma and biopharma research through a commitment to innovation, and enabling comprehensive small and large molecule analysis, from discovery to commercialization.
Advancing robustness and serviceability of a high-end triple quad mass spectrometer in a high-throughput bioanalytical lab
Rathna Veeramachaneni, Director, Biopharma LC-MS/MS, KCAS Bioanalytical
Tuesday, September 24
10:20 am EDT
Highly sensitive mass spectrometers allow the advanced bioanalytical labs of today to achieve the LOQ required of potent biologic drugs and provide maximum flexibility in choice of sample prep techniques. However robust mass spectrometers are crucial for several reasons:
- Aid in ensuring the consistent quantitative performance of an assay
- Effectively allow a lab to meet their project timelines
- Are essential for handling the inherent variability of analyzing diverse molecules and diverse samples required for bioanalysis
The new fast in drug discovery: a new MS system to study covalent protein drugs
Markus Stöckli, Senior Principal Scientist, Novartis Institutes for BioMedical Research
Tuesday, September 24
10:55 am EDT
The combination of a super-fast sampling interface with the highly sensitive ZenoTOF 7600 system makes it an ideal system for evaluating covalent binding screens. Main findings in our experiments using the Echo® MS+ system:
- Speed: measurements from a full 384-well plate in 15 min or 1536-well plate in less than one hour
- Precision: low injection volume supports repetitive measurements and time series; capture full kinetic data set in one experiment
- Quality: high data quality allows for full automated processing, delivering immediate hitlist output
icIEF-UV/MS characterization of charge Isoforms for biotherapeutic products
Xiaoping He, Senior Scientst, Pfizer
Tuesday, September 24
11:35 am EDT
Characterization of icIEF charge isoforms, whether in early product development or associated with licensure filings, is usually achieved through ion exchange (IEX) liquid chromatography coupled with mass spectrometry. icIEF-MS technology has recently emerged to enable the direct characterization of specific species in the icIEF electropherogram, eliminating the need for extensive method development.
- Discover opportunities to advance core platform technologies with novel characterization approaches
- Hear case studies on understanding molecular structure information
- New approaches to characterizing post-translational modifications of charge isoforms
Artificial intelligence quantitation (AI quant): molecular structure and mass spectral data quality driven processing of high-resolution mass spectrometry for quantitative analysis
Kevin Bateman, Retired Pharmacokinetics, Pharmacodynamics and Drug Metabolism Expert
Tuesday, September 24
12:40 am EDT
High-resolution mass spectrometry (HRMS) has long sought to be a viable alternative for quantitative workflows but has been unable to broadly compete, mainly due to the lack of suitable data processing software. In this work we describe:
- A molecular structure-dependent workflow
- The holistic and user-independent processesing of HRMS data
- The automatic quantification of small drug-like molecules
MetID innovations in pharma: exploring new avenues for metabolite structure elucidation
Nari Talaty, Principal Research Scientist II, AbbVie
Wednesday, September 25
11:30 am EDT
Check back soon for more details!
Reduce risk and accelerate cell line development with iCIEF-UV/MS technology
Kristen Nields, Principal Scientist, J&J Innovative Medicines
Wednesday, September 25
12:40 pm EDT
Guide decisions during cell line development with the Intabio ZT system with more information on how process changes affect cell line and product stability.
- How to utilize icIEF-UV/MS to identify sequence variants
- How this information can be used to create a mitigation strategy
- What more information in less time means to groups throughout process development
Maximizing analytical potential and navigating changes in the validated laboratory with SCIEX OS software
April Quinn-Paquet, Global Marketing Product Manager, Software, SCIEX
Thursday, September 26
10:50 am EDT
Having the right information available at every stage of the process is vital to bringing safe and effective therapies to market.. SCIEX OS software is a vital component of this process, from discovery to development. See how:
- Your pharma lab workflows can benefit from SCIEX OS software
- Central Admin Console enables comprehensive audit configurations for full traceability
- Professional services are available to assist in migrating from legacy Analyst software and change control support plansis
Approaches for the bioanalytical analysis of oligonucleotide therapies
Shane Karnik, Senior Laboratory Director, Aliri Bioanalysis
Thursday, September 26
11:40 am EDT
Oligonucleotide therapeutics are on the rise in drug development and regulatory submissions. These drugs face challenges with bioanalytical extraction and analytical detection due to their chemical backbone or other stability-enhancing modifications.
- Learn about bioanalytical challenges and best practices for oligonucleotide analysis
- Hear case studies in the quantitation of oligonucleotide therapies using different mass spectrometry platforms
- Gain insights into improved method development for obtaining validated assays for regulatory evaluations using high-resolution mass spectrometry in early-stage development
Food and environmental
From routine applications such as mycotoxins and contaminant quantitation, to trace-level PFAS detection in complex matrices, our food and environmental customers and scientists around the globe are empowered by the combination of sensitive hardware, flexible software, and industrial expertise to enable testing capabilities for comprehensive data collection and report generation.
Artificial intelligence quantitation (AI quant): molecular structure and mass spectral data quality driven processing of high-resolution mass spectrometry for quantitative analysis
Kevin Bateman, Retired Pharmacokinetics, Pharmacodynamics and Drug Metabolism Expert
Tuesday, September 24
12:40 am EDT
High-resolution mass spectrometry (HRMS) has long sought to be a viable alternative for quantitative workflows but has been unable to broadly compete, mainly due to the lack of suitable data processing software. In this work we describe:
- A molecular structure-dependent workflow
- The holistic and user-independent processesing of HRMS data
- The automatic quantification of small drug-like molecules
Time-of-flight mass spectrometry applications in food science: targeted and non-targeted approaches
Francisco José Díaz-Galiano, Postdoctoral researcher, University of Almería
Wednesday, September 25
12:05 pm EDT
Time-of-flight mass spectrometry has become a key tool in analytical laboratories involved in food analyses. This instrumentation can be used for both targeted and non-targeted approaches. In this presentation, we will discuss:
- Overview of practical targeted and non-targeted approaches in food analysis
- Application of a SWATH® approach to the analysis of pesticide residues in food
- Application of IDA approaches in non-targeted food analyses
Veterinary drug analysis: SCIEX 7500 system vs 7500+ system
Claudia Ancillotti, Method Development Manager, BIOCHEMIElab
Thursday, September 26
10:20 am EDT
Biochemie Lab shares their expertise in veterinary drug analysis. With over 25 years of experience and strict adherence to Commission Regulation (EU) No 37/2010, Biochemie Lab processes more than 100,000 samples annually, providing comprehensive food and environmental testing.
- Learn how Biochemie Lab conducts veterinary drug testing with specialized veterinarians, covering a wide range of analyses, including residual veterinary drugs, anabolic substances, and microbiological tests.
- Discover how they overcome challenges in analyzing complex animal-origin matrices like meat and offal using the SCIEX QTRAP 7500 system.
- Explore their proficiency testing, method validation results, and ask questions directly from leading experts in the field.
From sample collection to data processing - PFAS program at State Hygienic Lab
Majid Nada Environmental Lab Scientist, State Hygienic Laboratory at the University of Iowa
Thursday, September 26
12:40 pm EDT
The State Hygienic Lab at University of Iowa had the PFAS program running for couple of years and is accredited and certified by the state, EPA, and UCMR5 program to test for PFAS in water samples. However, testing encompasses different environmental and biological matrices. This presentation will look at the program and focus on:
- Approaches from sample collection to data processing and reporting.
- Testing for PFAS in water matrices (drinking, raw, well, surface, and groundwater) based on EPA 537.1 and 533 PFAS methods.
- New method for PFAS in biological samples.
Q&A roundtables
Each day will conclude with a Q&A roundtable featuring our experts. Join the live discussion and engage with our panelists as they explore the latest technological advancements that are transforming quantitative research.
Day one: innovation and data insights
Moderated by: Jamie Wighton, Senior Director LC-MS Research, SCIEX
Panelists include:
- Rathna Veeramachaneni, Director, Biopharma LC-MS/MS, KCAS Bio
- Xiaping He, Senior Scientist, Pfizer
- Markus Stöckli, Senior Principal Scientist, Novartis Institutes for BioMedical Research
- Tony Purcell, Professor, Monash University
- Kevin Bateman, Retired Pharmacokinetics, Pharmacodynamics and Drug Metabolism Expert
A deeper look at high-resolution mass spectrometry
Moderated by: Jose Castro-Perez, Vice President of Product Management, SCIEX
Panelists include:
- Tom Lin, Instructor, Washington University in St. Louis
- Michael Witting, Deputy Head Metabolomics and Proteomics Core and Executive Manager Metabolomics, Helmholtz Munich
- Francisco José Díaz-Galiano, Postdoctoral researcher, University of Almería
- Kirsten Nields, Principal Scientist, J&J Innovative Medicines
- Tatjana Talamantes, Senior Product Manager, Accurate Mass, SCIEX
Day three: quantitation and screening
Moderated by: Ian Moore, Sr. Technical Product Manager, Nominal Mass, SCIEX
Panelists include:
- Roberto Riccio, Biochemie Lab
- Shane Karnik, Senior Laboratory Director, Aliri Bioanalysis
- Ebru Selen, Biologics Applications Scientist, SCIEX
- Paul Baker, Senior Scientific Liason, Lipidomics and Metabolomics, SCIEX
- Craig Butt, Senior Manager, Scientific Marketing, Applied Markets, SCIEX
Register today!
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